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The Spindle Assembly Checkpoint: Clock or Domino?

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Cell Cycle in Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS))

Abstract

In each cell division, the newly duplicated chromosomes must be evenly distributed between the sister cells. Errors in this process during meiosis or mitosis are equally fatal: improper segregation of the chromosome 21 during human meiosis leads to Down syndrome (Conley, Aneuploidy: etiology and mechanisms, pp 35–89, 1985), whereas in somatic cells, aneuploidy has been linked to carcinogenesis, by unbalancing the ratio of oncogenes and tumor suppressors (Holland and Cleveland, Nat Rev Mol Cell Biol 10(7):478–487, 2009; Yuen et al., Curr Opin Cell Biol 17(6):576–582, 2005). Eukaryotic cells have developed a mechanism, known as the spindle assembly checkpoint, to detect erroneous attachment of chromosomes to the mitotic/meiotic spindle and delay the cell cycle to give enough time to resolve these defects. Research in the last 20 years, has demonstrated that the spindle assembly checkpoint is not only a pure checkpoint pathway, but plays a constitutive role in every cell cycle. Here, we review our current knowledge of how the spindle assembly checkpoint is integrated into the cell cycle machinery, and discuss some of the questions that have to be addressed in the future.

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Acknowledgments

We would like to thank all the Meraldi laboratory members for the helpful discussions. MDMR is supported by an Oncosuisse grant, PM is supported by a Förderungs-professorship or the Swiss National Research Fund, a EURYI-award by the European Research Council and the ETH Zurich.

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  1. Institute of Biochemistry, ETH Zurich, 8093, Zurich, Switzerland

    María de Medina-Redondo & Patrick Meraldi

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  1. María de Medina-Redondo
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Correspondence to María de Medina-Redondo or Patrick Meraldi .

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  1. CNRS UMR 6061, Fac. Médecine, Université de Rennes 1, Rennes CX, 35043, France

    Jacek Z. Kubiak

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de Medina-Redondo, M., Meraldi, P. (2011). The Spindle Assembly Checkpoint: Clock or Domino?. In: Kubiak, J. (eds) Cell Cycle in Development. Results and Problems in Cell Differentiation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19065-0_4

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