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Mediastinal Staging

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Malignant Tumors of the Lung

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Abstract

It has been well known for more than 20 years that the involvement of the mediastinal lymph nodes is the most important prognostic marker in patients with localized, nonmetastatic lung cancer. The assessment of lymph node stage is hence a major step in the pretreatment workup to avoid unnecessary surgery in patients with poor survival expectancy.

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References

  • Akhurst T, Downey RJ, Ginsberg MS, et al. (2002) An initial experience with FDG-PET in the imaging of residual disease after induction therapy for lung cancer. Ann Thorac Surg 73:259–266

    Article  PubMed  Google Scholar 

  • Bueno R, Richards W, Swanson S, et al. (2000) Nodal stage after induction therapy for stage IIIA lung cancer determines patient survival. Ann Thorac Surg 70:1826–1831

    Article  PubMed  CAS  Google Scholar 

  • D’Amico TA, Wong TZ, Harpole DH, Brown SD, Coleman RE (2002) Impact of computed tomography-positron emission tomography fusion in staging patients with thoracic malignancies. Ann Thorac Surg 74:160–163

    Article  PubMed  Google Scholar 

  • De Giacomo T, Rendina EA, Venuta F, et al. (1997) Thoracoscopic staging of lIlB non-small cell lung cancer before neoadjuvant therapy. Ann Thorac Surg 64:1409–1411

    Article  PubMed  Google Scholar 

  • Depierre A, Milleron B, Moro-Sibilot D, et al. (2002) Preoperative chemotherapy followed by surgery compared with primary resection in resectable stage I (except T1NO), II, and IIIa non small cell lung cancer. J Clin Oncol 20:247–253

    Article  PubMed  Google Scholar 

  • Dunagan DP, Chin R, McCain T, et al. (2001) Staging by positron emission tomography predicts survival in patients with non-small cell lung cancer. Chest 119:333–339

    Article  PubMed  CAS  Google Scholar 

  • Eberhardt W, Wilke H, Stamatis G, et al. (1998) Preoperative chemotherapy followed by concurrent chemo-radiation therapy based on hyper fraction ated accelerated radiotherapy and definitive surgery in locally advanced non-small cell lung cancer: mature results of a phase II trial. J Clin Oncol 16:622–634

    PubMed  CAS  Google Scholar 

  • Fernando HC, Goldstraw P (1990) The accuracy of clinical evaluative intrathoracic staging in lung cancer as assessed by postsurgical pathologic staging. Cancer 65:2503–2506

    Article  PubMed  CAS  Google Scholar 

  • Garpestad E, Goldberg S, Herth F, et al. (2001) CT fluoroscopy guidance for transbronchial needle aspiration: an experience in 35 patients. Chest 119:329–332

    Article  PubMed  CAS  Google Scholar 

  • Gdeedo A, Van Schil P, Corthouts B, et al. (1997) Comparison of imaging TNM (iTNM) and pathological TNM (pTNM) in staging of bronchogenic carcinoma. Eur J Cardiothorac Surg 12:224–227

    Article  PubMed  CAS  Google Scholar 

  • Gdeedo A, Van Schil P, Corthouts B, et al. (1997) Prospective evaluation of computed tomography and mediastinoscopy in mediastinallymph node staging. Eur Resp J 10:1547–1551

    Article  CAS  Google Scholar 

  • Ginsberg RJ, Rice TW, Goldberg M, Waters PF, Schmocker BJ (1987) Extended cervical mediastinoscopy: a single staging procedure for bronchogenic carcinoma of the left upper lobe. J Thorac Cardiovasc Surg 94:673–678

    PubMed  CAS  Google Scholar 

  • Harrow EM, Abi-Saleh W, Blum J, et al. (2000) The utility of transbronchial needle aspiration in the staging of bronchogenic carcinoma. Am J Respir Crit Care Med 161:601–607

    Article  PubMed  CAS  Google Scholar 

  • Hunerbein M, Ghadimi BM, Haensch WW, Schlag PM (1998) Transesophageal biopsy of mediastinal and pulmonary tumors by means of endoscopic ultrasound guidance. J Thorac Cardiovasc Surg 116:554–559

    Article  PubMed  CAS  Google Scholar 

  • Larsen SS, Krasnik M, Vilmann P, et al. (2002) Endoscopic ultrasound guided biopsy of mediastinal lesions has a major impact on patient management. Thorax 57:98–103

    Article  PubMed  CAS  Google Scholar 

  • Kernstine KH, McLaughlin KE, Menda Y, et al. (2002) Can FDGPET reduce the need for mediastinoscopy in potentially resectable non-small cell lung cancer? Ann Thorac Surg 73:394–402

    Article  PubMed  Google Scholar 

  • Liptay MJ, Fry WA (1999) Complications from induction regimens for thoracic malignancies. Chest Surg Clin North Am 9:79–95

    CAS  Google Scholar 

  • Mateu-Navarro M, Rami-Porta R, Bastus-Piulats R, et al. (2000) Remediastinoscopy after induction chemotherapy in nonsmall cell lung cancer. Ann Thorac Surg 70:391–395

    Article  PubMed  CAS  Google Scholar 

  • Pass HI, Pogrebniak HW, Steinberg SM, Mulshine J, Minna J. (1992) Randomized trial of neoadjuvant therap y forlung cancer: interim analysis. Ann Thorac Surg 53:992–998

    Article  PubMed  CAS  Google Scholar 

  • Patelli M, Lazzari A, Poletti V, et al. (2002) Role of fiberscopic transbronchial needle aspiration in the staging of N2 disease due to non-small cell lung cancer. Ann Thorac Surg 73:407–411

    Article  PubMed  Google Scholar 

  • Pauwels M, Van Schil P, De Backer W, et al. (1995) Repeat media stinoscopy in the staging of lung cancer. Eur J Cardiothorac Surg 14:271–273

    Article  Google Scholar 

  • Pearson FG, Delarue NC, Ilves R. et al. (1982) Significance of positive superior mediastinal nodes identified at mediastinoscopy in pati ent s with resectable cancer of the lung. J Thorac Cardiovasc Surg 83:1–11

    PubMed  CAS  Google Scholar 

  • Poncelet AJ, Lonneux M, Coche E, Weynand B, Noirhomme P (2001) PET-FOGscan enhances but does not replace preoperative surgical staging in non-small cell lung carcinoma. Eur J Cardio-thorac Surg 20:468–475

    Article  CAS  Google Scholar 

  • Reed MF, Sugarbaker DJ (1996) Mediastinal staging of lung cancer. In: Pass HI et al. (eds) Lung cancer. Lippincott-Raven Press. 537–544

    Google Scholar 

  • Riquet M, Manac’h O, Saab M, Le Pimpec-Barthes F, Dujon A, Debesse B (1995) Factors determining survival in resected N2 lung cancer. Eur J Cardio-thorac Surg 9:300–304

    Article  CAS  Google Scholar 

  • Roeslin N, Warter A, Gasser B, et al. (1991) Non-anaplastic N2 operated bronchial cancers. Multifactorial analysis of prognosis (French) at. Ann Chir 45:673–678

    PubMed  CAS  Google Scholar 

  • Rosell R, Maestre J, Font A, et al. (1994) A randomized trial of mitomycin/ ifosfamide/cisplatin preoperative chemotherapy plus surgery versus surgery alone in stage IIIA non-small cell lung cancer. Semin Oncol 21:28–33

    PubMed  CAS  Google Scholar 

  • Roth JA, Fossella F, Komaki R. et al. (1994) A randomized trial comparing preoperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small cell lung cancer. J Nat! Cancer Inst 86:673–680

    Article  PubMed  CAS  Google Scholar 

  • Rusch VW, Albain KS, Crowley JJ, et al. (1993) Surgical resection of stage IIIA and stage IIIB non-small-cell lung cancer after concurrent induction chernoradiotherapy, A Southwest Oncology Group Trial. J Thorac Cardiovasc Surg 105:97–106

    PubMed  CAS  Google Scholar 

  • Ryu JS, Choi NC, Fischman AJ, et al. (2002) FOG-PET in staging and restaging non-small cell lung cancer after neoadjuvant chemoradiotherapy: correlation with histopathology. Lung Cancer 35:179–187

    Article  PubMed  Google Scholar 

  • Savage C, Morrison RJ, Zwischenberger JB (2001) Bronchoscopic diagnosis and staging of lung cancer. Chest Surg Clin North Am II:701–721

    Google Scholar 

  • Schaefer-Prokop C, Prokop M (2002) New imaging techniques in the treatment guidelines for lung cancer. Eur Respir J 19 (suppI35): 71s–83s

    Article  Google Scholar 

  • Stamatis G, Eberhardt W, Stuben G, et al. (1999) Preoperative chemoradiotherapy and surgery for selected non-small cell lung cancer IIIB subgroups: long-term result s. Ann Thorac Surg 68:1144–1149

    Article  PubMed  CAS  Google Scholar 

  • Therasse P, Arbuck SG, Eisenhauer EA, et al. (2000) New guidelines to evaluate the response to treatment in solid tumours. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States. National Cancer Institute of Canada. J Natl Cancer Inst 92:205–216

    Article  PubMed  CAS  Google Scholar 

  • Voltolini L, Luzzi L, Ghiribelli C, et al. (2001) Results of induction chemotherapy followed by surgical resection in patients with stage IIIA (N2) non-small cell lung cancer: the importance of the nodal down-staging after chemotherapy. Eur J Cardiothorae Surg 20:1106–1112

    Article  CAS  Google Scholar 

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Authors
  1. G Massard
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Editors and Affiliations

  1. Service de Médicine, Institut Jules Bordet, 1, rue Héger-Bordet, 1000, Bruxelles, Belgium

    Jean-Paul Sculier M.D., Ph.D.

  2. 1111 Sunset Road, Winnetka, IL, 60093, USA

    Willard A. Fry M.D.

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© 2004 Springer-Verlag Berlin Heidelberg

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Massard, G. (2004). Mediastinal Staging. In: Sculier, JP., Fry, W.A. (eds) Malignant Tumors of the Lung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18698-1_14

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  • DOI: https://doi.org/10.1007/978-3-642-18698-1_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62253-3

  • Online ISBN: 978-3-642-18698-1

  • eBook Packages: Springer Book Archive

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