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Molecular Cytogenetic Characterization of a Critical Region in Bands 7q35-q36 Commonly Deleted in Malignant Myeloid Disorders

  • Conference paper
Acute Leukemias VIII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 40))

Abstract

Cytogenetic studies have shown loss of chromosome 7 (−7) or deletions of the long arm (7q-) in various tumor types. These findings suggest that chromosome 7 harbours tumor suppressor genes which play a role in the pathogenesis of these malignancies (Atkin et al. 1993; Zenklusen et al. 1996). In particular, in myeloid disorders loss of -7/7q- are among the most frequent chromosome abnormalities. These aberrations are associated with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), in particular with therapy-related MDS/AML (t-MDS/t-AML) following therapy with alkylating agents or secondary MDS/AML after occupational exposure to chemical mutagens (Le Beau et al. 1986).

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Author information

Authors and Affiliations

  1. Department of Internal Medicine V, University of Heidelberg, Hospitalstraße 3, 69115, Heidelberg, Germany

    K. DÖhner, U. Hehmann, J. Brown, C. Hetzel, C. Scholl, S. FrÖhling & H. DÖhner

  2. Duncan Guthrie Institute of Medical Genetics, Glasgow, Scotland

    J. Stewart & G. Lowther

  3. Dipartimento di Scienze Biomediche e Terapie Avanzate Univerista Degli Studi di Ferrara, Italy

    A. Cuneo

  4. The Department of Genetics, The Hospital for Sick Children, Toronto, Canada

    L. C. Tsui & S. W. Scherer

  5. Department“Organisation of Complex Genomes”, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany

    P. Lichter

Authors
  1. K. DÖhner
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  2. U. Hehmann
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  3. J. Brown
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  4. C. Hetzel
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  5. J. Stewart
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  6. G. Lowther
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  7. C. Scholl
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  8. S. FrÖhling
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  9. A. Cuneo
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  10. L. C. Tsui
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  11. P. Lichter
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  12. S. W. Scherer
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  13. H. DÖhner
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine A, Germany

    T. Büchner

  2. Department of Internal Medicine III, University Hospital Großhadern Ludwig-Maximilians-University, Marchioninistr. 15, 81377, München, Germany

    W. Hiddemann

  3. Dept. of Internal Medicine, University of Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany

    B. Wörmann

  4. Department of Pediatrics, University of Münster, Albert-Schweitzer-Straße 33, 48149, Münster, Germany

    G. Schellong , J. Ritter  & U. Creutzig ,  & 

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© 2001 Springer-Verlag Berlin Heidelberg

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DÖhner, K. et al. (2001). Molecular Cytogenetic Characterization of a Critical Region in Bands 7q35-q36 Commonly Deleted in Malignant Myeloid Disorders. In: Büchner, T., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J., Creutzig, U. (eds) Acute Leukemias VIII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18156-6_3

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  • DOI: https://doi.org/10.1007/978-3-642-18156-6_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62109-3

  • Online ISBN: 978-3-642-18156-6

  • eBook Packages: Springer Book Archive

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