Abstract
Suramin, a polysulfonated naphthylurea compound, inhibits the proliferation of several human tumors in vitro and in vivo. The mechanisms of Suramin action include the inhibition of growth factor binding, an antiangiogenic effect and the inhibition of various nuclear enzymes. This study evaluates the effect of Suramin on proliferation, viability, cell cycle and apoptosis of human pancreatic cancer cells in vitro and in vivo growth in a clinically relevant orthotopic nude mouse model of pancreatic cancer. Cell cycle analysis revealed a decreased S-phase and an increased G0/G1-phase after Suramin treatment in 4 cell lines (Capan-2, PANC-1, MIAPaCa-2, AsPC-1), whereas the percentage of Capan-1-cells in S-phase was increased. High concentrations of Suramin increased the apoptotic fraction in all 5 cell lines, Suramin inhibited the proliferation of pancreatic cancer cells in a dose-dependent manner and reduced viability at high concentrations. The mechanisms of in vitro action of this antiproliferative drug seem to involve alterations of cell cycle kinetics and apoptosis. In vivo treatment with Suramin significantly reduced pancreatic tumor size and metastatic spread in an orthotopic nude mouse model.
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Literatur
Liberman SM, Horig H, Kaufman HL (2001) Innovative treatments for pancreatic cancer. Surg Clin North Am 81: 715–739
Heicappell R (2002) Controversies in chemotherapy of prostate cancer. Front Radiat Ther Oncol 36: 72–80
Arlt W, Reincke M, Siekmann L, Winkelmann W, Allolio B (1994) Suramin in adrenocortical cancer: limited efficacy and serious toxicity. Clin Endocrinol (Oxf) 41: 299–307
Gilch S, Winklhofer KF, Groschup MH, Nunziante M, Lucassen R, Spielhaupter C, Muranyi W, Riesner D, Tatzelt J, Schatzl HM (2001) Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease. EMBO J 20: 3957–3966
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Porebski, A., Hotz, H.G., Hotz, B., Buhr, H.J. (2003). Suramin hemmt das Wachstum des humanen Pankreaskarzinoms in vitro und in vivo. In: Menger, M.D., Haas, N.P., Neugebauer, E., Bauer, H. (eds) Chirurgisches Forum 2003 für experimentelle und klinische Forschung. Deutsche Gesellschaft für Chirurgie, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19024-7_43
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DOI: https://doi.org/10.1007/978-3-642-19024-7_43
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-00659-6
Online ISBN: 978-3-642-19024-7
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