• María I. Martínez León
  • Juan E. Gutiérrez
  • Luisa Ceres Ruiz
Part of the Learning Imaging book series (LEARN)


Wilms’ tumor (WT) is the most common intra-abdominal malignancy found in children (0.8 per 100,000 people per year). It originates from the kidney by abnormal proliferation of the metanephric blastema. The histological spectrum of this tumor ranges from elements of the renal blastema to aggressive sarcomatous variants (4–10% of WT). An association has been described between the loss of the WT1 suppressor gene found in chromosome 11 and the development of this tumor, and it may be seen in relation to WAGR syndrome (Wilms’ tumor, Aniridia, Genitourinary anomalies, and mental Retardation). Clinical presentation consists of a flank mass and hematuria, as well as hypertension, fever, and anemia.


Renal Tumor Renal Mass Clear Cell Sarcoma Malignant Rhabdoid Tumor Prune Belly Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Further Reading


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • María I. Martínez León
    • 1
  • Juan E. Gutiérrez
    • 2
  • Luisa Ceres Ruiz
    • 3
  1. 1.Radiology Department Pediatric Radiology UnitHospital Materno-Infantil del C.H.U. Carlos HayaMálagaSpain
  2. 2.Health Science CenterUniversity of TexasSan AntonioUSA
  3. 3.Radiology Department Pediatric Radiology Unit. ChiefHospital Materno-Infantil del C.H.U. Carlos HayaMálagaSpain

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