Zusammenfassung
Epidemiologie Weltweit werden jährlich 1,3 Mio. Neuerkrankungen verzeichnet, die Tendenz ist steigend [27]. Bei Männern macht das BC 22 % aller Karzinome aus, bei Frauen kommt es mit 8 % gleich hinter dem Mammakarzinom. Der Anteil des NSCLC (Non-Small Cell Lung Cancer, nichtkleinzelliges Bronchialkarzinom) beträgt 80 % an den Bronchialkarzinomen und 18 % an allen Karzinomen; das kleinzellige hält einen Anteil von ca. 20 %. Jährlich sterben 45 000 Menschen am Bronchialkarzinom, jeder 20. Mann in Deutschland ist betroffen.
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Literatur
Al-Sugair A, Coleman RE (1998) Applications of PET in Lung Cancer. Semin Nucl Med 28: 303–319
Antoch G, Stattaus J, Nemat AT et al. (2003) Non-small cell lung cancer: Dual modality PET/CT in preoperative staging. Radiology 229: 526–533
Baldwin SA (1993) Mammalian passive glucose transporters: members of an ubiquitous familiy of active and passive transport proteins. Bioch Biophys Acta 1154: 17–49
Baum RP, Hellwig D, Mezzetti M (2004) Position of nuclear medicine modalities in the diagnostic workup of cancer patients: lung cancer. Q J Nucl Med Mol Imaging 48: 119–142
Briele B, Willkomm P, Grünwald F et al. (1999) Darstellung sekundärer pulmonaler Veränderungen bei zentralen Bronchialkarzinomen in der F-18-FDG-PET. Nuklearmedizin 38: 323
Brink I, Schumacher T, Mix M et al. (2004) Impact of [18F]FDG-PET on the primary staging of small cell lung cancer. Eur J Nucl Med Mol Imaging 31: 1614–1620
Czernin J (Guest Editor) (2007) PET/CT in cancer patient management. J Nucl Med: 1S–88S
Czernin J, Auerbach MA (2005) Clinical PET/CT imaging: Promises and misconceptions. Nuklearmedizin 44 (Suppl 1): S18–23
Czernin J, Weber W (2004) Translational molecular imaging. Molecular Imaging Biol 6: 183–187
Czernin J, Allen-Auerbach M, Schelbert HR (2007) Improvements in cancer staging with PET/CT: Literature-based evidence as of September 2006. J Nucl Med 48 (Suppl 1): 78S–88S
Dietlein M, Weber K, Grandjour A et al. (2000) Cost-effectiveness of FDG-PET for the management of solitary pulmonary nodules: a decision analysis based on cost reimbursement in Germany. Eur J Nucl Med 27: 1441–1456
Dietlein M, Moka D, Weber K et al (2001) Kosteneffektivität der PET im Behandlungsalgorithmus der Lungentumoren: Ein Vergleich gesundheitsökonomischer Daten. Nuklearmedizin 40: 122–128
DKG (2008) Kurzgefasste interdisziplinäre Leitlinien 2008. Deutsche Krebsgesellschaft. http://www.krebsgesellschaft.de/wub_llkurz_2008,120883.html. Zugegriffen: 25. Januar 2010
Erasmus JE, Page McAdams H, Connolly JE (2000) Solitary pulmonary nodules: Part II. Evaluation of the indeterminate nodule. Radiographics 20: 69–66
Erasmus JJ, Page Mc Adams H, Rossi SE, Goodman PC et al. (2000) FDG PET of pleural effusions in patients with non-small cell lung cancer. Am J Roentgenol 175: 245–249
Experts Multidisciplinary (2003) Thoracic disease site committee’s research strategy. http://www.acrin.org/lung_strategyhtml. Zugegriffen: 2006
Farrel MA, McAdams HP, Herndon JE, Patz EF jr. (2000) Non-small cell lung cancer: FDG PET for nodal staging in patients with stage I disease. Radiology 215: 886–890
Fowler J (2002) Nuclear medicine chemistry. J Nucl Med 42: 14N
Gambhir SS, Czernin J, Schwimmer J et al. (2001) A tabulated summary of the FDG PET Literature. J Nucl Med (Suppl) 42: 1–93
Gerbaudo VH, Sugarbaker DJ, Britz-Cunningham S et al. (2002) Assessment of malignant pleural mesothelioma with 18F-FDG dual-head gamma-camera coincidence imaging: comparison with histopathology. J Nucl Med 43: 1144–1149
Goerres GW, von Schulthess GK, Steinert HC (2004) Why most PET of lung and head neck cancer will be PET/CT. J Nucl Med (Suppl 1) 45: 66S–71S
Hammerschmidt S, Wirtz H (2009) Lungenkarzinom – aktuelle Diagnostik und Therapie. Dt Ärztebl 49: 809–818
Hauber HP, Bohuslavicki KH, Lund CH et al. (2001) Positron emission tomography in the staging of small cell lung cancer-a preliminary study. Chest 119: 950–954
Hicks RJ, Kalff V, MacManus MP et al. (2001) The utility of 18F-FDG PET for suspected recurrent non-small cell lung cancer after potentially curative therapy: Impact on management and prognostic stratification. J Nucl Med 42: 1605–1613
Higashi K, Ueda Y, Ayabe K et al. (2000) FDG PET in the evaluation of the aggressiveness of pulmonary adenocarcinoma: correlation with histopathological features. Nucl Med Comm 21: 707–714
Iagaru A, Chavla S, Menendez L, Conti P (2006) 18F-FDG PET and PET/CT for detection of pulmonary metastases from musculoskeletal sarcomas. Nucl Med Comm 27: 795
Jemal A, Murray T, Ward E (2005) Cancer Statistics 2005. CA Cancer J Clin 55: 10–30
Kagna O, Solomonov A, Keidar Z et al. (2009) The value of FDGPET/ CT in assessing single pulmonary nodules in patients at high risk of lung cancer. Eur J Nucl Med Mol Imaging 36: 997
Keidar Z, Haim N, Guralnik L et al. (2004) PET/CT using 18F-FDG in suspected lung cancer recurrence: diagnostic value and impact on patient management. J Nucl Med 45: 1640–1646
Klett R, Röhrl A, Bauer R (2000) Nächtliche und belastungsbedingte pektanginöse Beschwerden durch vertebragene Dysfunktion. Herz/Kreislauf 32: 309–311
Knopp MV, Strauss LG, Dimitrakopoulou A et al. (1991) Positron emission tomography (PET ) in oncology – Its contribution for the diagnostic and therapeutic management of patients. In: Höfer R, Bergamnn H, Sinzinger H (Hrsg) Schattauer, Stuttgart, S 522–523
Krishnasetty V, Fischman AJ, Halpern EL, Aquino SL (2005) Comparison of alignment of computer-registered data sets: Combined PET/CT versus independent PET and CT of the thorax. Radiology 237: 635–639
Krüger S, Buck AK, Mottaghy FM et al. (2009) Detection of bone metastases in patients with lung cancer: 99mTc-MDP planar bone scintigraphy, 18F-fluoride PET or 18F-FDG PET/CT. Eur J Nucl Med Mol Imaging 36: 1807
Kubota K, Matsuzawa T, Fujiwara T et al (1990) Differential diagnosis of lung tumor with positron emission tomography: A prospective study. J Nucl Med 31: 1927–1933
Lardinois D, Weder W, Hany TF et al. (2003) Staging of non-small cell lung cancer with integrated positron emission tomography and computed tomography. N Engl J Med 348: 2500–2507
Lee J, Aronchick JM, Alavi A (2001) Accuracy of F-18 fluordeoxyglucose positron emission tomography for the evalation of malignancy in patients presenting with new lung abnormalities. Chest 120: 1791–1797
Marom EM, Erasmus JE, Patz jr EF (2000) Lung cancer and positron emission tomography with fluorodeoxyglucose. Lung Cancer 28: 187–202
Marom EM, Sarvis S, Herndon JE et al. (2002) T1 lung cancers: Sensitivity of diagnosis with fluorodeoxyglucose PET. Radiology 223: 453–459
Nakamoto Y, Tatsumi M, Cohade C et al. (2003) Accuracy of image fusion of normal upper abdominal organs visualized with PET/ CT. Eur J Nucl Med Mol Imaging 30: 597–602
Ost D, Fein A (2000) Evaluation and management of the solitary pulmonary nodule. Am J Respir Crit Care Med 162: 782–787
van Overhage H, Broekel K, Heijenbrok MW et al. (2004) Metastases in supraclavicular lymphnodes in lung cancer: Assessment with palpation, US and CT. Radiology 232: 75–80
Pandit N, Gonen M, Krug L, Larson SM (2003) Prognostic value of [18F]FDG-PET imaging in small cell lung cancer. Eur J Nucl Med Mol Imaging 30: 78–84
Pauls S, Buck AK, Hohl K et al. (2007) Improved non-invasive T-staging in non-small cell lung cancer by integrated 18F-FDG PET/CT. Nuklearmedizin 46: 9–14
Pieterman RM, van Putten JWG, Meuzelaar JJ et al. (2000) Preoperative staging of non-small-cell lung cancer with Positron-Emission-Tomography. N Engl J Med 343: 245–261
Reske S, Kotzerke J (2001) FDG-PET for clinical use. Results of the 3rd German Interdisciplinary Consensus Conference, »Onko-PET III«, 21 July and 19 September 2000. Eur J Nucl Med 28: 1707– 1723
Rösch F (2004) Radionuklid-Generatorsysteme für die PET. Der Nuklearmediziner 27: 226–235
Schaffler GJ, Wolf G, Schoellnast H et al. (2004) Non-small cell lung cancer: Evaluation of pleural abnormalities on CT scans with 18F FDG PET. Radiology 231: 858–865
von Schulthess GK (2004) Maximizing the benefit of integrated PET/CT: the road ahead. Eur J Nucl Med Mol Imaging 31: 1462– 1463
Skoura EV, Exarhos D, Skilakaki M et al. (2009) Contribution of 18F-PET/CT in the management of patients with bronchioalveolar carcinoma (BAC): work in progress. Eur J Nucl Med Mol Imaging, Abstracts Ann Congr EANM 2009: P118, S333
Soriano Castrejon A, Garcia Vicente AM, Talavera Rubio MP et al. (2008) (18)F-FDG PET/CT respiratory gating of pulmonary lesions with low uptake: approximations towards clinical indicatins (Abstr). Nuklearmedizin 48: A145
Steinert HC (2004) PET und PET/CT beim Lungenkarzinom. Der Nuklearmediziner 27: 278–287
Thibault H, Derumeaux G (2008) Assessment of myocardial ischemia and viability using tissue Doppler and deformation imaging:the lessons from the experimental studies. Arch Cardiovasc Dis 101(1): 61
Thie JA (2004) Understanding the standardized uptake value, its methods, and implications for usage. J Nucl Med 45: 1431–1434
van Tinteren H, Hoekstra OS, Smit EF et al. (2002) Effectiveness of positron emission tomography in the preoperative assessment of patients with suspected non small cell lung cancer: The PLUS multicentre randomized trial. Lancet 359: 1388–1392
Vahlensieck M (2000) Der pulmonale Rundherd – Dignitätsbeurteilung durch CT. Dt Ärztebl 97: C1871
Vansteenkiste JF, Mortelsman LA (1999) FDG-PET in the locoregional lymphnode staging of non-small cell lung cancer: a comprehensive review of the Leuven lung cancer group experience. Clin Pos Imag 2: 223–231
Wahl A, Buck AK, Mueller A et al. (2004) CT, PET and PET/CT image fusion for the evaluation of suspicious pulmonary nodules and for staging NSCLC (Abstr. 10). Eur J Nucl Med Mol Imaging (Suppl 2) 31: S204–S205
Wahl RL (2004) Why nearly all PET of abdominal and pelvic cancers will be performed as PET/CT. J Nucl Med (Suppl 1) 45: 82S–95S
Weber W, Dietlein M, Hellwig D, Kirsch C, Schicha H, Schwaiger M (2003) PET with 18F-fluordeoxyglucose for staging of non-smallcell lung cancer: Evidence-based recommendations and cost-effectivness. Nuklearmedizin 46: S135–S144
Wester HJ (2004) Entwicklung von PET-Tracern zur in-vivo-Charakterisierung der Tumorbiologie. Der Nuklearmediziner 27: 218–225
Yi CA, Lee KS, Kim BT et al. (2006) Tissue characterization of solitary pulmonary nodule: Comparative study between helical dynamic CT and integrated PET/CT. J Nucl Med 47: 443
Zhao DS, Valdivia AY, Li Y, Blaufox MD (2002) 18F-fluorodeoxyglucose positron emission tomography in small-cell lung cancer. Semin Nucl Med 32: 272–275
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Mohnike, W., Hör, G., Schelbert, H. (2011). Pneumologie. In: PET/CT-Atlas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-17805-4_5
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