Abstract
Whether it is untreated pneumonia, an unremoved foreign body like a splinter, or cardiac insufficiency resistant to treatment, all chronic inflammation progresses toward fibrosis. Hepatitis is another example: either inflammation disappears or the disease become chronic and evolves toward cirrhosis.One of the consequences of hypoxia is the secretion of extracellular matrix, particularly of collagen. These deposits perpetuate hypoxia, alter tissue architecture, and further damage the genome.
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Schwartz, L. (2004). Fibrosis Perpetuates Hypoxia. In: Cancer — Between Glycolysis and Physical Constraint. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18543-4_7
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DOI: https://doi.org/10.1007/978-3-642-18543-4_7
Publisher Name: Springer, Berlin, Heidelberg
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