Abstract
The risk of thromboembolic complications is considerably less for newborns and children than adults for any given insult, due to lower plasma concentrations of vitamin K-dependent coagulation factors, i.e., prothrombin, and contact factors [1, 2]. The capacity of newborn plasma to generate thrombin is decreased to 30–50% of adult values [3, 4]. In addition, alpha2-macroglobulin (α2-M) has been suggested as a major anticoagulant protein in infancy and has been demonstrated to complex up to 49% of generated alpha thrombin in newborn plasma [5, 6]. On the other hand, α2-M has been shown to bind activated protein C (APC) [7], one of the most important anticoagulant proteins. In addition, increased complex formation between α2-M and APC has been demonstrated to be associated with an unfavorable outcome in patients suffering from disseminated intravascular coagulation (DIC) [8], suggesting that α2-M might abrogate the anticoagulant action of APC. Previously, we have demonstrated a dose-dependent anticoagulant effect of APC in newborn and adult plasma using the determination of thrombin generation (thrombin potential, TP)
Keywords
- Disseminate Intravascular Coagulation
- Disseminate Intravascular Coagulation
- Thrombin Generation
- Anticoagulant Action
- Prothrombin Activation
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Cvirn, G., Gallistl, S., Kutschera, J., Muntean, W. (2001). Anticoagulant Action of Activated Protein C is Diminished by Alpha2-Macroglobulin in Newborn Plasma. In: Scharrer, I., Schramm, W. (eds) 30th Hemophilia Symposium Hamburg 1999. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18240-2_10
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DOI: https://doi.org/10.1007/978-3-642-18240-2_10
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