Abstract
We have learned much about the cellular and molecular biology of regeneration, but are far from knowing enough to translate it into a regenerative medicine. The proliferation kinetics, surface antigen phenotypes, and array of transcription factors for several types of adult stem cells have been partially characterized, enabling their enrichment by FACS after harvest, but the molecular phenotype of other adult stem cells remains uncharacterized. A significant area of research is the identification of the soluble and insoluble signals and their transduction pathways that govern the proliferation and differentiation of regeneration-competent cells. In the case of some cells, such as HSCs, many of these signals are known, but in most cases our information is incomplete.
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© 2004 Springer-Verlag Berlin Heidelberg
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Stocum, D.L. (2004). Perspectives. In: Tissue Restoration Through Regenerative Biology and Medicine. Advances in Anatomy Embryology and Cell Biology, vol 176. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18928-9_3
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DOI: https://doi.org/10.1007/978-3-642-18928-9_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20603-3
Online ISBN: 978-3-642-18928-9
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