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Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

Lung fibrosis occurs in diverse clinical settings (Colby and Carrington 1995). Interstitial fibrosis is a non-specific pathological end-point that can occur as a consequence of granulomatous diseases (most commonly, sarcoidosis and tuberculosis), certain drug therapies and repeated exposure to organic or inorganic antigens (Seal et al. 1968; Fitzgerald et al. 1973; Gillett and Ford 1978). When there is widespread fibrosis, pulmonary physiology is generally abnormal and the typical finding on lung function testing is a restrictive functional deficit with abnormalities of gas transfer (Gibson 1996).

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References

  • Ashcroft T, Simpson JM, Timbrell V (1988) Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 41:467–470

    Article  PubMed  CAS  Google Scholar 

  • Bhalla M, Naidich DP, McGuinness G et al (1996) Diffuse lung disease: assessment with helical CT-preliminary observations of the role of maximum and minimum intensity projection images. Radiology 200:341–347

    PubMed  CAS  Google Scholar 

  • Bouros D, Wells AU, Nicholson AG et al (2002) Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome. Am J Respir Crit Care Med 165:1581–1586

    Article  PubMed  Google Scholar 

  • Brennan P, Silman A (1992) Statistical methods for assessing observer variability in clinical measures. Br Med J 304:1491–1494

    Article  CAS  Google Scholar 

  • Bruggen-Bogaarts BAHA van der, Broerse JJ, Lammers J-WJ et al (1995) Radiation exposure in standard and high-resolution chest CT scans. Chest 107:113–115

    Article  PubMed  Google Scholar 

  • Carrington CB, Gaensler EA, Mikus JP et al (1976) Structure and function in sarcoidosis. The BAL cooperative group steering committee. Ann NY Acad Sci 278:265–283

    Article  PubMed  CAS  Google Scholar 

  • Cherniack RM, Colby TV, Flint A et al (1991) Quantitative assessment of lung pathology in idiopathic pulmonary fibrosis. Am Rev Respir Dis 144:892–900

    Article  PubMed  CAS  Google Scholar 

  • Chinn S (1991) Repeatability and method comparison. Thorax 46:454–456

    Article  PubMed  CAS  Google Scholar 

  • Cochrane AL, Garland LH (1952) Observer error in the interpretation of chest films: an international investigation. Lancet 2:505–509

    Article  PubMed  CAS  Google Scholar 

  • Colby TV, Carrington CB (1995) Interstitial lung disease. In: Thurlbeck WM, Churg AM (eds) Pathology of the lung. Thieme, New York, pp 589–737

    Google Scholar 

  • Collins CD, Wells AU, Hansell DM et al (1994) Observer variation in pattern type and extent of disease in fibrosing alveolitis on thin section computed tomography and chest radiography. Clin Radiol 49:236–240

    Article  PubMed  CAS  Google Scholar 

  • Crystal RG, Fulmer JD, Roberts WC et al (1976) Idiopathic pulmonary fibrosis: clinical, histologic, radiographic, physiologic, scintigraphic, cytologic, and biochemical aspects. Ann Intern Med 85:769–788

    PubMed  CAS  Google Scholar 

  • Davison AG, Haslam PL, Corrin B et al (1983) Interstitial lung disease and asthma in hard-metal workers: bronchoalveolar lavage, ultrastructural, and analytical findings and results of bronchial provocation tests. Thorax 38:119–128

    Article  PubMed  CAS  Google Scholar 

  • Delorme S, Keller-Reichenbecher MA, Zuna I, Schlegel W, Van Kaick G (1997) Usual interstitial pneumonia. Quantitative assessment of high-resolution computed tomography findings by computer-assisted texture-based image analysis. Invest Radiol 32:566–574

    Article  PubMed  CAS  Google Scholar 

  • Desai SR, Hansell DM, Rubens MB et al (2000) A CT-derived composite physiological score as an indicator of prognosis in usual interstitial pneumonitis. Eur Radiol 10(Suppl 1): 186(A)

    Google Scholar 

  • Desai SR, Wells AU, Rubens MB et al (2003) Traction bronchiectasis in cryptogenic fibrosing alveolitis: associated computed tomographic features and physiological significance. Eur Radiol 13:1801–1808

    Article  PubMed  Google Scholar 

  • DiMarco AF, Briones B (1993) Is chest CT performed too often? Chest 103:985–986

    Article  PubMed  CAS  Google Scholar 

  • Epler GR, McLoud TC, Gaensler EA et al (1978) Normal chest roentgenograms in chronic diffuse infiltrative lung disease. N Engl J Med 298:934–939

    Article  PubMed  CAS  Google Scholar 

  • Fitzgerald MX, Carrington CB, Gaensler EA (1973) Environmental lung disease. Med Clin North Am 57:593–622

    PubMed  CAS  Google Scholar 

  • Fulmer JD, Roberts WC, von Gal ER (1979) Morphologic-physiologic correlates of the severity of fibrosis and degree of cellularity in idiopathic pulmonary fibrosis. J Clin Invest 63:665–676

    Article  PubMed  CAS  Google Scholar 

  • Gaensler EA, Carrington CB (1980) Open biopsy for chronic diffuse infiltrative lung disease: clinical, roentgenographic and physiological correlations in 502 patients. Ann Thorac Surg 30:411–426

    Article  PubMed  CAS  Google Scholar 

  • Gaensler EA, Carrington CB, Coutu RE et al (1972) Pathological, physiological, and radiological correlations in the pneumoconioses. Ann NY Acad Sci 200:574–607

    Article  PubMed  CAS  Google Scholar 

  • Gay SE, Kazerooni EA, Toews GB et al (1998) Idiopathic pulmonary fibrosis: predicting response to therapy and survival. Am J Respir Crit Care Med 157:1063–1072

    PubMed  CAS  Google Scholar 

  • Gibson GJ (1996) Alveolar diseases. In: Gibson GJ (ed) Clinical tests of respiratory function. Chapman and Hall, London, pp 223–247

    Google Scholar 

  • Gillett DG, Ford GT (1978) Drug-induced lung disease. Monogr Pathol 19:21–42

    PubMed  CAS  Google Scholar 

  • Gilman MJ, Laurens RG Jr, Somogyi JW et al (1983) CT attenuation values of lung density in sarcoidosis. J Comput Assist Tomogr 7:407–410

    Article  PubMed  CAS  Google Scholar 

  • Hansell DM (2001) Computed tomography of diffuse lung disease: functional correlates. Eur Radiol 11:1666–1680

    Article  PubMed  CAS  Google Scholar 

  • Hansell DM, Moskovic E (1991) High-resolution computed tomography in extrinsic allergic alveolitis. Clin Radiol 43:8–12

    Article  PubMed  CAS  Google Scholar 

  • Hansell DM, Wells AU, Padley SPG et al (1996) Hypersensitivity pneumonitis: correlation of individual CT patterns with functional abnormalities. Radiology 199:123–128

    PubMed  CAS  Google Scholar 

  • Hansell DM, Milne DG, Wilsher ML et al (1998) Pulmonary sarcoidosis: morphologic associations of airflow obstruction at thin-section CT. Radiology 209:697–704

    PubMed  CAS  Google Scholar 

  • Hapke EJ, Seal RME, Thomas GO et al (1968) Farmer’s lung: a clinical, radiographic, functional and serological correlation of acute and chronic stages. Thorax 23:451–468

    Article  PubMed  CAS  Google Scholar 

  • Hargreave F, Hinson KF, Reid L et al (1972) The radiological appearances of allergic alveolitis due to bird sensitivity (bird’s fancier’s lung). Clin Radiol 23:1–10

    Article  PubMed  CAS  Google Scholar 

  • Harrison BDW, Shaylor JM, Stokes TC et al (1991) Airflow limitation in sarcoidosis: a study of pulmonary function in 107 patients with newly diagnosed disease. Respir Med 85:59–64

    Article  PubMed  CAS  Google Scholar 

  • Harrison NK, Myers AR, Corrin B et al (1991) Structural features of interstitial lung disease in systemic sclerosis. Am Rev Respir Dis 144:706–713

    Article  PubMed  CAS  Google Scholar 

  • Hartley PG, Galvin JR, Hunninghake GW et al (1994) Highresolution CT-derived measures of lung density are valid indexes of interstitial lung disease. J Appl Physiol 76: 271–277

    PubMed  CAS  Google Scholar 

  • Heitmann KR, Kauczor H-U, Mildenberger P, Uthmann T, Perl J, Thelen M (1997) Automatic detection of ground glass opacities on lung HRCT using multiple neural networks. Eur Radiol 7:1463–1472

    Article  PubMed  CAS  Google Scholar 

  • Hirose N, Lynch DA, Cherniack RM et al (1993) Correlation between high resolution computed tomography and tissue morphometry of the lung in bleomycin-induced pulmonary fibrosis in the rabbit. Am Rev Respir Dis 147: 730–738

    PubMed  CAS  Google Scholar 

  • Hughes JC, O’Riordan MC (1993) Radiation exposure of the UK population-1993 review, 5th edn. National Radiation Protection Board. HMSO, Oxon

    Google Scholar 

  • Johnston IDA, Prescott RJ, Chalmers JC et al (1997) British Thoracic Society study of cryptogenic fibrosing alveolitis: current presentation and initial management. Thorax 52:38–44

    Article  PubMed  CAS  Google Scholar 

  • Kalender WA, Reinmuller R, Seissler W et al (1990) Measurement of parenchymal attenuation: use of Spirometric gating with quantitative CT. Radiology 175:265–268

    PubMed  CAS  Google Scholar 

  • Kalender WA, Fichte H, Bautz W et al (1991) Semiautomatic evaluation procedures for quantitative CT of the lung. J Comput Assist Tomogr 15:248–255

    Article  PubMed  CAS  Google Scholar 

  • Kaneko K, Sharma OP (1977) Airway obstruction in pulmonary sarcoidosis. Bull Eur Physiopath Resp 13:231–240

    CAS  Google Scholar 

  • Kirkwood BR (1988a) Means, standard deviations and standard errors. In: Kirkwood BR (ed) Essential of medical statistics. Blackwell, Oxford, pp 12–20

    Google Scholar 

  • Kirkwood BR (1988b) Multiple regression. In: Kirkwood BR (ed) Essential of medical statistics. Blackwell, Oxford, pp 65–72

    Google Scholar 

  • Lee KS, Primack SL, Staples CA et al (1994) Chronic infiltrative lung disease: comparison of diagnostic accuracies of radiography and low-and conventional-dose thin-section CT. Radiology 191:669–673

    PubMed  CAS  Google Scholar 

  • Longcope WT, Freiman DG (1952) A study of sarcoidosis based on a combined investigation of 160 cases including 30 autopsies from the Johns Hopkins Hospital and the Massachusetts General Hospital. Medicine (Baltimore) 31: 1–132

    Article  CAS  Google Scholar 

  • Lowe D (1993) Data summary. In: Lowe D (ed) Planning for medical research: a practical guide to research methods. Astraglobe, Middlesborough, pp 94–127

    Google Scholar 

  • Mayo JR, Jackson SA, Müller NL (1993) High-resolution CT of the chest: radiation dose. AJR 160:479–481

    PubMed  CAS  Google Scholar 

  • Mayo JR, Hartman TE, Lee KS et al (1995) CT of the chest: minimal tube current required for good image quality with the least radiation dose. AJR 164:603–607

    PubMed  CAS  Google Scholar 

  • Miller A, Teirstein AS, Jackler I et al (1974) Airway function in chronic pulmonary sarcoidosis with fibrosis. Am Rev Respir Dis 109:179–189

    PubMed  CAS  Google Scholar 

  • Molyneux AJ (1991) Computed tomography and radiation doses. Lancet 337:1164

    Article  PubMed  CAS  Google Scholar 

  • Müller NL, Miller RR, Webb WR et al (1986) Fibrosing alveolitis: CT-pathologic correlation. Radiology 160:585–588

    PubMed  Google Scholar 

  • Naidich DP, Marshall CH, Gribbin C et al (1990) Low-dose CT of the lungs: preliminary observations. Radiology 175: 729–731

    PubMed  CAS  Google Scholar 

  • Napel S, Rubin GD, Jeffrey RB Jr (1993) STS-MIP: a reconstruction technique for CT of the chest. J Comput Assist Tomogr 17:832–838

    Article  PubMed  CAS  Google Scholar 

  • Ng CS, Desai SR, Rubens MB et al (1999) Visual quantification and observer variation of signs of small airways disease at inspiratory and expiratory CT. J Thorac Imag 14:279–285

    Article  CAS  Google Scholar 

  • Pistolesi M, Miniati M, Milne ENC et al (1985) The chest roentgenogram in pulmonary edema. Clin Chest Med 6:315–344

    PubMed  CAS  Google Scholar 

  • Pistolesi M, Miniati M, Giuntini C (1988) A radiographic score for clinical use in the adult respiratory distress syndrome. Intensive Crit Care Dig 7:2–4

    Google Scholar 

  • Reger RB, Smith CA, Kibelstis JA et al (1972) The effect of film quality and other factors on the roentgenographic categorization of coal workers’ pneumoconiosis. AJR 115: 462–472

    CAS  Google Scholar 

  • Remy-Jardin M, Remy J, Wallaert B et al (1993) Subacute and chronic bird breeder hypersensitivity pneumonitis: sequential evaluation with CT and correlation with lung function tests and bronchoalveolar lavage. Radiology 189:111–118

    PubMed  CAS  Google Scholar 

  • Remy-Jardin M, Remy J, Artaud D et al (1996) Diffuse infiltrative lung disease: clinical value of sliding-thin-slab maximum intensity projection CT scans in the detection of mild micronodular patterns. Radiology 200:333–339

    PubMed  CAS  Google Scholar 

  • Robinson PJ, Kreel L (1979) Pulmonary tissue attenuation with computed tomography: comparison of inspiration and expiration scans. J Comput Assist Tomogr 3:740–748

    PubMed  CAS  Google Scholar 

  • Sakai F, Gamsu G, Im J-G et al (1987) Pulmonary function abnormalities in patients with CT-determined emphysema. J Comput Assist Tomogr 11:963–968

    Article  PubMed  CAS  Google Scholar 

  • Scano G, Monechi GC, Stendardi L et al (1986) Functional evaluation in stage I pulmonary sarcoidosis. Respiration 49:195–203

    Article  PubMed  CAS  Google Scholar 

  • Seal RME, Hapke EJ, Thomas GO et al (1968) The pathology of the acute and chronic stages of farmer’s lung. Thorax 23:469–489

    Article  PubMed  CAS  Google Scholar 

  • Selman-Lama M, Perez-Padilla R (1993) Airflow obstruction and airway lesions in hypersensitivity pneumonitis. Clin Chest Med 14:699–714

    PubMed  CAS  Google Scholar 

  • Sider L, Dennis L, Smith LJ et al (1987) CT of the lung parenchyma and the pulmonary function test. Chest 92:406–410

    Article  PubMed  CAS  Google Scholar 

  • Siegel S, Castellan NJ Jr (1989) Measures of association and their tests of significance. In: Siegel S, Castellan NJ Jr (eds) Nonparametric statistics for the behavioural sciences. McGraw-Hill, New York, pp 284–291

    Google Scholar 

  • Silver SF, Müller NL, Miller RR et al (1989) Hypersensitivity pneumonitis: evaluation with CT. Radiology 173:441–445

    PubMed  CAS  Google Scholar 

  • Staples CA, Müller NL, Vedal S et al (1987) Usual interstitial pneumonia: correlation of CT with clinical, functional, and radiologic findings. Radiology 162:377–381

    PubMed  CAS  Google Scholar 

  • Sutinen S, Reijula K, Huhti E et al (1983) Extrinsic allergic bronchiolo-alveolitis: serology and biopsy findings. Eur J Respir Dis 64:271–282

    PubMed  CAS  Google Scholar 

  • Travis WD, King TE Jr, and the Multidisciplinary Core Panel (2002) American Thoracic Society/European Respiratory Society international multidisciplinary consensus classification of idiopathic interstitial pneumonias. Am J Respir Crit Care Med 165:277–304

    Google Scholar 

  • Tuddenham WJ (1963) Problems in perception in chest roentgenology: facts and fallacies. Radiol Clin North Am 1:277–289

    Google Scholar 

  • Turner-Warwick M, Burrows B, Johnson A (1980) Cryptogenic fibrosing alveolitis: clinical features and their influence on survival. Thorax 35:171–180

    Article  PubMed  CAS  Google Scholar 

  • Udwadia ZF, Pilling JR, Jenkins PF et al (1990) Bronchoscopic and bronchographic findings in 12 patients with sarcoidosis and severe or progressive airways obstruction. Thorax 45:272–275

    Article  PubMed  CAS  Google Scholar 

  • Watters LC, King TE, Schwarz MI et al (1986) A clinical, radiographic, and physiologic scoring system for the longitudinal assessment of patients with idiopathic pulmonary fibrosis. Am Rev Respir Dis 133:97–103

    PubMed  CAS  Google Scholar 

  • Wells AU, Cullinan P, Hansell DM et al (1994) Fibrosing alveolitis associated with systemic sclerosis has a better prognosis than lone cryptogenic fibrosing alveolitis. Am J Respir Crit Care Med 149:1583–1590

    PubMed  CAS  Google Scholar 

  • Wells AU, Hansell DM, Rubens MB et al (1997a) Functional impairment in lone cryptogenic fibrosing alveolitis and fibrosing alveolitis associated with systemic sclerosis: a comparison. Am J Respir Crit Care Med 155:1657–1664

    PubMed  CAS  Google Scholar 

  • Wells AU, King AD, Rubens MB et al (1997b) Lone cryptogenic fibrosing alveolitis: a functional-morphologic correlation based on the extent of disease on thin-section computed tomography. Am J Respir Crit Care Med 155:1367–1375

    PubMed  CAS  Google Scholar 

  • Wells AU, Desai SR, Rubens MB et al (2003) Idiopathic pulmonary fibrosis: a composite physiologic index devived from disease extent observed by computed tomography. Am J Respir Crit Care Med 167:962–969

    Article  PubMed  Google Scholar 

  • Wright PH, Heard BE, Steel SJ et al (1981) Cryptogenic fibrosing alveolitis: assessment by graded trephine lung biopsy histology compared with clinical, radiographic, and physiological features. Br J Dis Chest 75:61–70

    Article  PubMed  CAS  Google Scholar 

  • Zwirewich CV, Mayo JR, Müller NL (1991) Low-dose high-resolution CT of lung parenchyma. Radiology 180:413–417

    PubMed  CAS  Google Scholar 

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Desai, S.R. (2004). CT Imaging. In: Kauczor, HU. (eds) Functional Imaging of the Chest. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18621-9_6

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  • DOI: https://doi.org/10.1007/978-3-642-18621-9_6

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