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Mucosal Immunity in Sexually Transmitted Infections

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Sexually Transmitted Infections and Sexually Transmitted Diseases

Abstract

Vaccines and immunotherapies for viral and chlamydial sexually transmitted infections (STIs), particularly those which are persistent and for which there is no curative therapy, are urgently needed. Progress in their rational development is limited by an incomplete understanding of the controlling immune mechanisms. Current approaches recognize that the full breadth of immune responses to these pathogens require investigation. These include humoral and cellular components of both the innate and adaptive immune responses and systemic versus local immunity. For example, in human papillomavirus (HPV) systemic IgG antibody is capable of protecting against genital infection, whereas cell-mediated immunity may play such a role in HIV-exposed but uninfected women. Furthermore, comparisons of mucosal immunity between the genitourinary (GU) and gastrointestinal (GI) tract are revealing important insights with practical consequences. This chapter discusses general aspects of mucosal immunity and how they are applied to the key viral and chlamydial STIs, HIV, herpes simplex virus (HSV), HPV, and Chlamydia trachomatis.

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Acknowledgments

Supported by: NHMRC Program Grant # 358399

NHMRC Project Grant # 632638, 408114.

The authors wish to thank Dr. Kerrie Sandgren, Dr. Stuart Turville, and Dr Margaret Stanley for providing figures and Denise Brown for clerical assistance.

Author information

Authors and Affiliations

  1. Centre for Virus Research, Westmead Millennium Institute, University of Sydney, Westmead, 412, Westmead, NSW, 2145, Australia

    Anthony L. Cunningham & Min Kim

  2. Department of Microbiology and Infectious Diseases, Royal Women’s Hospital, Department of Obstetrics and Gynecology, University of Melbourne, Murdoch Childrens Research Institute, Melbourne, Australia

    Suzanne M. Garland

  3. Centre for Virus Research, Westmead Millennium Institute, Westmead, Australia

    Heather Donaghy

Authors
  1. Anthony L. Cunningham
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  2. Suzanne M. Garland
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  3. Heather Donaghy
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  4. Min Kim
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Corresponding author

Correspondence to Anthony L. Cunningham .

Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für, Dermatologie und Venerologie, Universitätsklinikum Rostock, Strempelstraße 13-85, Rostock, 18057, Mecklenburg-Vorpomm., Germany

    Gerd E. Gross

  2. University of Texas Health Science Cente, 451 North Texas Avenue, Houston, 77598, Texas, USA

    Stephen K. Tyring

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© 2011 Springer Berlin Heidelberg

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Cunningham, A.L., Garland, S.M., Donaghy, H., Kim, M. (2011). Mucosal Immunity in Sexually Transmitted Infections. In: Gross, G., Tyring, S. (eds) Sexually Transmitted Infections and Sexually Transmitted Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14663-3_5

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  • DOI: https://doi.org/10.1007/978-3-642-14663-3_5

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  • Online ISBN: 978-3-642-14663-3

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