Abstract
Factor VIII inhibitors occur in 15–25% of patients with severe hemophilia A while being substituted with factor VIII concentrates, as well as spontaneously in non- hemophiliac individuals. The latter usually are young women, who develop a factor VIII inhibitor either during pregnancy or more likely postpartum, or elderly patients with a predisposing concomitant disease such as rheumatoid arthritis, systemic lupus erythematosus, or non-Hodgkin’s lymphoma [1]. Non-hemophiliac patients with acquired factor VIII inhibitors often show a more severe bleeding tendency than hemophiliacs, with a lethality rate of 22% [1]. Intra-articular bleedings are rare in this patient group.
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© 2001 Springer-Verlag Berlin Heidelberg
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Mohren, M., Jakob, A., Kanz, L., Jaschonek, K. (2001). Acquired Hemophilia in Women Postpartum. In: Scharrer, I., Schramm, W. (eds) 30th Hemophilia Symposium Hamburg 1999. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18240-2_56
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DOI: https://doi.org/10.1007/978-3-642-18240-2_56
Publisher Name: Springer, Berlin, Heidelberg
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