Carcinoma of the Gallbladder and Bile Ducts
Biliary tract cancers are rare tumors that have a poor prognosis. Predisposing conditions are characterized by chronic inflammatory and proliferative stimuli of the biliary epithelium. Despite a wealth of diagnostic tools, these cancers are often detected late due to their insidious symptomatic appearance. In patients with localized cancer, surgery is the only curative treatment option. In hilar bile duct tumors, an extended operation including partial hepatectomy may improve long-term outcome. Currently, there is no adjuvant or palliative radio- or chemotherapy available that has been shown to be effective. Treatment in patients with severe comorbidities or advanced stages of disease is directed towards palliation of symptoms. Endoscopic interventions like biliary decompression play a central role in palliative concepts. Prognosis is determined by disease stage and effective prevention of complications, prominent among them being cholangitis.
KeywordsBile Duct Primary Sclerosing Cholangitis Partial Hepatectomy Gallbladder Cancer Hepatic Duct
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