Skip to main content
SpringerLink
Log in

Pharmakodynamik und Pharmakokinetik beim Intensivpatienten, Interaktionen

  • Chapter
Die Intensivmedizin

  • 7166 Accesses

Zusammenfassung

Die Pharmakodynamik beschreibt die Einflüsse eines Pharmakons auf den Organismus, befasst sich also mit der Art und Weise seiner biologischen Wirkungen. Sie beinhaltet Überlegungen zu Wirkungsmechanismen, Rezeptortheorien, Dosis-Wirkungs-Beziehungen und Nebenwirkungen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Alexander JK, Dennis EW, Smith WG, Amad KH, Duncan WC, Austin RC (1962) Blood volume, cardiac output, and disposition of systemic blood flow in extreme obesity. Cardiovasc Res Cent Bull 1: 39–44

    PubMed  Google Scholar 

  2. Avasthi G, Sandhu JS, Mohindra K (2003) Acute renal failure in medical and surgical intensive care units a one year prospective study. Ren Fail 25: 105–113.

    Article  PubMed  Google Scholar 

  3. Aveling W, Brandshaw AD Crankshaw DP (1978) The effect of speed of injection on the potency of anaesthetic induction agents. Anaesth Intens Care 6: 116–119

    CAS  Google Scholar 

  4. Baylis C, Corman B (1998) The aging kidney: Insights from experimental studies. J Am Soc Nephrol 9: 699–709

    PubMed  CAS  Google Scholar 

  5. Bovill JG (1997) Adverse drug interactions in anesthesia. J Clin Anesth 9: 3S-13S

    Article  PubMed  CAS  Google Scholar 

  6. Bowman, SL, Hudson SA, Simpson G, Munro JF, Clements JA (1986) A comparison of the pharmacokinetics of propanolol in obese and normal volunteers. Br J Clin Pharmacol 21: 529–532

    PubMed  CAS  Google Scholar 

  7. Brivet FG, Kleinknecht DJ, Loirat P, Landais PJ (1996). Acute renal failure in intensive care units – causes, outcome, and prognostic factors of hospital mortality; a prospective, multicenter study. French Study Group on Acute Renal Failure. Crit Care Med 24: 192–198

    Article  PubMed  CAS  Google Scholar 

  8. Cheymol, G (1987) Comparative pharmacokinetics of intravenous propanolol in obese and normal volunteers. J Clin Pharmacol 27: 874–879

    PubMed  CAS  Google Scholar 

  9. Derry CL, Kroboth PD, Pittenger AL, Kroboth FJ, Corey SE, Smith RB (1995) Pharmacokinetics and pharmacodynamics of triazolam after two intermittent doses in obese and normal-weight men. J Clin Psychopharmacol 15: 197–205

    Article  PubMed  CAS  Google Scholar 

  10. Dettli L (1973) Translation of pharmacokinetics to clinical medicine. J Pharmacokinet Biopharm 1(5): 403–418

    Article  PubMed  CAS  Google Scholar 

  11. Egan TD (1995) Remifentanil pharmacokinetics and pharmacodynamics. A preliminary appraisal. Clin Pharmacokinet 29: 80–94

    Article  PubMed  CAS  Google Scholar 

  12. Eschenhagen T (2000) Overview of drug interactions. Combining drugs correctly! MMW Fortschr Med 142: 28–33

    CAS  Google Scholar 

  13. Flechner SM, Kolbeinsson ME, Tam J, Lum B (1989) The impact of body weight on Cyclosporine pharmacokinetics in renal transplant recipients. Transplantation 47: 806–810

    Article  PubMed  CAS  Google Scholar 

  14. Grandison MK, Boudinot FD (2000) Age related changes in protein binding of drugs: implications for therapy. Clin Pharmacokinet 38: 271–290

    Article  PubMed  CAS  Google Scholar 

  15. Green B, Duffull SB (2004) What is the best size descriptor to use for pharmacokinetic studies in the obese? Br J Clin Pharmacol 58: 119–133

    Article  PubMed  Google Scholar 

  16. Greenblatt DJ, Abernethy DR, Locniskar A, Harmatz JS, Limjuco RA, Shader RI (1984) Effect of age, gender, and obesity on midazolam kinetics. Anesthesiology 61: 27–35

    PubMed  CAS  Google Scholar 

  17. Kennedy JM, van Rij AM, Spears GF et al (2000) Polypharmacy in a general surgical unit and consequences of drug withdrawal. Br J Clin Pharmacol 49: 353–362

    Article  PubMed  CAS  Google Scholar 

  18. Kunin CM (1967) A guide to use of antibiotics in patients with renal disease. A table of recommended doses and factors governing serum levels. Ann Intern Med 67: 151–158

    PubMed  CAS  Google Scholar 

  19. Lazarou J, Pomeranz BH, Corey PN (1998) Incidence of adverse drug reactions in hospitalized patients. JAMA 279: 1200–1205

    Article  PubMed  CAS  Google Scholar 

  20. Maddox A, Horowitz M, Wishart J, Collins P (1989) Gastric and oesophageal emptying in obesity. Scand J Gastroenterol 24: 593–598

    Article  PubMed  CAS  Google Scholar 

  21. Mather LE, Björkman S (1994) Pitfalls in pharmacokinetics. Anaesth Pharmacol Rev 2: 260–270

    CAS  Google Scholar 

  22. Olkkola KT, Ahonen J (2001) Drug interactions. Curr Opin Anesth 14: 411–416

    Article  CAS  Google Scholar 

  23. Osborne R, Joel S, Slevin M (1986) Morphine intoxication in renal failure; the role of morphine-6-glucuronide. Br Med J 293: 1101

    Article  CAS  Google Scholar 

  24. Paar WD, Spengler U, Muller A, Hirner A, Sauerbruch T (1996) Diagnostik des akuten Leberversagens. Dtsch Med Wochenschr 121: 305–309

    Article  PubMed  CAS  Google Scholar 

  25. Papp-Ja´mbor C, Jaschinksi U, Forst H: Cytochrom-P450-Enzyme und ihre Bedeutung für Medikamenteninteraktionen. Anaesthesist 51: 2–15

    Google Scholar 

  26. Rowe JW, Shock NW, DeFronzo RA (1976) The influence of age on the renal response to water deprivation in man. Nephron 17: 270–278

    Article  PubMed  CAS  Google Scholar 

  27. Schuster H-P (2001) Update – Akutes Nierenversagen in der Intensivmedizin Intensivmed 38: 179–186

    Article  Google Scholar 

  28. Schwilk B, Wiedeck H, Stein B, Reinelt H, Treiber H, Bothner U (1997) Epidemiology of acute renal failure and outcome of haemodiafiltration in intensive care. Intensive Care Med 23: 1204–1211

    Article  PubMed  CAS  Google Scholar 

  29. Syberth HW. Schwab M (2007) Besonderheiten der Arzneimitteltherapie im Kindesalter. In; Pharmakotherapie Klinische Pharmakologie, 13. Aufl. Springer, Berlin Heidelberg New York

    Google Scholar 

  30. Stanski DR, Mihm FG, Rosenthal MH, Kalman SM (1983) Pharmacokinetics of high-dose thiopental used in cerebral resuscitation. Anesthesiology 53: 169–171

    Article  Google Scholar 

  31. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Magedo E, Gibney N, Tolwani A, Ronco C (2005) Beginning and ending supportive therapy for the kidney (best kidney) investigators. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294: 813–818

    Article  PubMed  CAS  Google Scholar 

  32. Wood M (1991) Pharmacokinetic drug interactions in anaesthetic practice. Clin Pharmacokinet 21: 285–307

    Article  PubMed  CAS  Google Scholar 

  33. Yee GC, Lennon TP, Gmur DJ, Cheney CL, Oeser D, Deeg HJ (1988) Effect of obesity on CSA disposition. Transplantation 45: 649–651

    Article  PubMed  CAS  Google Scholar 

  34. Zolk O, Eschenhagen T (2003) Medikamenteninteraktionen in der Antibiotika- Therapie. Notfallmedizin 29: 358–363

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik u. Poliklinik für Innere Medizin I, Universitätsklinikum Regensburg, 93042, Regensburg

    Dr. Julia Langgartner

Authors
  1. Dr. Julia Langgartner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Kiefernweg 2, 37120, Bovenden

    Hilmar Burchardi

  2. Fasanenweg 26, 66424, Homburg

    Reinhard Larsen

  3. Operative Intensivmedizin für Erwachsene, Universitätsklinikum Aachen, Pauwelsstraße 30, 52074, Aachen

    Gernot Marx

  4. Klinik für Chirurgie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck

    Elke Muhl

  5. Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main, Theodor-Stern-Kai 7, 60590, Frankfurt am Main

    Jürgen Schölmerich (Ärztlicher Direktor und Vorstandsvorsitzender) (Ärztlicher Direktor und Vorstandsvorsitzender)

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Medizin Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Langgartner, J. (2011). Pharmakodynamik und Pharmakokinetik beim Intensivpatienten, Interaktionen. In: Burchardi, H., Larsen, R., Marx, G., Muhl, E., Schölmerich, J. (eds) Die Intensivmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16929-8_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-16929-8_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-16928-1

  • Online ISBN: 978-3-642-16929-8

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation