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Report on Experience in the Treatment of Hepatitis C in HIV-Coinfected Hemophiliacs

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30th Hemophilia Symposium Hamburg 1999
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Abstract

Hepatitis C and HIV represent global health problems. To date, over 35 million people have become infected with HIV. The hepatitis C virus is found generally in 1–3% of the population with an assumed worldwide number of between 60 and 180 million infected persons. Coinfection with hepatitis C virus and HIV frequently occurs because of the same route of transmission via blood and blood products. This applies especially to drug addicts and hemophiliacs. In Germany it is estimated that there are about 5600 HIV/HCV-coinfected patients. In view of the rapid progress of hepatitis C in the presence of HIV infection, especially in advanced immunodeficiency, treatment of hepatitis C in the presence of HIV coinfection is becoming increasingly important. Up to now, however, the poor therapeutic success and considerable side effects of the current forms of treatment (especially interferon-α monotherapy) have been limiting factors. The following paper deals with the data so far collected on the therapeutic possibilities for hepatitis C in HIV- infected hemophiliacs.

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References

  1. Bochet M, Benhamon Y, Colombat G, et al: Anti-protease inhibitor therapy decreases the liver fibrosis progression rate in HIV-HCV coinfected patients. In: Program and Abstracts of the 7th European Conference on Clinical Aspects and Treatment of HIV-Infection, Lisbon, 1999; 33:248

    Google Scholar 

  2. Busch C, Nagabhairu L, Markowitz M, et al: Changes in HCV viral load in HIV patients during HAART therapy and after therapy failure. In: Program and Abstracts of the 6th Conference on Retroviruses and Opportunistic Infections, Chicago, 1999; 192

    Google Scholar 

  3. De Sanctis GM, Errera G, Barbacini G, et al: Long-term outcome of chronic hepatitis infection in HIV± subjects treated with interferon. In: Program and Abstracts of the 9th International Conference on AIDS, Berlin, Germany, 1993:B19

    Google Scholar 

  4. Eyster ME, Fried MB, Di Bisceglie AM, et al: Increasing hepatitis C virus RNA levels in hemophiliacs: Relationship to human immunodeficiency virus infection and liver disease. Blood 1994;84:1020–1023

    PubMed  CAS  Google Scholar 

  5. Marcellin P, Boyer N, Areias J, et al: Comparison of efficacy of α-interferon in former intravenous drug addicts with chronic hepatitis with or without HIV-infection. Gastroenterology 1994; 106:A938

    Google Scholar 

  6. Mariott E, Navas S, del Romero I et al: Treatment with combinant α-interferon of chronic hepatitis C in anti-HIV-positive patients. J Med Virol 1993; 40:107–111

    Article  Google Scholar 

  7. Mauss S, Klinker H, Ulmer A, Willers R, Weißbrich B, Albrecht H, Häussinger D, Jablonowski H: Response to treatment of chronic hepatitis C with interferon a in patients infected with HIV-1 is associated with higher CD4-cell count. Infection 1998; 26:16–19

    Article  PubMed  CAS  Google Scholar 

  8. Piliero PJ, Szebenyi S, Bartholomew C, et al: Recombinant interferon therapy for chronic hepatitis C in patients with HIV. In: Program and Abstracts of the 4th Conference on Retroviruses and Opportunistic Infections, Washington, 1997:673

    Google Scholar 

  9. Reichard O, Norkrans G, Fryden A, et al: Randomized double-blind placebo-controlled trial of interferon-α 2b with and without ribavirin for chronic hepatitis C. Lancet 1998; 351:83–87

    Article  PubMed  CAS  Google Scholar 

  10. Rockstroh JK, Theisen A, Kaiser R et al: Antiretroviral triple therapy decreases HIV-viral load but does not alter hepatitis C virus serum levels in HIV/HCV-coinfected hemophiliacs. AIDS 1998; 12:829–830

    PubMed  CAS  Google Scholar 

  11. Soriano V, Garcia-Samaniego J, Bravo R, et al: Interferon-α for the treatment of chronic hepatitis C in patients infected with human immunodeficiency virus. Clin Infect Dis 1996; 23:585–591

    Article  PubMed  CAS  Google Scholar 

  12. Zylberberg H, Landau A, Chai XML, et al: Ribavirin does not modify HIV-replication in HCV/HIV-coinfected subjects under antiretroviral regimen. Hepatology 1998; 28:479a

    Google Scholar 

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© 2001 Springer-Verlag Berlin Heidelberg

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Rockstroh, J.K. (2001). Report on Experience in the Treatment of Hepatitis C in HIV-Coinfected Hemophiliacs. In: Scharrer, I., Schramm, W. (eds) 30th Hemophilia Symposium Hamburg 1999. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18240-2_5

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  • DOI: https://doi.org/10.1007/978-3-642-18240-2_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-67677-5

  • Online ISBN: 978-3-642-18240-2

  • eBook Packages: Springer Book Archive

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