Abstract
A male in his 50s with a history of prostate cancer presented for follow-up one year after prostatectomy. The follow-up computed tomography (CT) scan of the abdomen revealed a left renal solid enhancing mass. Under the clinical diagnosis of a renal neoplasm suspicious for malignancy, a left robotic-assisted partial nephrectomy was performed. Grossly, the tumor was confined to the kidney, measured 4.0 cm in greatest dimension and showed a homogenously tan-yellow cut surface with friable tissue and necrosis. Microscopically, the tumor demonstrated cells arranged in closely packed tubules and focal papillary architecture (Fig. 25.1a). Tumor cells displayed uniform, round to oval nuclei (Fuhrman nuclear grade 2) and had scant eosinophilic cytoplasm. Foamy macrophages and scant extracellular mucin were noted (Fig. 25.1b). No lymphovascular invasion was identified.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Argani P, Netto G, Parwani AV (2008) Papillary renal cell carcinoma with low-grade spindle cell foci: a mimic of mucinous tubular and spindle cell carcinoma. Am J Surg Pathol 32:1353–1359
Shen SS, Ro JY, Tamboli P et al (2007) Mucinous tubular and spindle cell carcinoma of kidney is probably a variant of papillary renal cell carcinoma with spindle cell features. Ann Diagn Pathol 11:13–21
Kim HJ, Shen SS, Ayala AG et al (2009) Virtual-karyotyping with SNP microarrays in morphologically challenging renal cell neoplasms: a practical and useful diagnostic modality. Am J Surg Pathol 33:1276–1286
Brunelli M, Eble JN, Zhang S et al (2005) Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma. Mod Pathol 18:161–169
Monzon FA, Hagenkord J, Lyons-Weiler M et al (2008) Whole genome SNP arrays as a potential diagnostic tool for the detection of characteristic chromosomal aberrations in renal epithelial tumors. Mod Pathol 21:1–10
Wilhelm M, Veltman JA, Olshen AB et al (2002) Array-based comparative genomic hybridization for the differential diagnosis of renal cell cancer. Cancer Res 62:957–960
Beroukhim R, Lin M, Park Y et al (2006) Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays. PLoS Comput Biol 2:e41
Mc Sherry E, Mc Goldrick A, Kay E et al (2007) Formalin-fixed paraffin-embedded clinical tissues show spurious copy number changes in array-CGH profiles. Clin Genet 72:441–447
Alvarez K, Kash SF, Lyons-Weiler MA et al (2010) Reproducibility and performance of virtual karyotyping with SNP microarrays for the detection of chromosomal imbalances in formalin-fixed paraffin embedded tissues. Diagn Mol Patho 19:127–134
Hagenkord JM, Parwani AV, Lyons-Weiler MA et al (2008) Virtual karyotyping with SNP microarrays reduces uncertainty in the diagnosis of renal epithelial tumors. Diagn Pathol 3:44
Yamamoto G, Nannya Y, Kato M et al (2007) Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays. Am J Hum Genet 81:114–126
Alvarez K, Kash SF, Lyons-Weiler MA et al (2010) Reproducibility and performance of virtual karyotyping with SNP microarrays for the detection of chromosomal imbalances in formalin-fixed paraffin-embedded tissues. Diagn Mol Pathol 19:127–134
Eble JN, World Health Organization, International Agency for Research on Cancer, International Academy of Pathology (2004) Pathology and genetics of tumours of the urinary system and male genital organs. IARC Press; Oxford University Press (distributor), Lyon; Oxford
Zisman A, Chao DH, Pantuck AJ et al (2002) Unclassified renal cell carcinoma: clinical features and prognostic impact of a new histological subtype. J Urol 168:950–955
Szponar A, Zubakov D, Pawlak J et al (2009) Three genetic developmental stages of papillary renal cell tumors: duplication of chromosome 1q marks fatal progression. Int J Cancer 124:2071–2076
Brunelli M, Gobbo S, Cossu-Rocca P et al (2007) Chromosomal gains in the sarcomatoid transformation of chromophobe renal cell carcinoma. Mod Pathol 20:303–309
Jones TD, Eble JN, Wang M et al (2005) Clonal divergence and genetic heterogeneity in clear cell renal cell carcinomas with sarcomatoid transformation. Cancer 104:1195–1203
Coleman JA, Russo P (2009) Hereditary and familial kidney cancer. Curr Opin Urol 19:478–485
van den Berg E, Storkelvan S (2003) Kidney: Renal Cell Carcinoma. http://AtlasGeneticsOncology.org/Tumors/RenalCellCarcinID5021.html. Published 06-2003
Lam JS, Shvarts O, Leppert JT et al (2005) Renal cell carcinoma 2005: new frontiers in staging, prognostication and targeted molecular therapy. J Urol 173:1853–1862
Yin D, Ogawa S, Kawamata N et al (2009) High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray. Mol Cancer Res 7:665–677
Argani P, Ladanyi M (2005) Translocation carcinomas of the kidney. Clin Lab Med 25:363–378
Alimov A, Sundelin B, Wang N et al (2004) Loss of 14q31-q32. 2 in renal cell carcinoma is associated with high malignancy grade and poor survival. Int J Oncol 25:179–185
Klatte T, Rao PN, de Martino M et al (2009) Cytogenetic profile predicts prognosis of patients with clear cell renal cell carcinoma. J Clin Oncol 27:746–753
Brunelli M, Eccher A, Gobbo S et al (2008) Loss of chromosome 9p is an independent prognostic factor in patients with clear cell renal cell carcinoma. Mod Pathol 21:1–6
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Monzon, F.A. (2011). Renal Cell Carcinoma. In: Schrijver, I. (eds) Diagnostic Molecular Pathology in Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19677-5_25
Download citation
DOI: https://doi.org/10.1007/978-3-642-19677-5_25
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-19676-8
Online ISBN: 978-3-642-19677-5
eBook Packages: MedicineMedicine (R0)