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Operation of a DNA-Based Autocatalytic Network in Serum

  • Elton Graugnard
  • Amber Cox
  • Jeunghoon Lee
  • Cheryl Jorcyk
  • Bernard Yurke
  • William L. Hughes
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6518)

Abstract

The potential for inferring the presence of cancer by the detection of miRNA in human blood has motivated research into the design and operation of DNA-based chemical amplifiers that can operate in bodily fluids. As a first step toward this goal, we have tested the operation of a DNA-based autocatalytic network in human serum and mouse serum. With the addition of sodium dodecyl sulfate to prevent degradation by nuclease activity, the network was found to operate successfully with both DNA and RNA catalysts.

Keywords

Sodium Dodecyl Sulfate Mouse Serum Human Blood Serum Strand Invasion Autocatalytic System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Elton Graugnard
    • 1
  • Amber Cox
    • 1
  • Jeunghoon Lee
    • 2
  • Cheryl Jorcyk
    • 3
  • Bernard Yurke
    • 1
    • 4
  • William L. Hughes
    • 1
  1. 1.Materials Science & EngineeringBoise State UniversityBoiseUSA
  2. 2.Chemistry & BiochemistryBoise State UniversityBoiseUSA
  3. 3.Biological SciencesBoise State UniversityBoiseUSA
  4. 4.Electrical & Computer EngineeringBoise State UniversityBoiseUSA

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