• María I. Martínez León
  • Juan E. Gutiérrez
  • Luisa Ceres Ruiz
Part of the Learning Imaging book series (LEARN)


Schizencephaly (SchC) is the most frequent neuronal migration disorder consistent in a cerebrum spinal fluid–filled cleft, lined by gray matter. The clefts may extend through the hemisphere from the ependymal lining of the lateral ventricles to the pial surface of the hemisphere. The cleft can be uni- or bilateral and are commonly located near the pre- or postcentral gyry. It develops between the third and fifth gestational months. There are two types: closed-lip SchC, characterized by gray matter-lined lips that are in contact with each other (type 1), and open-lip SchC, which has separated lips and a cleft of CSF that is lined by gray matter and extending to the underlying ventricle (type 2). Prenatal imaging allows detection and characterization of open-lip Sch; there are no reported cases prenatally diagnosed of close-lip SchC. Additional abnormalities, such as polymicrogyria, gray matter heterotopia, absence of the septum pellucidum, may also be demonstrated.


Diaphragmatic Hernia Vesicoureteral Reflux Abdominal Wall Defect Pulmonary Hypoplasia Posterior Urethral Valve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Further Reading


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • María I. Martínez León
    • 1
  • Juan E. Gutiérrez
    • 2
  • Luisa Ceres Ruiz
    • 3
  1. 1.Radiology Department Pediatric Radiology UnitHospital Materno-Infantil del C.H.U. Carlos HayaMálagaSpain
  2. 2.Health Science CenterUniversity of TexasSan AntonioUSA
  3. 3.Radiology Department Pediatric Radiology Unit. ChiefHospital Materno-Infantil del C.H.U. Carlos HayaMálagaSpain

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