Abstract
The concept of immunological surveillance against cancer is based on the postulate of Paul Ehrlich (1909) that tumour cells arise with enormous frequency, and that they are normally eliminated by immune mechanisms. Burnet (1970) has restated it in modern terms. One of the arguments of immunologic surveillance is the infiltration of primary tumours by lymphocytes and macrophages. In human carcinomas, an impairment of unspecific cellular defence, represented chiefly by the macrophage system, seems to play an important role as shown by Kohout (1972) using the skin window test of Rebuck and Crowley (1955). In the mouse, endotoxin-mediated necrosis and regression of established tumours may be mediated by the tumour necrosis factor (TNF) probably released by activated macrophages (Mac Pherson and North 1986).
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© 2004 Springer-Verlag Berlin Heidelberg
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Schiller, E. (2004). Formulation of the Problems. In: Free Radicals and Inhalation Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18619-6_4
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DOI: https://doi.org/10.1007/978-3-642-18619-6_4
Publisher Name: Springer, Berlin, Heidelberg
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