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Sequence-Specific Cleavage of Double-Stranded DNA

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Artificial Nucleases

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 13))

Abstract

Double-stranded DNA is the main form of genetic storage material in living organisms. For this reason it represents an attractive target for genetic modification and gene-directed therapy. In contrast to the antisense treatment (Uhlmann and Peyman 1990), direct modification of a target gene renders the results of this treatment irreversible if repair processes do not reverse the reaction. A cleavage of a single site within chromosomal DNA opens the possibility for the artificial control of gene expression at the whole genome level. Basic principles of construction of such sequence-selective DNA-cleaving reagents have been reviewed by Hélène 10 years ago (Hélène 1993).

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Authors and Affiliations

  1. Laboratoire de Biophysique, Muséum National d’Histoire Naturelle, INSERM U565 — CNRS UMR 8646, 43 rue Cuvier, 75231, Paris Cedex 05, France

    A. S. Boutorine & P. B. Arimondo

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  1. A. S. Boutorine
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  2. P. B. Arimondo
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  1. Novosibirsk Institute of Bioorganic Chemistry, 8, Lavrentiev ave., 630090, Novosibirsk, Russia

    Marina A. Zenkova

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Boutorine, A.S., Arimondo, P.B. (2004). Sequence-Specific Cleavage of Double-Stranded DNA. In: Zenkova, M.A. (eds) Artificial Nucleases. Nucleic Acids and Molecular Biology, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18510-6_14

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  • DOI: https://doi.org/10.1007/978-3-642-18510-6_14

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