Abstract
Lung fibrosis occurs in diverse clinical settings (Colby and Carrington 1995). Interstitial fibrosis is a non-specific pathological end-point that can occur as a consequence of granulomatous diseases (most commonly, sarcoidosis and tuberculosis), certain drug therapies and repeated exposure to organic or inorganic antigens (Seal et al. 1968; Fitzgerald et al. 1973; Gillett and Ford 1978). When there is widespread fibrosis, pulmonary physiology is generally abnormal and the typical finding on lung function testing is a restrictive functional deficit with abnormalities of gas transfer (Gibson 1996).
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References
Ashcroft T, Simpson JM, Timbrell V (1988) Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 41:467–470
Bhalla M, Naidich DP, McGuinness G et al (1996) Diffuse lung disease: assessment with helical CT-preliminary observations of the role of maximum and minimum intensity projection images. Radiology 200:341–347
Bouros D, Wells AU, Nicholson AG et al (2002) Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome. Am J Respir Crit Care Med 165:1581–1586
Brennan P, Silman A (1992) Statistical methods for assessing observer variability in clinical measures. Br Med J 304:1491–1494
Bruggen-Bogaarts BAHA van der, Broerse JJ, Lammers J-WJ et al (1995) Radiation exposure in standard and high-resolution chest CT scans. Chest 107:113–115
Carrington CB, Gaensler EA, Mikus JP et al (1976) Structure and function in sarcoidosis. The BAL cooperative group steering committee. Ann NY Acad Sci 278:265–283
Cherniack RM, Colby TV, Flint A et al (1991) Quantitative assessment of lung pathology in idiopathic pulmonary fibrosis. Am Rev Respir Dis 144:892–900
Chinn S (1991) Repeatability and method comparison. Thorax 46:454–456
Cochrane AL, Garland LH (1952) Observer error in the interpretation of chest films: an international investigation. Lancet 2:505–509
Colby TV, Carrington CB (1995) Interstitial lung disease. In: Thurlbeck WM, Churg AM (eds) Pathology of the lung. Thieme, New York, pp 589–737
Collins CD, Wells AU, Hansell DM et al (1994) Observer variation in pattern type and extent of disease in fibrosing alveolitis on thin section computed tomography and chest radiography. Clin Radiol 49:236–240
Crystal RG, Fulmer JD, Roberts WC et al (1976) Idiopathic pulmonary fibrosis: clinical, histologic, radiographic, physiologic, scintigraphic, cytologic, and biochemical aspects. Ann Intern Med 85:769–788
Davison AG, Haslam PL, Corrin B et al (1983) Interstitial lung disease and asthma in hard-metal workers: bronchoalveolar lavage, ultrastructural, and analytical findings and results of bronchial provocation tests. Thorax 38:119–128
Delorme S, Keller-Reichenbecher MA, Zuna I, Schlegel W, Van Kaick G (1997) Usual interstitial pneumonia. Quantitative assessment of high-resolution computed tomography findings by computer-assisted texture-based image analysis. Invest Radiol 32:566–574
Desai SR, Hansell DM, Rubens MB et al (2000) A CT-derived composite physiological score as an indicator of prognosis in usual interstitial pneumonitis. Eur Radiol 10(Suppl 1): 186(A)
Desai SR, Wells AU, Rubens MB et al (2003) Traction bronchiectasis in cryptogenic fibrosing alveolitis: associated computed tomographic features and physiological significance. Eur Radiol 13:1801–1808
DiMarco AF, Briones B (1993) Is chest CT performed too often? Chest 103:985–986
Epler GR, McLoud TC, Gaensler EA et al (1978) Normal chest roentgenograms in chronic diffuse infiltrative lung disease. N Engl J Med 298:934–939
Fitzgerald MX, Carrington CB, Gaensler EA (1973) Environmental lung disease. Med Clin North Am 57:593–622
Fulmer JD, Roberts WC, von Gal ER (1979) Morphologic-physiologic correlates of the severity of fibrosis and degree of cellularity in idiopathic pulmonary fibrosis. J Clin Invest 63:665–676
Gaensler EA, Carrington CB (1980) Open biopsy for chronic diffuse infiltrative lung disease: clinical, roentgenographic and physiological correlations in 502 patients. Ann Thorac Surg 30:411–426
Gaensler EA, Carrington CB, Coutu RE et al (1972) Pathological, physiological, and radiological correlations in the pneumoconioses. Ann NY Acad Sci 200:574–607
Gay SE, Kazerooni EA, Toews GB et al (1998) Idiopathic pulmonary fibrosis: predicting response to therapy and survival. Am J Respir Crit Care Med 157:1063–1072
Gibson GJ (1996) Alveolar diseases. In: Gibson GJ (ed) Clinical tests of respiratory function. Chapman and Hall, London, pp 223–247
Gillett DG, Ford GT (1978) Drug-induced lung disease. Monogr Pathol 19:21–42
Gilman MJ, Laurens RG Jr, Somogyi JW et al (1983) CT attenuation values of lung density in sarcoidosis. J Comput Assist Tomogr 7:407–410
Hansell DM (2001) Computed tomography of diffuse lung disease: functional correlates. Eur Radiol 11:1666–1680
Hansell DM, Moskovic E (1991) High-resolution computed tomography in extrinsic allergic alveolitis. Clin Radiol 43:8–12
Hansell DM, Wells AU, Padley SPG et al (1996) Hypersensitivity pneumonitis: correlation of individual CT patterns with functional abnormalities. Radiology 199:123–128
Hansell DM, Milne DG, Wilsher ML et al (1998) Pulmonary sarcoidosis: morphologic associations of airflow obstruction at thin-section CT. Radiology 209:697–704
Hapke EJ, Seal RME, Thomas GO et al (1968) Farmer’s lung: a clinical, radiographic, functional and serological correlation of acute and chronic stages. Thorax 23:451–468
Hargreave F, Hinson KF, Reid L et al (1972) The radiological appearances of allergic alveolitis due to bird sensitivity (bird’s fancier’s lung). Clin Radiol 23:1–10
Harrison BDW, Shaylor JM, Stokes TC et al (1991) Airflow limitation in sarcoidosis: a study of pulmonary function in 107 patients with newly diagnosed disease. Respir Med 85:59–64
Harrison NK, Myers AR, Corrin B et al (1991) Structural features of interstitial lung disease in systemic sclerosis. Am Rev Respir Dis 144:706–713
Hartley PG, Galvin JR, Hunninghake GW et al (1994) Highresolution CT-derived measures of lung density are valid indexes of interstitial lung disease. J Appl Physiol 76: 271–277
Heitmann KR, Kauczor H-U, Mildenberger P, Uthmann T, Perl J, Thelen M (1997) Automatic detection of ground glass opacities on lung HRCT using multiple neural networks. Eur Radiol 7:1463–1472
Hirose N, Lynch DA, Cherniack RM et al (1993) Correlation between high resolution computed tomography and tissue morphometry of the lung in bleomycin-induced pulmonary fibrosis in the rabbit. Am Rev Respir Dis 147: 730–738
Hughes JC, O’Riordan MC (1993) Radiation exposure of the UK population-1993 review, 5th edn. National Radiation Protection Board. HMSO, Oxon
Johnston IDA, Prescott RJ, Chalmers JC et al (1997) British Thoracic Society study of cryptogenic fibrosing alveolitis: current presentation and initial management. Thorax 52:38–44
Kalender WA, Reinmuller R, Seissler W et al (1990) Measurement of parenchymal attenuation: use of Spirometric gating with quantitative CT. Radiology 175:265–268
Kalender WA, Fichte H, Bautz W et al (1991) Semiautomatic evaluation procedures for quantitative CT of the lung. J Comput Assist Tomogr 15:248–255
Kaneko K, Sharma OP (1977) Airway obstruction in pulmonary sarcoidosis. Bull Eur Physiopath Resp 13:231–240
Kirkwood BR (1988a) Means, standard deviations and standard errors. In: Kirkwood BR (ed) Essential of medical statistics. Blackwell, Oxford, pp 12–20
Kirkwood BR (1988b) Multiple regression. In: Kirkwood BR (ed) Essential of medical statistics. Blackwell, Oxford, pp 65–72
Lee KS, Primack SL, Staples CA et al (1994) Chronic infiltrative lung disease: comparison of diagnostic accuracies of radiography and low-and conventional-dose thin-section CT. Radiology 191:669–673
Longcope WT, Freiman DG (1952) A study of sarcoidosis based on a combined investigation of 160 cases including 30 autopsies from the Johns Hopkins Hospital and the Massachusetts General Hospital. Medicine (Baltimore) 31: 1–132
Lowe D (1993) Data summary. In: Lowe D (ed) Planning for medical research: a practical guide to research methods. Astraglobe, Middlesborough, pp 94–127
Mayo JR, Jackson SA, Müller NL (1993) High-resolution CT of the chest: radiation dose. AJR 160:479–481
Mayo JR, Hartman TE, Lee KS et al (1995) CT of the chest: minimal tube current required for good image quality with the least radiation dose. AJR 164:603–607
Miller A, Teirstein AS, Jackler I et al (1974) Airway function in chronic pulmonary sarcoidosis with fibrosis. Am Rev Respir Dis 109:179–189
Molyneux AJ (1991) Computed tomography and radiation doses. Lancet 337:1164
Müller NL, Miller RR, Webb WR et al (1986) Fibrosing alveolitis: CT-pathologic correlation. Radiology 160:585–588
Naidich DP, Marshall CH, Gribbin C et al (1990) Low-dose CT of the lungs: preliminary observations. Radiology 175: 729–731
Napel S, Rubin GD, Jeffrey RB Jr (1993) STS-MIP: a reconstruction technique for CT of the chest. J Comput Assist Tomogr 17:832–838
Ng CS, Desai SR, Rubens MB et al (1999) Visual quantification and observer variation of signs of small airways disease at inspiratory and expiratory CT. J Thorac Imag 14:279–285
Pistolesi M, Miniati M, Milne ENC et al (1985) The chest roentgenogram in pulmonary edema. Clin Chest Med 6:315–344
Pistolesi M, Miniati M, Giuntini C (1988) A radiographic score for clinical use in the adult respiratory distress syndrome. Intensive Crit Care Dig 7:2–4
Reger RB, Smith CA, Kibelstis JA et al (1972) The effect of film quality and other factors on the roentgenographic categorization of coal workers’ pneumoconiosis. AJR 115: 462–472
Remy-Jardin M, Remy J, Wallaert B et al (1993) Subacute and chronic bird breeder hypersensitivity pneumonitis: sequential evaluation with CT and correlation with lung function tests and bronchoalveolar lavage. Radiology 189:111–118
Remy-Jardin M, Remy J, Artaud D et al (1996) Diffuse infiltrative lung disease: clinical value of sliding-thin-slab maximum intensity projection CT scans in the detection of mild micronodular patterns. Radiology 200:333–339
Robinson PJ, Kreel L (1979) Pulmonary tissue attenuation with computed tomography: comparison of inspiration and expiration scans. J Comput Assist Tomogr 3:740–748
Sakai F, Gamsu G, Im J-G et al (1987) Pulmonary function abnormalities in patients with CT-determined emphysema. J Comput Assist Tomogr 11:963–968
Scano G, Monechi GC, Stendardi L et al (1986) Functional evaluation in stage I pulmonary sarcoidosis. Respiration 49:195–203
Seal RME, Hapke EJ, Thomas GO et al (1968) The pathology of the acute and chronic stages of farmer’s lung. Thorax 23:469–489
Selman-Lama M, Perez-Padilla R (1993) Airflow obstruction and airway lesions in hypersensitivity pneumonitis. Clin Chest Med 14:699–714
Sider L, Dennis L, Smith LJ et al (1987) CT of the lung parenchyma and the pulmonary function test. Chest 92:406–410
Siegel S, Castellan NJ Jr (1989) Measures of association and their tests of significance. In: Siegel S, Castellan NJ Jr (eds) Nonparametric statistics for the behavioural sciences. McGraw-Hill, New York, pp 284–291
Silver SF, Müller NL, Miller RR et al (1989) Hypersensitivity pneumonitis: evaluation with CT. Radiology 173:441–445
Staples CA, Müller NL, Vedal S et al (1987) Usual interstitial pneumonia: correlation of CT with clinical, functional, and radiologic findings. Radiology 162:377–381
Sutinen S, Reijula K, Huhti E et al (1983) Extrinsic allergic bronchiolo-alveolitis: serology and biopsy findings. Eur J Respir Dis 64:271–282
Travis WD, King TE Jr, and the Multidisciplinary Core Panel (2002) American Thoracic Society/European Respiratory Society international multidisciplinary consensus classification of idiopathic interstitial pneumonias. Am J Respir Crit Care Med 165:277–304
Tuddenham WJ (1963) Problems in perception in chest roentgenology: facts and fallacies. Radiol Clin North Am 1:277–289
Turner-Warwick M, Burrows B, Johnson A (1980) Cryptogenic fibrosing alveolitis: clinical features and their influence on survival. Thorax 35:171–180
Udwadia ZF, Pilling JR, Jenkins PF et al (1990) Bronchoscopic and bronchographic findings in 12 patients with sarcoidosis and severe or progressive airways obstruction. Thorax 45:272–275
Watters LC, King TE, Schwarz MI et al (1986) A clinical, radiographic, and physiologic scoring system for the longitudinal assessment of patients with idiopathic pulmonary fibrosis. Am Rev Respir Dis 133:97–103
Wells AU, Cullinan P, Hansell DM et al (1994) Fibrosing alveolitis associated with systemic sclerosis has a better prognosis than lone cryptogenic fibrosing alveolitis. Am J Respir Crit Care Med 149:1583–1590
Wells AU, Hansell DM, Rubens MB et al (1997a) Functional impairment in lone cryptogenic fibrosing alveolitis and fibrosing alveolitis associated with systemic sclerosis: a comparison. Am J Respir Crit Care Med 155:1657–1664
Wells AU, King AD, Rubens MB et al (1997b) Lone cryptogenic fibrosing alveolitis: a functional-morphologic correlation based on the extent of disease on thin-section computed tomography. Am J Respir Crit Care Med 155:1367–1375
Wells AU, Desai SR, Rubens MB et al (2003) Idiopathic pulmonary fibrosis: a composite physiologic index devived from disease extent observed by computed tomography. Am J Respir Crit Care Med 167:962–969
Wright PH, Heard BE, Steel SJ et al (1981) Cryptogenic fibrosing alveolitis: assessment by graded trephine lung biopsy histology compared with clinical, radiographic, and physiological features. Br J Dis Chest 75:61–70
Zwirewich CV, Mayo JR, Müller NL (1991) Low-dose high-resolution CT of lung parenchyma. Radiology 180:413–417
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Desai, S.R. (2004). CT Imaging. In: Kauczor, HU. (eds) Functional Imaging of the Chest. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18621-9_6
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DOI: https://doi.org/10.1007/978-3-642-18621-9_6
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