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Rapid Access to 3-(Aminomethyl)isoquinoline-Fused Polycyclic Compounds by Copper-Catalyzed Four Component Coupling, Cascade Cyclization, and Oxidation

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Copper-Catalyzed Multi-Component Reactions

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Abstract

A novel copper-catalzed synthesis of 3-(aminomethyl)isoquinoline-fused polycyclic compounds, through four-component coupling, cyclization, and oxidation, has been developed. A Mannich-type reaction with 2-ethynylbenzaldehyde, paraformaldehyde, and a secondary amine followed by treatment with a diamine component gave tricyclic isoquinolines through cascade cyclization and oxidation. Construction of fused isoquinolines of various ring sizes is also presented.

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Authors and Affiliations

  1. Graduate School of Pharmaceutical Science, Kyoto University, Yoshidashimoadachicho 26-29, Kyoto, 606-8501, Japan

    Yusuke Ohta

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  1. Yusuke Ohta
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Ohta, Y. (2011). Rapid Access to 3-(Aminomethyl)isoquinoline-Fused Polycyclic Compounds by Copper-Catalyzed Four Component Coupling, Cascade Cyclization, and Oxidation. In: Copper-Catalyzed Multi-Component Reactions. Springer Theses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-15473-7_6

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