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Multiple Mechanisms of Transcriptional Repression in Eukaryotes

  • Chapter
Transcription Factors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 166))

Abstract

The selective transcription of eukaryotic genes is regulated by both positive and negative inputs from sequence-specific DNA-binding factors. These proteins provide the information essential for correct temporal and spatial control of transcription. The activities of transcriptional repressors have been characterized by a variety of methods, but in many cases the physiological relevance of proposed mechanisms has not been established. This chapter reviews pathways of repression, critically evaluates criteria by which repression mechanisms can be analyzed, and discusses recent progress in identifying the functional relevance of multiple repression activities of transcriptional repressors.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, 48824-1319, USA

    D. N. Arnosti

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  1. D. N. Arnosti
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Editors and Affiliations

  1. Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Strasse 10, 13125, Berlin, Germany

    Manfred Gossen

  2. atugen AG, Robert-Rössle-Strasse 10, 13125, Berlin, Germany

    Jörg Kaufmann

  3. Department of Biochemistry and Molecular Biology, Michigan State University, 510 Biochemistry Building, East Lansing, MI, 48824-1319, USA

    Steven J. Triezenberg (Associate Director) (Associate Director)

  4. Graduate Program in Cell and Molecular Biology, Michigan State University, 510 Biochemistry Building, East Lansing, MI, 48824-1319, USA

    Steven J. Triezenberg (Associate Director) (Associate Director)

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© 2004 Springer-Verlag

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Arnosti, D.N. (2004). Multiple Mechanisms of Transcriptional Repression in Eukaryotes. In: Gossen, M., Kaufmann, J., Triezenberg, S.J. (eds) Transcription Factors. Handbook of Experimental Pharmacology, vol 166. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18932-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-18932-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62361-5

  • Online ISBN: 978-3-642-18932-6

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