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Abstract

The word ‘embolus’ comes from the Greek ‘embolos’ meaning a wedge or plug. ‘Embolos’ was derived from ‘en’ (in) + ‘ballein’ (to throw), so an embolus is something thrown in. A 1913 medical definition of an embolus was: ‘A plug of some substance lodged in a blood vessel, being brought to thither by the blood current. It consists most frequently of a clot of fibrin, a detached shred of a morbid growth, a globule of fat or a microscopic organism.’ To this definition we must now add a material either as a therapeutic agent or inadvertently.

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References

  1. Picard L, Even J, Bertrand A, Floquet J, Yvroud E, Folcher J, Sigiel M, Marchal AL, L’Espérance G, Roland J. Fluid plastic embols. Experimental study. J Neuroradiol. 1977;4(4):385–98.

    PubMed  CAS  Google Scholar 

  2. Standard SC, Standard SC, Guterman LR, Chavis TD, Hopkins LN. Delayed recanalization of a cerebral arteriovenous malformation following angiographic obliteration with polyvinyl alcohol embolisation. Surg Neurol. 1995;44(2):109–12; discussion 112–3.

    Article  PubMed  CAS  Google Scholar 

  3. Barth KH, Strandberg JD, White Jr RI. Long term follow-up of transcatheter embolization with autologous clot, oxycel and gelfoam in domestic swine. Invest Radiol. 1977;12(3):273–80.

    Article  PubMed  CAS  Google Scholar 

  4. Speakman TJ. Internal occlusion of a carotid-cavernous fistula. J Neurosurg. 1964;21:303–5.

    Article  PubMed  CAS  Google Scholar 

  5. Berenstein A, Russell E. Gelatin sponge in therapeutic neuroradiology: a subject review. Radiology. 1981;141(1):105–12.

    PubMed  CAS  Google Scholar 

  6. Tomizawa Y. Clinical benefits and risk analysis of topical hemostats: a review. J Artif Organs. 2005;8(3):137–42.

    Article  PubMed  Google Scholar 

  7. Struk D, Rankin RN, Karlik SJ. Stability studies on chemoembolization mixtures. Dialysis studies of doxorubicin and lipiodol with Avitene, Gelfoam, and Angiostat. Invest Radiol. 1993;28(11):1024–7.

    Article  PubMed  CAS  Google Scholar 

  8. Valentine R, Wormald PJ, Sindwani R. Advances in absorbable biomaterials and nasal packing. Otolaryngol Clin North Am. 2009;42(5):813–28, ix.

    Article  PubMed  Google Scholar 

  9. Hilal SK, Michelsen JW. Therapeutic percutaneous embolization for extra-axial vascular lesions of the head, neck, and spine. J Neurosurg. 1975;43:275–87.

    Article  PubMed  CAS  Google Scholar 

  10. Barr JD, Lemley TJ, Petrochko CN. Polyvinyl alcohol foam particle sizes and concentrations injectable through microcatheters. J Vasc Interv Radiol. 1998;9(1 Pt 1):113–8.

    Article  PubMed  CAS  Google Scholar 

  11. Jack Jr CR, Forbes G, Dewanjee MK, Brown ML, Earnest 4th F. Polyvinyl alcohol sponge for embolotherapy: particle size and morphology. AJNR Am J Neuroradiol. 1985;6(4):595–7.

    PubMed  Google Scholar 

  12. Lylyk P, Vinuela F, Vinters HV, Dion J, Bentson J, Duckwiler G, Lin T. Use of a new mixture for embolization of intracranial vascular malformations. Preliminary experimental experience. Neuroradiology. 1990;32(4):304–10.

    Article  PubMed  CAS  Google Scholar 

  13. Beaujeux R, Lauren A, Wassef M, Casasco A, Gobin YP, Aymard A, Rüfenacht D, Merland JJ. Trisacryl gelatin microspheres for therapeutic embolization, II: preliminary clinical evaluation in tumors and arteriovenous malformations. AJNR Am J Neuroradiol. 1996;17(3):541–8.

    PubMed  CAS  Google Scholar 

  14. HepaSphere/Quadrasphere microspheres for delivery of doxorubicin for the treatment of hepatocellular cancer (HiQuality). http://clinicaltrials.gov/ct2/show/NCT01387932.

  15. Guglielmi G, Viñuela F, Dion J, Duckwiler G. Electrothrombosis of saccular aneurysms via endovascular approach. Part 2: preliminary clinical experience. J Neurosurg. 1991;75(1):8–14.

    Article  PubMed  CAS  Google Scholar 

  16. Ducros V, Weill A, Cognard C, Piotin M, Moret J. To the editor. Corrosion of tungsten spirals. Interv Neuroradiol. 1999;5(1):81–2. Epub 15 May 2001.

    PubMed  CAS  Google Scholar 

  17. Murayama Y, Vinuela F, Tateshima S, et al. Cellular response of bioabsorbable polymeric material and Guglielmi detachable coil in experimental aneurysms. Stroke. 2002;33:1120–8.

    Article  PubMed  Google Scholar 

  18. Ming-hua L, Wen-bin Li W, Chun Fang C, Gao B. Transarterial embolization with berenstein liquid coils and N-butyl cyanoacrylate in a vein of Galen aneurysmal malformation: a case report. Korean J Radiol. 2007;8(2):164–8.

    Article  Google Scholar 

  19. Serbinenko FA. Balloon catheterization and occlusion of major cerebral vessels. J Neurosurg. 1974;41:125–8.

    Article  PubMed  CAS  Google Scholar 

  20. Taki W, Handa H, Miyake H, Kobayashi A, Yonekawa Y, Yamamura K, Suzuki M, Ikada Y. New detachable balloon technique for traumatic carotid-cavernous sinus fistulae. AJNR Am J Neuroradiol. 1985;6:961–4.

    PubMed  CAS  Google Scholar 

  21. Dion JE, VinueIa F, Halbach VV, Dion JE, editors. Principle and methodology. Interventional neuroradiology. Endovascular therapy of the central nervous system. New York: Raven Press; 1992.

    Google Scholar 

  22. Samson D, Marshall D. Carcinogenic potential of isobutyl-2-cyanoacrylate. J Neurosurg. 1986;65(4):571–2.

    PubMed  CAS  Google Scholar 

  23. Spiegel SM, Viñuela F, Goldwasser JM, Fox AJ, Pelz DM. Adjusting the polymerization time of isobutyl-2 cyanoacrylate. AJNR Am J Neuroradiol. 1986;7(1):109–12.

    PubMed  CAS  Google Scholar 

  24. Debrun GM, Aletich V, Ausman JI, Charbel F, Dujovny M. Embolization of the nidus of brain arteriovenous malformations with n-butyl cyanoacrylate. Neurosurgery. 1997;40(1):112–20.

    PubMed  CAS  Google Scholar 

  25. Debrun GM, Aletich VA, Shownkeen H, Ausman J. Glued catheters during embolisation of brain AVMs with acrylic glue. Interv Neuroradiol. 1997;3(1):13–9. Epub 15 May 2001.

    PubMed  CAS  Google Scholar 

  26. Kerber CW, Cromwell LD, Zanetti PH. Experimental carotid aneurysms: part 2. Endovascular treatment with cyanoacrylate. Neurosurgery. 1985;16(1):13–7.

    Article  PubMed  CAS  Google Scholar 

  27. Zanetti PH, Sherman FE. Experimental evaluation of a tissue adhesive as an agent for the treatment of aneurysms and arteriovenous anomalies. J Neurosurg. 1972;36(1):72–9.

    Article  PubMed  CAS  Google Scholar 

  28. Komotar RJ, Ransom ER, Wilson DA, Connolly Jr ES, Lavine SD, Meyers PM. 2-Hexyl cyanoacrylate (neuracryl M) embolization of cerebral arteriovenous malformations. Neurosurgery. 2006;59(4 Suppl 2):ONS464–9.

    PubMed  Google Scholar 

  29. Barr JD, Hoffman EJ, Davis BR, Edgar KA, Jacobs CR. Microcatheter adhesion of cyanoacrylates: comparison of normal butyl cyanoacrylate to 2-hexyl cyanoacrylate. J Vasc Interv Radiol. 1999;10(2 Pt 1):165–8.

    Article  PubMed  CAS  Google Scholar 

  30. Taki W, Yonekawa Y, Iwata H, Uno A, Yamashita K, Amemiya H. A new liquid material for embolization of arteriovenous malformations. AJNR Am J Neuroradiol. 1990;11:163–8.

    PubMed  CAS  Google Scholar 

  31. van Rooi WJ, Sluzewski M, Beute GN. Brain AVM embolization with onyx. AJNR Am J Neuroradiol. 2007;28:172–7.

    Google Scholar 

  32. Higgins JNP, Byrne JV, Krulle TM, Fleet GWJ. Capping the coil. Neuroradiology. 1996;39:146.

    Google Scholar 

  33. Orford J, Barker A, Thonell S, King P, Murphy J. Bleomycin therapy for cystic hygroma. J Pediatr Surg. 1995;30(9):1282–7.

    Article  PubMed  CAS  Google Scholar 

  34. Study of picibanil (OK432) sclerotherapy in children with macrocystic lymphatic malformations. clinicaltrials.gov/ct2/show/NCT00010452.

  35. Grzyska U, Westphal M, Zanella F, Freckmann N, Herrmann HD, Zeumer H. A joint protocol for the neurosurgical and neuroradiological treatment of cerebral arteriovenous malformations: indications, technique, and results in 76 cases. Surg Neurol. 1993;40(6):476–84.

    Article  PubMed  CAS  Google Scholar 

  36. Dotter CT, Transluminally - placed coilspring endarterial tube grafts long-term patency in canine popliteal artery. Invest Radio. 1969;4:329–32.

    Article  PubMed  Google Scholar 

  37. Liou TM, Li YC. Juan WC Numerical and experimental studies on pulsatile flow in aneurysms arising laterally from a curved parent vessel at various angles. J Biomech. 2007;40(6):1268–75.

    Article  PubMed  Google Scholar 

  38. Byrne JV, Beltechi R, Yarnold JA, Birks J, Kamran M. Early experience in the treatment of intra-cranial aneurysms by endovascular flow diversion: a multicentre prospective study. PLoS One. 2010;5(9):pii: e12492.

    Article  Google Scholar 

  39. Doerfler A, Wanke I, Egelhof T, Stolke D, Forsting M. Double-stent method: therapeutic alternative for small wide-necked aneurysms. Technical note. J Neurosurg. 2004;100(1):150–4.

    Article  PubMed  Google Scholar 

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Correspondence to James Vincent Byrne .

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Byrne, J.V. (2012). Embolic Agents. In: Tutorials in Endovascular Neurosurgery and Interventional Neuroradiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19154-1_18

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  • DOI: https://doi.org/10.1007/978-3-642-19154-1_18

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