Abstract
In recent years, we have accumulated a wealth of information concerning DNA damage induced by ionising radiation. It can be expected that the biochemistry of DNA repair pathways and the proteins involved will soon be elucidated in their entirety. In contrast, our knowledge on the impact of topology on the biological consequences of irradiation is still scarce. This is somewhat unexpected, as the importance of proximity of damaged sites for the generation of exchange-type aberrations had been acknowledged already in the earliest days of radiation biology [16]. One explanation for the lack of experimental data is that topology may affect induction and repair of damage on different levels, and that net-like interdependencies complicate the analysis of individual effects. In addition, because of lack of appropriate technologies until recently many topics could not be addressed experimentally. This article aims at reviewing our current knowledge on potential topological factors and remaining questions which are important for our radiobiological understanding.
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Friedl, A.A. (2004). Topological Factors in Radiation Biology. In: Kiefer, J. (eds) Life Sciences and Radiation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18687-5_6
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DOI: https://doi.org/10.1007/978-3-642-18687-5_6
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