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Role of Tachykinins in Obstructive Airway Disease

  • Chapter
Tachykinins

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 164))

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Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are characterized by airway obstruction, hyperresponsiveness and inflammation. The tachykinins substance P and neurokinin A are present in the human airways where they are found in sensory nerves and immune cells. Tachykinins are released in the airways after inhalation of ozone, cigarette smoke or allergen. They interact in the airways with tachykinin NK1, NK2 and NK3 receptors to cause bronchoconstriction, plasma protein extravasation, and mucus secretion and to attract and activate immune cells. In preclinical studies they have been implicated in the pathophysiology of asthma and COPD, including allergen-and cigarette smoke-induced airway inflammation and bronchial hyperresponsiveness. So, tachykinin receptor antagonists have potential in the treatment of asthma and COPD. With the arrival of more potent dual and triple tachykinin receptor antagonists the tools to obtain a more definite judgment about the role of tachykinins in airway diseases such as asthma and COPD are now available.

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References

  • Adcock IM, Peters M, Gelder C, Shirasaki H, Brown CR, Barnes PJ (1993) Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids. J Mol Endocrinol 11: 1–7

    Article  PubMed  CAS  Google Scholar 

  • Advenier C, Ioos G, Molimard M, Lagente V, Pauwels R (1999) Role of tachykinins as contractile agonists of human airways in asthma. Clin Exp Allergy 29: 579-584

    Google Scholar 

  • Advenier C, Lagente V, Boichot E (1997) The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough. Eur Respir J 10: 1892–906

    Article  PubMed  CAS  Google Scholar 

  • Advenier C, Naline E, Drapeau G, Regoli D (1987) Relative potencies of neurokinins in guinea-pig trachea and human bronchus. Eur J Pharmacoll 39: 133–137

    Article  Google Scholar 

  • Advenier C, Naline E, Toty L, Bakdach H, Edmonds-Alt X, Vilain P, Breliere J-C, Le Fur G (1992) Effects on the isolated human bronchus of SR 48968, a potent and selective non peptide antagonist of the neurokinin A (NK1) receptors. Am Rev Respir Dis 146: 1177–1181

    PubMed  CAS  Google Scholar 

  • Amadesi S, Moreau J, Tognetto M, Springer J, Trevisani M, Naline E, Advenier C, Fischer A, Vinci D, Mapp CE, Miotto D, Geppetti P (2001) NK1 receptor stimulation causes contraction and inositol phosphate increase in medium-size human isolated bronchi. Am J Respir Crit Care Med 163: 1206–1211

    PubMed  CAS  Google Scholar 

  • Anthes JC, Chapman RW, Richard C, Eckel S, Corboz M, Hey JA, Fernandez X, Greenfeder S, McLeod R, Sehring S, Rizzo C, Crawley Y, Shih NY, Piwinski J, Reichard G, Ting P, Carruthers N, Cuss FM, Billah M, Kreutner W, Egan RW (2002) SCH 206272: a potent, orally active tachykinin NK1, NK1 and NK3 receptor antagonist. Eur J Pharmacol 450: 191–202

    Article  PubMed  CAS  Google Scholar 

  • Bai TR, Zhou D, Weir T, Walker B, Hegele R, Hayashi S, McKay K, Bondy GP, Fong T (1995) Substance P (NK1-and neurokinin A (NK1)-receptor gene expression in inflammatory airway disease. Am J Physiol 269: L309–1317

    PubMed  CAS  Google Scholar 

  • Baraniuk IN, Ali M, Yuta A, Fang SY, Naranch K (1999) Hypertonic saline nasal provocation stimulates nociceptive nerves, substance P release, and glandular mucous exocytosis in normal humans. Am J Respir Crit. Care Med 160: 655–662

    PubMed  CAS  Google Scholar 

  • Barnes PJ (1986) Asthma as an axon reflex. Lancet 1: 242–244

    Article  PubMed  CAS  Google Scholar 

  • Bertrand C, Geppetti P, Baker J, Yamawaki I, Nadel JA (1993a) Role of neurogenic inflammation in antigen-induced vascular extravasation in guinea pig trachea. J Immunol 150: 1479–1485

    PubMed  CAS  Google Scholar 

  • Bertrand C, Geppetti P, Baker J, Yamawaki I, Nadel JA (1993b) Tachykinins, via NK1 receptor activation, playa relevant role in plasma protein extravasation evoked by allergen challenge in the airways of sensitized guinea-pigs. Regul Pept 46: 214–216

    Article  PubMed  CAS  Google Scholar 

  • Bertrand C, Geppetti P, Graf PD, Foresi A, Nadel JA (1993c) Involvement of neurogenic inflammation in antigen-induced bronchoconstriction in guinea pigs. Am J Physiol 265: L507–L511

    PubMed  CAS  Google Scholar 

  • Bonini S, Lambiase A, Angelucci F, Magrini L, Manni L, Aloe L (1996) Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma. Proc Nat! Acad Sci USA 93: 10955–10960

    Article  PubMed  CAS  Google Scholar 

  • Bonini S, Lambiase A, Levi-Schaffer F, Aloe L (1999) Nerve growth factor: an important molecule in allergic inflammation and tissue remodelling. Int Arch Allergy Immunol 118: 159–162

    Article  PubMed  CAS  Google Scholar 

  • Bousquet J (2000) Global initiative for asthma (GINA) and its objectives. Clin Exp Allergy 30(Suppll): 2–5

    Article  PubMed  Google Scholar 

  • Bowden JJ, Garland AM, Baluk P, Lefevre P, Grady EF, Vigna SR, Bunnett NW, McDonald DM (1994) Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation. Proc Nat! Acad Sci USA 91: 8964–8968

    Article  PubMed  CAS  Google Scholar 

  • Braun A, Lommatzsch M, Renz H (2000) The role of neurotrophins in allergic bronchial asthma. Clin Exp. Allergy 30: 178–186

    Article  PubMed  CAS  Google Scholar 

  • Canning BJ, Reynolds SM, Anukwu LU, Kajekar R, Myers AC (2002) Endogenous neurokinins facilitate synaptic transmission in guinea pig airway parasympathetic ganglia. Am J Physiol 283: R320–R330

    CAS  Google Scholar 

  • Carr MJ, Hunter DD, Jacoby DB, Undem BJ (2002) Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigs. Am J Respir Crit Care Med 165: 1071–1075

    PubMed  Google Scholar 

  • Catalioto R-M, Criscuoli M, Cucchi P, Giachetti A, Giannotti D, Giuliani S, Lecci A, Lippi A, Patacchini R, Quartara L, Renzetti AR, Tramontana M, Arcamone F, Maggi CA (1998) MEN 11420 (Nepadutant), a novel glycosylated bicyclic peptide tachykinin NK2 receptor antagonist. Br J Pharmacol 123: 81–91

    Article  PubMed  CAS  Google Scholar 

  • Chanez P, Springall D, Vignola AM, Moradoghi-Hattvani A, Polak JM, Godard P, Bousquet J (1998) Bronchial mucosal immunoreactivity of sensory neuropeptides in severe airway diseases. Am J Respir Crit Care Med 158: 985–990

    PubMed  CAS  Google Scholar 

  • Chu HW, Kraft M, Krause JE, Rex MD, Martin RJ (2000) Substance P and its receptor neurokinin 1 expression in asthmatic airways. J Allergy Clin lmmunol 106: 713–722

    Article  CAS  Google Scholar 

  • Crimi N, Oliveri R, Polosa R, Palermo F, Mistretta A (1993) The effect of oral terfenadine on neurokinin-A induced bronchoconstriction. J Allergy Clin Immunol 91: 1096–1098

    Article  PubMed  CAS  Google Scholar 

  • Crimi N, Pagano C, Palermo F, Mastruzzo C, Prosperini G, Pistorio MP, Vancheri C (2003) Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin A-induced bronchoconstriction. J Allergy Clin. Immunol 111: 833–839

    Article  PubMed  CAS  Google Scholar 

  • Crimi N, Palermo F, Oliveri R, Palermo B, Vancheri C, Polosa R, Mistretta A (1988) Effect of nedocromil on bronchospasm induced by inhalation of substance P in asthmatic subjects. Clin Allergy 18: 375–382

    Article  PubMed  CAS  Google Scholar 

  • Crimi N, Palermo F, Oliveri R, Palermo B, Vancheri C, Polosa R, Mistretta A (1990) Influence of antihistamine (astemizole) and anticholinergic drugs (ipratropium bromide) on bronchoconstriction induced by substance P. Ann Allergy 65: 115–120

    PubMed  CAS  Google Scholar 

  • Daoui S, Cognon C, Naline E, Edrnonds-Alt X (1998) Involvement of tachykinin NK3 receptors in citric acid-induced cough and bronchial responses in guinea pigs. Am J Respir Crit Care Med 158: 42–48

    PubMed  CAS  Google Scholar 

  • Daoui S, Naline E, Lagente V, Emonds-Alt X, Advenier C (2000) Neurokinin B-and specific tachykinin NK3 receptor agonists-induced airway hyperresponsiveness in the guinea-pig. Br J Pharmacol 130: 49–56

    Article  PubMed  CAS  Google Scholar 

  • De Vries A, Dessing MC, Engels F, Henricks PAJ, Nijkamp FP (1999) Nerve growth factor induces a neurokinin-1 receptor-mediated airway hyperresponsiveness in guinea pigs. Am J Respir Crit Care Med 159: 1541–1544

    PubMed  Google Scholar 

  • Delaunois A, Gustin P, Ansay M (1993a) Effects of capsaicin on the endothelial permeability in isolated and perfused rabbit lungs. Fund Clin Pharmacol 7: 81–91

    Article  CAS  Google Scholar 

  • Delaunois A, Gustin P, Ansay M (1993b) Role of neuropeptides in acetylcholine-induced edema in isolated and perfused rabbit lungs. J Pharmacol Exp Ther 266: 483–491

    PubMed  CAS  Google Scholar 

  • Di Maria GU, Bellofiore S, Geppetti P (1998) Regulation of airway neurogenic inflammation by neutral endopeptidase. Eur Respir J 12: 1454–1462

    Article  PubMed  Google Scholar 

  • Diemunsch P, Grelot L (2000) Potential of substance P antagonists as antiemetics. Drugs 60: 533–546

    Article  PubMed  CAS  Google Scholar 

  • Emonds-Alt X, Vilain P, Goulaouic P, Proietto V, Van Broeck D, Advenier C, Naline E, Neliat G, Le Fur G, Breliere JC (1992) A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor. Life Sci 50: L101–L106

    Article  Google Scholar 

  • Fahy JV, Wong HH, Geppetti P, Reis JM, Harris SC, Maclean DB, Nadel JA, Boushey HA (1995) Effect of an NK1 receptor antagonist (CP-99,994) on hypertonic saline-induced bronchoconstriction and cough in male asthmatic subjects. Am J Respir Crit Care Med 152: 879–884

    PubMed  CAS  Google Scholar 

  • Fewtrell CMS, Foreman JC, Jordan CC, Oehma P, Renner H, Stewart JM (1982) The effects of substance P on histamine and 5-hydroxytryptamine release in the rat. J Physiol 330: 393–411

    PubMed  CAS  Google Scholar 

  • Finney MJB, Karlsson JA, Persson CGA (1985) Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. Br J Pharmacol 85: 29–36

    Article  PubMed  CAS  Google Scholar 

  • Fischer A, McGregor GP, Saria A, B Philippin, Kummer W (1996) Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation. J Clin Invest 98: 2284–2291

    Article  PubMed  CAS  Google Scholar 

  • Freund V, Pons F, Joly V, Mathieu E, Martinet N, Frossard N (2002) Upregulation of nerve growth factor expression by human airway smooth muscle cells in inflammatory conditions. Eur Respir J 20: 458–463

    Article  PubMed  CAS  Google Scholar 

  • Germonpre PR, Bullock GR, Lambrecht BN, Van De Velde V, Luyten WH, Joos GF, Pauwels RA (1999) Presence of substance P and neurokinin 1 receptors in human sputum macrophages and U-937 cells. Eur Respir J 14: 776–782

    Article  PubMed  CAS  Google Scholar 

  • Germonpre PR, Ioos GF, Everaert E, Kips JC, Pauwels RA (1995) Characterization of neurogenic inflammation in the airways of two highly inbred rat strains. Am.J.Respir.Crit. Care Med 152: 1796–1804

    PubMed  CAS  Google Scholar 

  • Germonpre PR, Ioos GF, Mekeirele K, Pauwels RA (1997) Role of the 5-HT receptor in neurogenic inflammation in Fisher 344 rat airways. Eur.l.Pharrnacol 324: 249–255

    Article  CAS  Google Scholar 

  • Graham RM, Friedman M, Hoyle GW (2001) Sensory nerves promote ozone-induced lung inflammation in mice. Am J Respir Crit Care Med 164: 307–313

    PubMed  CAS  Google Scholar 

  • Hansel TT, Erin EM, Barnes PJ (2002) The allergen challenge. Clin.Exp.Allergy 32: 162–167

    Article  PubMed  CAS  Google Scholar 

  • Hazbun ME, Hamilton R, Holian A, Eschenbacher WL (1993) Ozone-induced increases in substance P and 8-epi-prostaglandin F2a in the airways of human subjects. Am J Respir Cell Mol Biol 9: 568–572

    PubMed  CAS  Google Scholar 

  • Heaney LG, Cross LJM, McGarvey LPA, Buchanan KD, Ennis M, Shaw C (1998) Neurokinin A is the predominant tachykinin in human bronchoalveolar lavage fliud in normal and asthmatic subjects. Thorax 53: 357–362

    Article  PubMed  CAS  Google Scholar 

  • Hoglund C, de Blay F, Oster J-P, Duvernelle C, Kassel O, Pauli G, Frossard N (2002) Nerve growth factor levels and localisation in human asthmatic bronchi. Eur Respir J 20: 1110–1116

    Article  CAS  Google Scholar 

  • Howarth PH, Springall DR, Redington AE, Djukanovic R, Holgate S, Polak J (1995) Neuropeptide-containing nerves in endobronchial biopsies from asthmatic and nonasthmatic subjects. Am J Respir Cell Mol Biol 3: 288–296

    Google Scholar 

  • Hoyle GW, Graham RG, Finkelstein JB, Thi Nguyen K-P, Gozal D, Friedman M (1998) Hyperinnervation of the airways in transgenic mice overexpressing nerve growth factor. Am J Respir Cell Mol Biol 18: 149–157

    PubMed  CAS  Google Scholar 

  • Hu C, Wedde-Beer K, Auais A, Rodriguez MM, Piedimonte G (2002) Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs. Am J Physiol 283: L494–L502

    CAS  Google Scholar 

  • Hunter DD, Myers AC, Undem BJ (2000) Nerve Growth Factor-Induced Phenotypic Switch in Guinea Pig Airway Sensory Neurons. Am J Respir Crit. Care Med 161: 1985–1990

    PubMed  CAS  Google Scholar 

  • Ichinose M, Miura M, Yamauchi H, Kageyama N, Tomaki M, Oyake T, Ohuchi Y, Hida W, Miki H, Tamura G, Shirato K (1996) A neurokinin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients. Am J Respir Crit Care Med 153: 936–941

    PubMed  CAS  Google Scholar 

  • Ichinose M, Nakajima N, Takahashi T, Yamauchi H, Inoue H, Takishima T (1992) Protection against bradykinin-induced bronchoconstriction in asthmatic patients by neurokinin receptor antagonist. Lancet 340: 1248–1251

    Article  PubMed  CAS  Google Scholar 

  • Joos G, Schelfhout V, Van De Velde V, Pauwels R (2001) The effect of the tachykinin NKin2 receptor antagonist MENl1420 (nepadutant) on neurokinin A-induced bronchoconstriction in patients with asthma. Am J Respir Crit Care Med 163: A628

    Google Scholar 

  • Joos G, Van De Velde V, Schelfhout V, Pauwels R (2001) The leukotriene receptor antagonist zafirlukast inhibits neurokinin-A induced bronchoconstriction in patients with asthma. Am J Respir Crit Care Med 163: A418

    Google Scholar 

  • Joos GF and Pauwels RA (2001) Tachykinin receptor antagonists: potential in airways disease. Curr Opin Pharmacoll: 235–241

    Google Scholar 

  • Joos GF, Germonpre PR, Pauwels RA (2000) Role of tachykinins in asthma. Allergy 55: 321–337

    Article  PubMed  CAS  Google Scholar 

  • Joos GF, O’Connor B, Anderson SD, Chung F, Cockcroft DW, Dahlen B, DiMaria G, Foresi A, Hargreave FE, Holgate ST, Inman M, Lötvall, J., Magnussen, H., Polosa, R., Postma, D. S., and Riedler J (2003) Indirect airway challenges. Eur Respir 121: 1050–1068

    Article  Google Scholar 

  • Joos GF, Vincken W, Louis RE, Schelfhout VI, Shaw MJ, Wang J, Della Ciopa G, Pauwels RA (2004) The dual NK1/NK2 tachykinin receptor antagonist DNK 333 inhibits neurokinin A (NKA)-induced bronchoconstriction in patients with asthma. Eur Respir J 23: 76–81

    Article  PubMed  CAS  Google Scholar 

  • Joos G, Pauwels R, Van Der Straeten M (1989) The effect of nedocromil sodium on the bronchoconstrictor effect of neurokinin A in subjects with asthma. J Allergy Clin Immunol 83: 663–668

    Article  PubMed  CAS  Google Scholar 

  • Joos GF, De Swert KO, Pauwels RA (2001) Airway inflammation and tachykinins: prospects for the development of tachykinin receptor antagonists. Eur J Pharmacol 429: 239–250

    Article  PubMed  CAS  Google Scholar 

  • Joos GF, Germonpre PR, Kips JC, Peleman RA, Pauwels RA (1994) Sensory neuropeptides and the human lower airways: present state and future directions. Eur Respir J 7: 1161–1171

    PubMed  CAS  Google Scholar 

  • Joos GF, Germonpre PR, Pauwels RA (2000) Role of tachykinins in asthma. Allergy 55: 321–337

    Article  PubMed  CAS  Google Scholar 

  • Joos GF, Lefebvre RA, Bullock G, Pauwels RA (1997) Role of 5-hydroxytryptamine and mast cells in the tachykinin-induced contraction of rat trachea in vitro. Eur J Pharmacol 338: 259–268

    Article  PubMed  CAS  Google Scholar 

  • Joos GF, Pauwels RA (1993) The in vivo effect of tachykinins on airway mast cells in the rat. Am Rev Respir Dis 148: 922–926

    Article  PubMed  CAS  Google Scholar 

  • Joos GF, Pauwels RA (2000) Pro-inflammatory effects of substance P: new perspectives for the treatment of airway diseases? Trends Pharmacol Sci 21: 131–133

    Article  PubMed  CAS  Google Scholar 

  • Joos GF, Pauwels RA, Van Der Straeten ME (1988) The effect of oxitropiumbromide on neurokinin A-induced bronchoconstriction in asthmatics. Pulmon Pharmacology 1: 41–45

    Article  CAS  Google Scholar 

  • Joos GF, Van Schoor J, Kips JC, Pauwels RA (1996) The effect of inhaled FK244, a tachyki nin NK-1 and NK-2 receptor antagonist, on neurokinin A-induced bronchoconstriction in asthmatics. Am J Respir Crit Care Med 153: 1781–1784

    PubMed  CAS  Google Scholar 

  • Katsunuma T, Mak JCW, Barnes PJ (1998) Glucocorticoids reduce tachykinin NK2 receptor expression in bovine tracheal smooth muscle. Eur J Pharmacol 344: 99–106

    Article  PubMed  CAS  Google Scholar 

  • Khan S, Liu y-c, Khawaja AM, Manzini S, Rogers DF (2001) Effect of the long-acting tachykinin NK1 receptor antagonist MEN 11467 on tracheal mucus secretion in allergic ferrets. Br J Pharmacoll 32: 189–196

    Article  Google Scholar 

  • Kraan J, Vink-Klooster H, Postma DS (2001) The NK-2 receptor antagonist SR 48968C does not improve adenosine hyperresponsiveness and airway obstruction in allergic asthma. Clin Exp Allergy 31: 274–278

    Article  PubMed  CAS  Google Scholar 

  • Kraneveld AD, Nijkamp FP, Van Oosterhout AJM (1997) Role for neurokinin-2 receptor in interleukin-5-induced airway hyperresponsiveness but not eosinophilia in guinea pigs. Am J Respir Crit Care Med 156: 367–374

    PubMed  CAS  Google Scholar 

  • Krishna MT, Springall DR, Meng Q-H, Whiters N, Macleod D, Biscione G, Frew A, Polak J, Holgate S (1997) Effects of ozone on epithelium and sensory nerves in the bronchial mucosa of healthy humans. Am J Respir Crit Care Med 156: 943–950

    PubMed  CAS  Google Scholar 

  • Kudlacz EM, Knippenberg RW, Logan DE, Burkholder TP (1996) Effect of MDL 105,212, a nonpeptide NK-1/NK-2 receptor antagonist in an allergic guinea pig model. J Pharmacol Exp Ther 279: 732–739

    PubMed  CAS  Google Scholar 

  • Lamb JP, Sparrow MP (2002) Three-dimensional mapping of sensory innervation with substance p in porcine bronchial mucosa: comparison with human airways. Am. J Respir Crit Care Med 166: 1269–1281

    Article  PubMed  Google Scholar 

  • Lambrecht BN, Germonpre PR, Everaert EG, Carro-Muino I, De Veerman M, De Felipe C, Hunt SP, Thielemans K, Joos GF, Pauwels RA (1999) Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation. Eur J Immunol 29: 3815–3825

    Article  PubMed  CAS  Google Scholar 

  • Lilly CM, Bai TR, Shore SA, Hall AE, Drazen JM (1995) Neuropeptide content of lungs from asthmatic and nonasthmatic patients. Am J Respir Crit Care Med 151: 548–553

    PubMed  CAS  Google Scholar 

  • Lucchini RE, Facchini F, Turato G, Saetta M, Caramori G, Ciaccia A, Maestrelli P, Springall DR, Polak JM, Fabbri L, Mapp CE (1997) Increased VIP-positive nerve fibers in the mucous glands of subjects with chronic bronchitis. Am J Respir Crit Care Med 156: 1963–1968

    PubMed  CAS  Google Scholar 

  • Lundberg JM (1996) Pharmacology of cotransmission in the autonomic nervous system: integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide. Pharmacol Rev 48: 113–178

    PubMed  CAS  Google Scholar 

  • Lundberg JM, Hokfelt T, Martling C-R, Saria A, Cuello C (1984) Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell Tissue Res 235: 251–261

    Article  PubMed  CAS  Google Scholar 

  • Lundberg JM, Saria A (1983) Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants. Nature 302: 251–253

    Article  PubMed  CAS  Google Scholar 

  • Luts A, Uddman R, Aim P, Basterra J, Sundler F (1993) Peptide-containing nerve fibers in human airways: distribution and coexistence pattern. Int Arch Allergy Immunol 101: 52–60

    Article  PubMed  CAS  Google Scholar 

  • Maggi CA (1997) The effects of tachykinins on inflammatory and immune cells. Regul Pept 70: 75–90

    Article  PubMed  CAS  Google Scholar 

  • Maggi CA (2000) The troubled story of tachykinins and neurokinins. Trends Pharmacol Sci 21: 173–175

    Article  PubMed  CAS  Google Scholar 

  • Maghni K, Taha R, Afif W, Hamid Q, Martin JG (2000) Dichotomy between neurokinin receptor actions in modulating allergic airway responses in an animal model of helper T Cell type 2 cytokine-associated inflammation. Am J Respir Crit Care Med 162: 1068–1074

    PubMed  CAS  Google Scholar 

  • Mapp CE, Miotto D, Braccioni F, Saetta M, Turato G, Maestrelli P, Krause JE, Karpitskiy V, Boyd N, Geppetti P, Fabbri LM (2000) The distribution of neurokinin-1 and neurokinin-2 receptors in human central airways. Am J Respir Crit Care Med 161: 207–215

    PubMed  CAS  Google Scholar 

  • Martling C-R, Theodorsson-Norheim E, Lundberg JM (1987) Occurrence and effects of multiple tachykinins; substance P, neurokinin A and neuropeptide K in human lower airways. Life Sci 40: 1633–1643

    Article  PubMed  CAS  Google Scholar 

  • Naline E, Molimard M, Regoli D, Emonds-Alt X, Bellamy JF, Advenier C (1996) Evidence for functional tachykinin NK1 receptors on human isolated small bronchi. Am J Physiol 271: L763–L767

    PubMed  CAS  Google Scholar 

  • Nenan S, Germain N, Lagente V, Edmonds-Alt X, Advenier C, Boichot E (2001) Inhibition of inflammatory cell recruitment by the tachykinin NKrreceptor antagonist, SR 14280, in a murine model of asthma. Eur J Pharmacol 421: 210–205

    Article  Google Scholar 

  • Nieber K, Baumgarten CR, Rathsack R, Furkert J, Oehme P, Kunkel G (1992) Substance P and B-endorphine-like immunoreactivity in lavage fluids of subjects with and without allergic asthma. J Allergy Clin Immunol 90: 646–652

    Article  PubMed  CAS  Google Scholar 

  • Ollerenshaw SL, Jarvis D, Sullivan CE, Woolcock AJ (1991) Substance P immunoreactive nerves in airways from asthmatics and nonasthmatics. Eur Respir J 4: 673–682

    PubMed  CAS  Google Scholar 

  • Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS (2001) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 163: 1256–1276

    PubMed  CAS  Google Scholar 

  • Pedersen KE, Meeker SN, Riccio MM, Undem BJ (1998) Selective stimulation of jugular ganglion afferent neurons in guinea pig airways by hypertonic saline. J Appl Physiol 84: 499–506

    PubMed  CAS  Google Scholar 

  • Piedimonte G (2001) Neural mechanisms of respiratory syncytial virus-induced inflammation and prevention of respiratory syncytial virus sequelae. Am J Respir Crit Care Med 163: S18–S21

    PubMed  CAS  Google Scholar 

  • Piedimonte G, Hoffman JI, Husseini WK, Snider RM, Desai MC, Nadel JA (1993) NK1 receptors mediate neurogenic inflammatory increase in blood flow in rat airways. J Appl Physiol 74: 2462–2468

    PubMed  CAS  Google Scholar 

  • Piedimonte G, Rodriguez MM, King KA, McLean S, Jiang X (1999) Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs. Am J Physiol 277: L831–L840

    PubMed  CAS  Google Scholar 

  • Rumsey WL, Aharony D, Bialecki RA, Abbott BM, Barthlow HG, Caccese R, Ghanekar S, Lengel D, McCarthy M, Wenrich B, Undem B, Ohnmacht C, Shenvi A, Albert JS, Brown F, Bernstein PR, Russell K (2001) Pharmacological characterization of zd6021: a novel, orally active antagonist of the tachykinin receptors. J Pharmacol Exp Ther 298: 307–315

    PubMed  CAS  Google Scholar 

  • Saria A, Lundberg JM, Skofitsch G, Lembeck F (1983) Vascular protein leakage in various tissues induced by substance P, capsaicin, bradykinin, serotonin, histamine and by antigen challenge. Naunyn-Schmiedeberg’s Arch Pharmacol 324: 212–218

    Article  CAS  Google Scholar 

  • Schmidt D, Jorres RA, Rabe KF, Magnussen H (1996) Reproducibility of airway response to inhaled bradykinin and effect of the neurokinin receptor antagonist FK-224 in asthmatic subjects. Eur J Clin Pharmacol 50: 269–273

    Article  PubMed  CAS  Google Scholar 

  • Schelfhout, Louis R, Lenz W, Pauwels R, Joos G (2003) The triple neurokinin receptor antagonist CS-003 inhibits neurokinin A (NKA)-induced bronchoconstriction in patients with asthma. Eur Respir J 22(Suppl45): 415S

    Google Scholar 

  • Schuiling M, Zuidhof A, Meurs H, Zaagsma J (1999a) Role of tachykinin NK2-receptor activation in the allergen-induced late asthmatic react ion, airway hyper reactivity and airway inflammation cell influx in conscious, unrestrained guinea-pigs. Br J Pharmacol 127: 1030–1038

    Article  PubMed  CAS  Google Scholar 

  • Schuiling M, Zuidhof A, Zaagsma J, Meurs H (1999b) Involvement of tachykinin NK1 receptor in the development of allergen-induced airway hyperreactivity and airway inflammation in conscious, unrestrained guinea-pigs. Am J Respir Crit Care Med 159: 423–430

    PubMed  CAS  Google Scholar 

  • Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V (2002) The tachykinin peptide family. Pharmacol Rev 54: 285–322

    Article  PubMed  CAS  Google Scholar 

  • Snider RM, Constantine JW, Lowe III JA, Longo KP, Lebel WS, Woody HA, Drzda SE, Desai MC, Vinick FJ, Spence RW, Hess HJ (1991) A potent nonpeptide antagonist of the substance P (NK1) receptor. Science 251: 435–437

    Article  PubMed  CAS  Google Scholar 

  • Szarek JL, Zhang JZ, Gruetter CA (1993) 5-HT2 receptors augment cholinergic nerve-mediated contraction of rat bronchi. Eur J Pharmacol 231: 339–346

    Article  PubMed  CAS  Google Scholar 

  • Tanaka DT, Grunstein MM (1984) Mechanisms of substance P-induced contraction of rabbit airway smooth muscle. J Appl Physiol 57: 1551–1557

    PubMed  CAS  Google Scholar 

  • Tomaki M, Ichinose M, Miura M, Hirayama Y, Yamauchi H, Nakajima N, Shirato K (1995) Elevated substance P content in induced sputum from patients with asthma and patients with chronic bronchitis. Am J Respir Crit Care Med 151: 613–617

    PubMed  CAS  Google Scholar 

  • Tournoy KG, De Swert KO, Leclere PG, Lefebvre RA, Pauwels RA, Joos GF (2003) Modulatory role of tachykinin NK1 receptor in cholinergic contraction of mouse trachea. Eur Respir J 21: 3–10

    Article  PubMed  CAS  Google Scholar 

  • Tousignant C, Chan CC, Guevremont D, Brideau C, Hale JJ, Maccoss M, Rodger IW (1993) NK1 receptors mediate plasma extravasation in guinea-pig lower airways. Br J Pharmacol 108: 383–386

    Article  PubMed  CAS  Google Scholar 

  • van der Kleij HP, Ma D, Redegeld FA, Kraneveld AD, Nijkamp FP, Bienenstock J (2003) Functional expression of neurokinin 1 receptors on mast cells induced by IL-4 and stem cell factor. J Immunoll 71: 2074–2079

    Google Scholar 

  • Van Rensen EL, Hiemstra PS, Rabe KF, Sterk PJ (2002) Assessment of microvascular leakage via sputum induction: the role of substance P and neurokinin A in patients with asthma. Am J Respir Crit Care Med 165: 1275–1279

    Article  PubMed  Google Scholar 

  • Van Schoor J, Joos G, Chasson B, Brouard R, Pauwels R (1998) The effect of the NK1 receptor antagonist SR48968 (saredutant) on neurokinin A-induced bronchoconstrction in asthmatics. Eur Respir J 12: 17–23

    Article  PubMed  Google Scholar 

  • Van Schoor J, Joos GF, Pauwels RA (2000) Indirect bronchial hyperresponsiveness in asthma: mechanisms, pharmacology and implications for clinical research. Eur Respir J 16: 514–533

    Article  PubMed  Google Scholar 

  • Virchow JC, Julius P, Lommatzsch M, Luttmann W, Renz H, Braun A (1998) Neurotrophins are increased in bronchoalveolar lavage fluid after segmental allergen provocation. Am J Respir Crit Care Med 158: 2002–2005

    PubMed  CAS  Google Scholar 

  • Wu ZX, Lee LY (1999) Airway hyperresponsiveness induced by chronic exposure to cigarette smoke in guinea pigs: role of tachykinins. J Appl. Physiol 87: 1621–1628

    PubMed  CAS  Google Scholar 

  • Yang XX, PowellW S, Hojo M, Martin JG (1997) Hyperpnea-induced bronchoconstriction is dependent on tachykinin-induced cysteinyl leukotriene synthesis. J Appl Physiol 82: 538–544

    PubMed  CAS  Google Scholar 

  • Yoshihara S, Geppetti P, Hara M, Linden A, Ricciardolo FL, Chan B, Nadel JA (1996) Cold air-induced bronchoconstriction is mediated by tachykinin and kinin release in guinea pigs. Eur J Pharmacol 296: 291–296

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium

    G. F. Ioos

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  1. G. F. Ioos
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  1. Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitätsplatz 4, 8010, Graz, Austria

    Peter Holzer (Professor) (Professor)

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© 2004 Springer-Verlag Berlin Heidelberg

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Ioos, G.F. (2004). Role of Tachykinins in Obstructive Airway Disease. In: Holzer, P. (eds) Tachykinins. Handbook of Experimental Pharmacology, vol 164. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18891-6_15

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  • DOI: https://doi.org/10.1007/978-3-642-18891-6_15

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