Abstract
Resistance to drugs is a fundamental problem in the treatment of many diseases. In this work we consider the problem of drug resistance in cancer, focusing on random genetic point mutations.
A recent result obtained by Komarova is that for the case of a single drug treatment, the probability to have resistant mutants generated before the beginning of the treatment (and present, including their progeny, at some given time afterward) does not depend on the cancer turnover rate. This implies that the treatment success will not depend on such rate.
In this paper we show that the number of such resistant mutants must depend on the turnover rate, which will also be the case for the success of the treatment.
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© 2010 Springer-Verlag Berlin Heidelberg
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Tomasetti, C., Levy, D. (2010). Drug Resistance always Depends on the Turnover Rate. In: Herold, K.E., Vossoughi, J., Bentley, W.E. (eds) 26th Southern Biomedical Engineering Conference SBEC 2010, April 30 - May 2, 2010, College Park, Maryland, USA. IFMBE Proceedings, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14998-6_141
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DOI: https://doi.org/10.1007/978-3-642-14998-6_141
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-14997-9
Online ISBN: 978-3-642-14998-6
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