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Carcinogens Target Cell Respiration and Induce Glycolysis

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Cancer — Between Glycolysis and Physical Constraint

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Abstract

Genetic instability has been implicated prominently in tumor formation. The main evidence comes first from the discovery of chromosomal aberrations and then from mutations of oncogenes or tumor suppressor genes. These anomalies of the genome are usually not a primary event but secondary to stress of extracellular origin such as hypoxia or physical constraints. Carcinogens (either viral, chemical, or physical) target cell respiration and induce glycolysis. Thus carcinogens mimic hypoxia and induce mutations.

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Authors and Affiliations

  1. Service de radiothérapie-cancérologie Hôpital de la Pitié-Salpétrière, 73 Boulevard de l’hôpital, 75013, Paris, France

    Laurent Schwartz

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  1. Laurent Schwartz
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© 2004 Springer-Verlag Berlin Heidelberg

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Schwartz, L. (2004). Carcinogens Target Cell Respiration and Induce Glycolysis. In: Cancer — Between Glycolysis and Physical Constraint. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18543-4_9

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  • DOI: https://doi.org/10.1007/978-3-642-18543-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20496-1

  • Online ISBN: 978-3-642-18543-4

  • eBook Packages: Springer Book Archive

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