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30th Hemophilia Symposium Hamburg 1999 pp 240–260Cite as

Prevalence of Common Mutations and Polymorphisms of the Genes of FII, FV, FVII, FXII, FXIII, MTHFR and ACE — Identified As Risk Factors for Venous and Arterial Thrombosis — in Germany and Different Ethnic Groups (Indians, Blacks) of Costa Rica

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Abstract

Several genetic variants are currently identified as risk factors for venous and arterial thrombosis (deep venous thrombosis, myocardial infarction and stroke). Activated protein C resistance due to the factor V Leiden (FVL) and the 20210 G>A mutation in the factor II (FII, Prothrombin) gene are well-established causes of thrombophilia. Concerning the risk of myocardial infarction and stroke the results are different: There are studies reporting positive (Ma et al. 1996; Montaruli et al. 1996; Nabavi et al. 1998; Simioni et al. 1995; Arruda et al. 1997; Doggen et al. 1998; Rosendaal et al. 1997; Watzke et al. 1997; Corral et al. 1997) or neutral influences (Ardissino et al. 1996; Sanchez et al. 1997; Schröder et al. 1999; Corral et al. 1997; Kapur et al. 1997; Eikelboom et al. 1998; Ferraresi et al. 1997; Prohaska et al. 1999). The 677C>T mutation in the methylenetetrahydrofolate reductase gene (677C>T MTHFR), which caused a mild hyperhomocysteinemia is considered as a risk factor for coronary heart disease (Kluijtmans et al. 1996; Morita et al. 1997), venous thrombosis and stroke (Margaglione et al. 1998; Kluijtmans et al. 1999), but the results are controversial.

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Authors
  1. F. H. Herrmann
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  2. L. Salazar-Sanchez
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  3. K. Wulff
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  4. R. Grimm
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  5. G. Schuster
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  6. G. Jimmez-Aru
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  7. M. Chavez
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  8. W. Schröder
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Editor information

Editors and Affiliations

  1. Hemophilia Center, Dept. of Internal Medicine, University Hospital, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany

    Inge Scharrer

  2. Dept. of Hemostasiology, University Hospital, Ziemssenstr. 1a, D-80336, München, Germany

    Wolfgang Schramm

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© 2001 Springer-Verlag Berlin Heidelberg

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Herrmann, F.H. et al. (2001). Prevalence of Common Mutations and Polymorphisms of the Genes of FII, FV, FVII, FXII, FXIII, MTHFR and ACE — Identified As Risk Factors for Venous and Arterial Thrombosis — in Germany and Different Ethnic Groups (Indians, Blacks) of Costa Rica. In: Scharrer, I., Schramm, W. (eds) 30th Hemophilia Symposium Hamburg 1999. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18240-2_34

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  • DOI: https://doi.org/10.1007/978-3-642-18240-2_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-67677-5

  • Online ISBN: 978-3-642-18240-2

  • eBook Packages: Springer Book Archive

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