Abstract
A 17-year-old Caucasian female was admitted for a minor surgical procedure under general anesthesia. Fifteen minutes into the procedure, the patient experienced an acute hypermetabolic episode manifested by hyperthermia (41.6°C), tachycardia (heart rate 250), and increasing end-tidal carbon dioxide (ETCO2 65 mmHg). The procedure was terminated. A provisional diagnosis of malignant hyperthermia (MH) was made, and the patient was treated with a loading bolus of 2.5 mg/kg intravenous dantrolene, an antidote to MH-triggering agents. Subsequent bolus doses of 1 mg/kg were administered intravenously until the signs of acute MH abated and the ETCO2 normalized. The patient had an unconfirmed family history of a similar episode in a maternal uncle.
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© 2011 Springer-Verlag Berlin Heidelberg
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Pillai, R.K., Kant, J.A. (2011). Malignant Hyperthermia. In: Schrijver, I. (eds) Diagnostic Molecular Pathology in Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19677-5_8
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DOI: https://doi.org/10.1007/978-3-642-19677-5_8
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