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Strukturelle, zelluläre und subzelluläre Veränderungen des Gehirns bei physiologischem Altern und der senilen Demenz vom Alzheimer-Typ

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Molekularmedizinische Grundlagen von altersspezifischen Erkrankungen

Part of the book series: Molekulare Medizin ((MOLMED))

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Zusammenfassung

Zelluläre Altersveränderungen haben schon frühzeitig die Alterungsforschung beschäftigt. 1910 stellte Mühlmann die Hypothese auf, dass die Anhäufung des Alterspigments „Lipofuszin“ in Nervenzellen zu einer Nervenzelldegeneration führt. Nach seiner Theorie sollte das Leben in letzter Konsequenz in einem physiologischen Erschöpfungstod enden. Rund dreißig Jahre später zog die altersbedingte Abnahme des Wassergehalts des Gehirns das Interesse auf sich. Diesen Befund griff Max Bürger (1947) auf und baute ihn in sein Konzept der altersabhängigen Wasserverarmung bradytropher Gewebe ein. Die mit Wasserverlust einhergehende Abnahme des Hirngewichtes jenseits des 50. Lebensjahres (Roessle u. Roulet 1932) sah Bürger als Folge eines „Verdichtungsprozesses“ des Gehirns an. Diese Abnahme des Wassergehaltes betrachtete er als von hysteretischen Vorgängen begleitet, welche zur Bildung seniler Plaques und Alzheimer-Fibrillen führen sollten. Bürger beurteilte diese Vorgänge als geänderte kolloidchemische Prozesse.

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Authors
  1. William A. Meier-Ruge
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  2. Carlo Bertoni-Freddari
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  3. Patrizia Fattoretti
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  1. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Straße 10, 13122, Berlin-Buch, Germany

    Detlev Ganten  & Klaus Ruckpaul  & 

  2. Instituto Universitario de Investigación Gerontológica, Diego de León 62, E-28006, Madrid, Germany

    Antonio Ruiz-Torres

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Meier-Ruge, W.A., Bertoni-Freddari, C., Fattoretti, P. (2004). Strukturelle, zelluläre und subzelluläre Veränderungen des Gehirns bei physiologischem Altern und der senilen Demenz vom Alzheimer-Typ. In: Ganten, D., Ruckpaul, K., Ruiz-Torres, A. (eds) Molekularmedizinische Grundlagen von altersspezifischen Erkrankungen. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18741-4_5

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