Skip to main content
SpringerLink
Log in

Behavioral Improvement by Activation of Endogenous Progenitors in the Rat Transient Forebrain Ischemia Model

  • Conference paper
Maturation Phenomenon in Cerebral Ischemia V

  • 111 Accesses

Abstract

The recent discovery of neuronal progenitors capable of producing new neurons in adult mammals raises the possibility of repairing damaged tissue by recruiting their latent regenerative potentials. Recently, we showed that activation of endogenous progenitors by intraventricular infusion of a cocktail of FGF-2 and EGF, 2-5 days after ischemia, led to massive regeneration of hippocampal neurons after transient global ischemia in the adult rat forebrain. In this model, we investigated whether regenerated neurons can contribute to the intervention of neurological deficits caused by ischemic insults.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, Japan, 173-8605

    H. Nakatomi, A Tamura, N. Kawahara, T. Kirino & M. Nakafuku

Authors
  1. H. Nakatomi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Tamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Kawahara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Kirino
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Nakafuku
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Office of Stroke Research, Foothills Medical Centre, Rm 1162, 1403-29 Street N.W., Calgary, Alberta, T2N 2T9, Canada

    Alastair M. Buchan

  2. Department of Neurosurgery, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino-shu, Tokyo, 180-0023, Japan

    Umeo Ito

  3. Department of Psychology, University of Alberta, Edmonton, Alberta, T6G 2E9, Canada

    Fred Colbourne

  4. Department of Neuropathology Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku 113, Tokyo, Japan

    Toshihiko Kuroiwa

  5. Laboratory of Neuropathology and Neuroanatomical Sciences, NINDS, National Institutes of Health, Bethesda, Maryland, 20892-4128, USA

    Igor Klatzo

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Nakatomi, H., Tamura, A., Kawahara, N., Kirino, T., Nakafuku, M. (2004). Behavioral Improvement by Activation of Endogenous Progenitors in the Rat Transient Forebrain Ischemia Model. In: Buchan, A.M., Ito, U., Colbourne, F., Kuroiwa, T., Klatzo, I. (eds) Maturation Phenomenon in Cerebral Ischemia V. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18713-1_45

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-18713-1_45

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40874-1

  • Online ISBN: 978-3-642-18713-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation