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Colorectal Liver Metastases

  • H.-J. Gassel
  • M. Gasser
  • A.M. Waaga-Gasser
  • W. Timmermann

Abstract

The liver is the main site of manifestation of métastases of colorectal neoplasms. Diagnostic examination must address the primary tumor site, the extent of liver involvement and the presence of extrahepatic disease by endoscopy, ultrasound, computed tomography, chest x-ray and carcinogenic antigen (CEA) level assessment. Surgical resection represents the treatment of choice and is the only curative therapy at present. It should be performed for resectable métastases after exclusion of extrahepatic tumor (except pulmonary métastases), if the patient’s general health status and the remaining liver parenchyma are functionally sufficient. The achievement of a Ro status is the main prognostic factor. Adjuvant and neoadjuvant treatment protocols are under current investigation and cannot be recommended unless in clinical trials. Palliative options include chemotherapy (at present gold standard) and local ablative procedures, e.g. by radiofrequency or laser induced thermoablation and cryoablation. A close follow-up of the patients is necessary since secondary treatment can prolong survival.

Keywords

Liver Metastasis Liver Resection Colorectal Liver Metastasis Folinic Acid Colorectal Metastasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • H.-J. Gassel
    • 1
  • M. Gasser
    • 1
  • A.M. Waaga-Gasser
    • 2
  • W. Timmermann
    • 3
  1. 1.Bayerische Julius-Maximilians-Universität, Chirurgische UniversitätsklinikWürzburgGermany
  2. 2.Abt. für Molekulare Onkologie and ImmunologieBayerische Julius-Maximilians-Universität, Chirurgische UniversitätsklinikWürzburgGermany
  3. 3.Bayerische Julius-Maximilians-Universität, Chirurgische UniversitätsklinikWürzburgGermany

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