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Diabetes - Perspectives in Drug Therapy pp 331–356Cite as

Mitochondria as Potential Targets in Antidiabetic Therapy

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 203))

Abstract

A growing body of evidence suggests that mitochondrial abnormalities are involved in diabetes and associated complications. This chapter gives an overview about the effects of diabetes in mitochondrial function of several tissues including the pancreas, skeletal and cardiac muscle, liver, and brain. The realization that mitochondria are at the intersection of cells’ life and death has made them a promising target for drug discovery and therapeutic interventions. Here, we also discuss literature that examined the potential protective effect of insulin, insulin-sensitizing drugs, and mitochondrial-targeted antioxidants.

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Authors and Affiliations

  1. Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517, Coimbra, Portugal

    Paula I. Moreira & Catarina R. Oliveira

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  1. Paula I. Moreira
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  2. Catarina R. Oliveira
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Correspondence to Paula I. Moreira or Catarina R. Oliveira .

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  1. Fakultät Lebenswissenschaften Molekulare Pharmakologie und Toxikologie, Technische Universität Braunschweig, Beethovenstraße 55, 38106, Braunschweig, Germany

    Mathias Schwanstecher

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Moreira, P.I., Oliveira, C.R. (2011). Mitochondria as Potential Targets in Antidiabetic Therapy. In: Schwanstecher, M. (eds) Diabetes - Perspectives in Drug Therapy. Handbook of Experimental Pharmacology, vol 203. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-17214-4_14

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