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Nuclear Phosphoinositides and Their Functions

  • G. Hammond
  • C. L. Thomas
  • G. Schiavo
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 282)

Abstract

Phosphoinositides are minor components of biological membranes, which have emerged as essential regulators of a variety of cellular processes, both on the plasma membrane and on several intracellular organelles. The versatility of these lipids stems from their ability to function either as substrates for the generation of second messengers, as membrane-anchoring sites for cytosolic proteins or as regulators of the actin cytoskeleton. Despite a vast literature demonstrating the presence of phosphoinositides in the nucleus, only recently has the function(s) of the nuclear pool of these lipids and their soluble analogues, inositol polyphosphates, started to emerge. These compounds have been shown to serve as essential eo-factors for several nuclear processes, including DNA repair, transcription regulation and RNA dynamics. In this light, phosphoinositides and inositol polyphosphates might represent high turnover activity switches for nuclear complexes responsible for these processes. The regulation of these large machineries would be linked to the phosphorylation state of the inositol ring and limited temporally and spatially based on the synthesis and degradation of these molecules.

Keywords

Nuclear Envelope Phosphatidic Acid mRNA Export Dense Fibrillar Component Inositol Polyphosphates 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

DAG

Diacylglycerol

IGC

Interchromatin granule cluster

Ins

Inositol

PC

Phosphatidylcholine

PI

Phosphoinositides

PIPK

PtdInsP kinase

PLC

Phospholipase C

PKC

Protein kinase C

PtdIns

Phosphatidylinositol

RNA Pol II

RNA polymerase II

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • G. Hammond
    • 1
  • C. L. Thomas
    • 1
  • G. Schiavo
    • 1
  1. 1.Molecular NeuroPathoBiology Laboratory, Lincoln’s Inn Fields LaboratoriesCancer Research UK London Research InstituteLondonUK

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