Abstract
Proteoglycans that interact specifically with hyaluronan are known as the “hyalectins”. This family includes aggrecan, versican, neurocan, and brevican. These proteoglycans form macromolecular complexes with hyaluronan and contribute to the structural and mechanical stability of different tissues. The synthesis and turnover of the individual components of these complexes are highly regulated. In addition, different parts of these complexes interact with cells and influence cellular phenotype. Specific qualitative and quantitative changes take place in these macromolecules during development and disease and, in part, regulate key events that determine normal and pathological tissue phenotype. This chapter reviews both past and present evidence for the critical role that these ECM components play in the biology and pathology of human tissues.
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Acknowledgements
This chapter was prepared with grant support from the National Heart, Lung and Blood Institute of the National Institutes of Health (#18645, 5RO1HL064387 to TNW) and from the National Cancer Institute (R01 CA073839 and R01 CA082867 to BPT). The authors wish to thank Dr. Virginia M. Green for careful editing and Dr. Michael G. Kinsella for helpful discussions in the preparation of this manuscript.
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Wight, T.N., Toole, B.P., Hascall, V.C. (2011). Hyaluronan and the Aggregating Proteoglycans. In: Mecham, R. (eds) The Extracellular Matrix: an Overview. Biology of Extracellular Matrix. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16555-9_5
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