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Tacrolimus hemmt die dermale, nicht jedoch die intestinale Wundheilung

Tacrolimus impairs dermal but not intestinal wound healing

  • Conference paper
Chirurgisches Forum 2003 für experimentelle und klinische Forschung

Part of the book series: Deutsche Gesellschaft für Chirurgie ((FORUMBAND,volume 32))

  • 41 Accesses

Abstract

Tacrolimus, used in solid organ transplantation, inhibits T-cell activation. Little is known about its effect on the immunoregulation of dermal and intestinal healing. In rats, the effect of tacrolimus (1–5 mg/kg/d) on dermal and left colonic healing was tested 10 days and 5 days post-wounding, respectively. Tacrolimus impaired dermal but not intestinal healing. Impaired healing was reflected in decreased levels of TGF-β (stimulates healing) and increased levels of IFN-γ and TNF-α (both impair healing) in wound fluid.

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Literatur

  1. Thomson AW, Bonham CA, Zeevi A (1995) Mode of action of tacrolimus (FK506): Molecular and cellular mechanisms. Therap Orug Monit 17: 584–589

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Authors and Affiliations

  1. Chirurgische Universitätsklinik am Knappschaftskrankenhaus Bochum-Langendreer, Deutschland

    Priv.-Doz. Dr. Michael Schäffer, N. Fuchs, J. Völker & R. Viebahn

Authors
  1. Priv.-Doz. Dr. Michael Schäffer
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  2. N. Fuchs
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  3. J. Völker
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  4. R. Viebahn
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Corresponding author

Correspondence to Michael Schäffer .

Editor information

Editors and Affiliations

  1. Universität des Saarlandes, 66421, Homburg/Saar, Deutschland

    M. D. Menger (Direktor der Abteilung für Klinisch-Experimentelle Chirurgie) (Direktor der Abteilung für Klinisch-Experimentelle Chirurgie)

  2. Universitätsklinikum Charité Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Deutschland

    N. P. Haas (Direktor der Klinik für Unfall- und Wiederherstellungschirurgie) (Direktor der Klinik für Unfall- und Wiederherstellungschirurgie)

  3. II. Chirurgischer Lehrstuhl, Universität zu Köln, Ostmerheimer Straße 58/59, 51109, Köln, Deutschland

    E. Neugebauer (Leiter der Biochemischen und Experimentellen Abteilung) (Leiter der Biochemischen und Experimentellen Abteilung)

  4. Deutsche Gesellschaft für Chirurgie Geschäftsstelle, Luisenstraße 58/59, 10117, Berlin, Deutschland

    H. Bauer

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© 2003 Springer-Verlag Berlin Heidelberg

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Schäffer, M., Fuchs, N., Völker, J., Viebahn, R. (2003). Tacrolimus hemmt die dermale, nicht jedoch die intestinale Wundheilung. In: Menger, M.D., Haas, N.P., Neugebauer, E., Bauer, H. (eds) Chirurgisches Forum 2003 für experimentelle und klinische Forschung. Deutsche Gesellschaft für Chirurgie, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19024-7_63

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  • DOI: https://doi.org/10.1007/978-3-642-19024-7_63

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-00659-6

  • Online ISBN: 978-3-642-19024-7

  • eBook Packages: Springer Book Archive

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