Metastases in Head and Neck Cancer

pp 201-217

Cancer of Unknown Primary Sites

  • Jochen A. WernerAffiliated withDepartment of Otolaryngology, Head and Neck Surgery, Philipps University of Marburg
  • , R. Kim DavisAffiliated withUniversity of Utah, School of Medicine 3C 120 University Health Sciences Center

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The so-called CUP syndrome (cancer of unknown primary) is defined as one or more histologically proven metastases of a malignant tumor for which the localization cannot be determined in spite of intensive diagnostic measures [1].