The signal: statistical aspects, normalisation, elementary analysis

  • Samuel Wieczorek


The elementary analysis of raw data coming from automated pharmacological screening (i.e. the bioactivity signals) aims to identify bioactive molecules (called candidate hits) that will then be subjected to more in-depth testing. This selection is made by setting a bioactivity threshold and the interesting molecules are therefore identified purely on the basis of the bioactivity signal. This measure represents the most concise information about the bioactivity of compounds in a chemical library and is as such particularly precious.


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© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Samuel Wieczorek
    • 1
  1. 1.Laboratory of Large-Scale BiologyInstitute of Life Sciences Research and Technologies, CEAGrenobleFrance

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