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Quantitative Modeling of Neuronal Dynamics in C. elegans

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Part of the Lecture Notes in Computer Science book series (LNTCS,volume 6443)


We present a mathematical model to quantitatively describe the neuronal dynamics in Caenorhabditis elegans. Since calcium imaging is a popular technique to visualize the neuronal activity in C. elegans, the model includes the variable of the fluorescence intensity in addition to the membrane potential and the intracellular calcium concentration. The fluorescence intensity is a quantity which is comparable with the experimental data. The parameters in the model are determined to reproduce the neurophysiological experimental data. Our model exhibits good agreement with the data. We apply the model to a neural circuit for chemotaxis and find that the neuronal activity measured by the fluorescence intensity shows quantitatively different behavior from that measured by the membrane potential in some neurons. The difference is discussed from the viewpoint of neuronal mechanisms.


  • C. elegans
  • membrane potential
  • intracellular calcium concentration
  • fluorescence intensity
  • chemotaxis circuit

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  • DOI: 10.1007/978-3-642-17537-4_3
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Kuramochi, M., Iwasaki, Y. (2010). Quantitative Modeling of Neuronal Dynamics in C. elegans . In: Wong, K.W., Mendis, B.S.U., Bouzerdoum, A. (eds) Neural Information Processing. Theory and Algorithms. ICONIP 2010. Lecture Notes in Computer Science, vol 6443. Springer, Berlin, Heidelberg.

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  • Print ISBN: 978-3-642-17536-7

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