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HPV-Infection in HIV-Positive Men Who Have Sex with Men (MSM)

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Sexually Transmitted Infections and Sexually Transmitted Diseases

Abstract

Persistent anogenital infections with high- and low-risk HPV types are very frequent in HIV-positive men who have sex with men (MSM).

Genital warts are frequently observed in HIV-positive men.

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Abbreviations

ASCUS:

Atypical squamous cells of undetermined significance

AIN:

Anal intraepithelial neoplasia

CIN:

Cervical intraepithelial neoplasia

CRT:

Chemo-radiotherapy

5-FU:

5′-Fluorouracil

LR:

Low-risk

HAART:

Highly active antiretroviral therapy

HIV:

Human immunodeficiency virus

HPV:

Human papillomavirus

HR:

High-risk

HRA:

High resolution anoscopy

HSIL:

High-grade squamous intraepithelial lesion

IRC:

Infrared coagulation

LSIL:

Low-grade squamous intraepithelial lesion

MSM:

Men who have sex with men

PIN:

Penile intraepithelial neoplasia

SIR:

Standardized incidence ratio

TCA:

Trichloroacetic acid

References

  1. Clark, M.A., Hartley, A., Geh, J.I.: Cancer of the anal canal. Lancet Oncol. 5, 149–157 (2004)

    PubMed  Google Scholar 

  2. Munoz, N., Bosch, F.X., de Sanjose, S., et al.: Epidemiologic classification of human papillomavirus types associated with cervical cancer. N. Engl. J. Med. 348, 518–527 (2003)

    PubMed  Google Scholar 

  3. Nielson, C.M., Harris, R.B., Dunne, E.F., et al.: Risk factors for anogenital human papillomavirus infection in men. J. Infect. Dis. 196, 1137–1145 (2007)

    PubMed  Google Scholar 

  4. Schiffman, M., Castle, P.E., Jeronimo, J., et al.: Human papillomavirus and cervical cancer. Lancet 370, 890–907 (2007)

    PubMed  CAS  Google Scholar 

  5. Schiffman, M., Kjaer, S.K.: Chapter 2: Natural history of anogenital human papillomavirus infection and neoplasia. J. Natl. Cancer Inst. Monogr. 14–19 (2003)

    Google Scholar 

  6. Frisch, M., Biggar, R.J., Goedert, J.J.: Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. J. Natl. Cancer Inst. 92, 1500–1510 (2000)

    PubMed  CAS  Google Scholar 

  7. Frisch, M., Smith, E., Grulich, A., et al.: Cancer in a population-based cohort of men and women in registered homosexual partnerships. Am. J. Epidemiol. 157, 966–972 (2003)

    PubMed  Google Scholar 

  8. Grulich, A.E., van Leeuwen, M.T., Falster, M.O., et al.: Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 370, 59–67 (2007)

    PubMed  Google Scholar 

  9. Hessol, N.A., Pipkin, S., Schwarcz, S., et al.: The impact of highly active antiretroviral therapy on non-AIDS-defining cancers among adults with AIDS. Am. J. Epidemiol. 165, 1143–1153 (2007)

    PubMed  Google Scholar 

  10. Kahn, J.A., Burk, R.D.: Papillomavirus vaccines in perspective. Lancet 369, 2135–2137 (2007)

    PubMed  Google Scholar 

  11. Rogers, L.J., Eva, L.J., Luesley, D.M.: Vaccines against cervical cancer. Curr. Opin. Oncol. 20, 570–574 (2008)

    PubMed  Google Scholar 

  12. Schiller, J.T., Castellsague, X., Villa, L.L., et al.: An update of prophylactic human papillomavirus L1 virus-like particle vaccine clinical trial results. Vaccine 26(suppl 10), K53–K61 (2008)

    PubMed  CAS  Google Scholar 

  13. Garland, S.M., Hernandez-Avila, M., Wheeler, C.M., et al.: Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N. Engl. J. Med. 356, 1928–1943 (2007)

    PubMed  CAS  Google Scholar 

  14. Paavonen, J., Jenkins, D., Bosch, F.X., et al.: Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial. Lancet 369, 2161–2170 (2007)

    PubMed  CAS  Google Scholar 

  15. Hildesheim, A., Herrero, R., Wacholder, S., et al.: Effect of human papillomavirus 16/18 L1 viruslike particle vaccine among young women with preexisting infection: a randomized trial. JAMA 298, 743–753 (2007)

    PubMed  CAS  Google Scholar 

  16. Giuliano, A., Palefsky, J., group obotmqHvets: The efficacy of quadrivalent HPV (types 6/11/16/18) vaccine in reducing the incidence of HPV infection and HPV-related genital disease in young men. Eurogin2008 Nice, France. Abstract SS 19–17 (2008)

    Google Scholar 

  17. Palefsky, J., Giuliano, A., group obotmqHvets (2008) Efficacy of the quadrivalent HPV vaccine against HPV 6/11/16/18-related genital infection in young men. Eurogin2008 Nice, France. Abstract TC 2-11

    Google Scholar 

  18. Kiviat, N.B., Critchlow, C.W., Holmes, K.K., et al.: Association of anal dysplasia and human papillomavirus with immunosuppression and HIV infection among homosexual men. AIDS 7, 43–49 (1993)

    PubMed  CAS  Google Scholar 

  19. Kreuter, A., Brockmeyer, N.H., Hochdorfer, B., et al.: Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection. J. Am. Acad. Dermatol. 52, 603–608 (2005)

    PubMed  Google Scholar 

  20. Nyitray, A., Nielson, C.M., Harris, R.B., et al.: Prevalence of and risk factors for anal human papillomavirus infection in heterosexual men. J. Infect. Dis. 197, 1676–1684 (2008)

    PubMed  Google Scholar 

  21. Palefsky, J.M., Holly, E.A., Efirdc, J.T., et al.: Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with men. AIDS 19, 1407–1414 (2005)

    PubMed  Google Scholar 

  22. Palefsky, J.M., Holly, E.A., Ralston, M.L., et al.: Prevalence and risk factors for human papillomavirus infection of the anal canal in human immunodeficiency virus (HIV)-positive and HIV-negative homosexual men. J. Infect. Dis. 177, ­361–367 (1998)

    PubMed  CAS  Google Scholar 

  23. Lacey, H.B., Wilson, G.E., Tilston, P., et al.: A study of anal intraepithelial neoplasia in HIV positive homosexual men. Sex. Transm. Infect. 75, 172–177 (1999)

    PubMed  CAS  Google Scholar 

  24. Fox, P.A.: Human papillomavirus and anal intraepithelial neoplasia. Curr. Opin. Infect. Dis. 19, 62–66 (2006)

    PubMed  Google Scholar 

  25. Palefsky, J.: Human papillomavirus and anal neoplasia. Curr. HIV/AIDS Rep. 5, 78–85 (2008)

    PubMed  Google Scholar 

  26. Palefsky, J.M., Holly, E.A., Ralston, M.L., et al.: High incidence of anal high-grade squamous intra-epithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men. AIDS 12, 495–503 (1998)

    PubMed  CAS  Google Scholar 

  27. McCloskey, J.C., Metcalf, C., French, M.A., et al.: The frequency of high-grade intraepithelial neoplasia in anal/perianal warts is higher than previously recognized. Int. J. STD AIDS 18, 538–542 (2007)

    PubMed  CAS  Google Scholar 

  28. IARC: IARC monographs on the evaluation of carcinogenic risks to humans - Human Papillomaviruses. International Agency for Research on Cancer (IARC) Lyon, France (2007)

    Google Scholar 

  29. zur Hausen, H.: Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer 2, 342–350 (2002)

    PubMed  CAS  Google Scholar 

  30. Palefsky, J.M., Holly, E.A., Ralston, M.L., et al.: Anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual and bisexual men: prevalence and risk factors. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 17, 320–326 (1998)

    PubMed  CAS  Google Scholar 

  31. Abramowitz, L., Benabderrahmane, D., Ravaud, P., et al.: Anal squamous intraepithelial lesions and condyloma in HIV-infected heterosexual men, homosexual men and women: prevalence and associated factors. AIDS 21, ­1457–1465 (2007)

    PubMed  Google Scholar 

  32. Cranston, R.D., Hart, S.D., Gornbein, J.A., et al.: The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men. Int. J. STD AIDS 18, 77–80 (2007)

    PubMed  CAS  Google Scholar 

  33. Kreuter, A., Brockmeyer, N.H., Weissenborn, S.J., et al.: Penile intraepithelial neoplasia is frequent in HIV-positive men with anal dysplasia. J. Invest. Dermatol. 128, ­2316–2324 (2008)

    PubMed  CAS  Google Scholar 

  34. Pereira, A., Lacerda, H.R., Barros, R.R.: Prevalence and factors associated with anal lesions mediated by human papillomavirus in men with HIV/AIDS. Int. J. STD AIDS 19, 192–196 (2008)

    PubMed  CAS  Google Scholar 

  35. Piketty, C., Darragh, T.M., Heard, I., et al.: High prevalence of anal squamous intraepithelial lesions in HIV-positive men despite the use of highly active antiretroviral therapy. Sex. Transm. Dis. 31, 96–99 (2004)

    PubMed  Google Scholar 

  36. Critchlow, C.W., Surawicz, C.M., Holmes, K.K., et al.: Prospective study of high grade anal squamous intraepithelial neoplasia in a cohort of homosexual men: influence of HIV infection, immunosuppression and human papillomavirus infection. AIDS 9, 1255–1262 (1995)

    PubMed  CAS  Google Scholar 

  37. Durante, A.J., Williams, A.B., Da Costa, M., et al.: Incidence of anal cytological abnormalities in a cohort of human immunodeficiency virus-infected women. Cancer Epidemiol. Biomarkers Prev. 12, 638–642 (2003)

    PubMed  Google Scholar 

  38. Etienney, I., Vuong, S., Daniel, F., et al.: Prevalence of anal cytologic abnormalities in a French referral population: a prospective study with special emphasis on HIV, HPV, and smoking. Dis. Colon Rectum 51, 67–72 (2008)

    PubMed  Google Scholar 

  39. Palefsky, J.M., Holly, E.A., Ralston, M.L., et al.: Effect of highly active antiretroviral therapy on the natural history of anal squamous intraepithelial lesions and anal human papillomavirus infection. J. Acquir. Immune Defic. Syndr. 28, 422–428 (2001)

    PubMed  CAS  Google Scholar 

  40. Bower, M., Powles, T., Newsom-Davis, T., et al.: HIV-associated anal cancer: has highly active antiretroviral therapy reduced the incidence or improved the outcome? J. Acquir. Immune Defic. Syndr. 37, 1563–1565 (2004)

    PubMed  Google Scholar 

  41. Diamond, C., Taylor, T.H., Aboumrad, T., et al.: Increased incidence of squamous cell anal cancer among men with AIDS in the era of highly active antiretroviral therapy. Sex. Transm. Dis. 32, 314–320 (2005)

    PubMed  Google Scholar 

  42. Clifford, G.M., Polesel, J., Rickenbach, M., et al.: Cancer risk in the Swiss HIV Cohort Study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy. J. Natl. Cancer Inst. 97, 425–432 (2005)

    PubMed  Google Scholar 

  43. Patel, P., Hanson, D.L., Sullivan, P.S., et al.: Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992–2003. Ann. Intern. Med. 148, 728–736 (2008)

    PubMed  Google Scholar 

  44. D’Souza, G., Wiley, D.J., Li, X., et al.: Incidence and epidemiology of anal cancer in the multicenter AIDS cohort study. J. Acquir. Immune Defic. Syndr. 48, 491–499 (2008)

    PubMed  Google Scholar 

  45. Piketty, C., Selinger-Leneman, H., Grabar, S., et al.: Marked increase in the incidence of invasive anal cancer among HIV-infected patients despite treatment with combination antiretroviral therapy. AIDS 22, 1203–1211 (2008)

    PubMed  Google Scholar 

  46. Chiao, E.Y., Giordano, T.P., Richardson, P., et al.: Human immunodeficiency virus-associated squamous cell cancer of the anus: epidemiology and outcomes in the highly active antiretroviral therapy era. J. Clin. Oncol. 26, 474–479 (2008)

    PubMed  Google Scholar 

  47. Abbasakoor, F., Boulos, P.B.: Anal intraepithelial neoplasia. Br. J. Surg. 92, 277–290 (2005)

    PubMed  CAS  Google Scholar 

  48. Barrasso, R., Gross, G.: External genitalia: diagnosis. In: Gross G, Barrasso R (eds.) Human Papilloma Virus Infection – A Clinical Atlas, pp. 291–361. Ullstein Mosby Berlin/Wiesbaden, Germany (1997)

    Google Scholar 

  49. Chin-Hong, P.V., Palefsky, J.M.: Natural history and clinical management of anal human papillomavirus disease in men and women infected with human immunodeficiency virus. Clin. Infect. Dis. 35, 1127–1134 (2002)

    PubMed  Google Scholar 

  50. Goldie, S.J., Kuntz, K.M., Weinstein, M.C., et al.: Cost-effectiveness of screening for anal squamous intraepithelial lesions and anal cancer in human immunodeficiency virus-negative homosexual and bisexual men. Am. J. Med. 108, 634–641 (2000)

    PubMed  CAS  Google Scholar 

  51. Goldie, S.J., Kuntz, K.M., Weinstein, M.C., et al.: The clinical effectiveness and cost-effectiveness of screening for anal squamous intraepithelial lesions in homosexual and bisexual HIV-positive men. JAMA 281, 1822–1829 (1999)

    PubMed  CAS  Google Scholar 

  52. Chiao, E.Y., Giordano, T.P., Palefsky, J.M., et al.: Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review. Clin. Infect. Dis. 43, 223–233 (2006)

    PubMed  Google Scholar 

  53. Garcia, F.U., Haber, M.M., Butcher, J., et al.: Increased sensitivity of anal cytology in evaluation of internal compared with external lesions. Acta Cytol. 51, 893–899 (2007)

    PubMed  Google Scholar 

  54. Crothers, B.A.: The Bethesda System 2001: update on terminology and application. Clin. Obstet. Gynecol. 48, 98–107 (2005)

    PubMed  Google Scholar 

  55. Chin-Hong, P.V., Berry, J.M., Cheng, S.C., et al.: Comparison of patient- and clinician-collected anal ­cytology samples to screen for human papillomavirus-associated anal ­intraepithelial neoplasia in men who have sex with men. Ann. Intern. Med. 149, 300–306 (2008)

    PubMed  Google Scholar 

  56. Kreuter, A., Brockmeyer, N.H., Altmeyer, P., et al.: Anal intraepithelial neoplasia in HIV infection. J. Dtsch Dermatol. Ges. 6, 925–934 (2008)

    PubMed  Google Scholar 

  57. Berry, J.M., Palefsky, J.M., Welton, M.L.: Anal cancer and its precursors in HIV-positive patients: perspectives and management. Surg. Oncol. Clin. N. Am. 13, 355–373 (2004)

    PubMed  Google Scholar 

  58. Watson, A.J., Smith, B.B., Whitehead, M.R., et al.: Malignant progression of anal intra-epithelial neoplasia. ANZ J. Surg. 76, 715–717 (2006)

    PubMed  Google Scholar 

  59. Fenger, C., Nielsen, V.T.: Precancerous changes in the anal canal epithelium in resection specimens. Acta Pathol. Microbiol. Immunol. Scand. [A] 94, 63–69 (1986)

    CAS  Google Scholar 

  60. Klaes, R., Friedrich, T., Spitkovsky, D., et al.: Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int. J. Cancer 92, 276–284 (2001)

    PubMed  CAS  Google Scholar 

  61. Bernard, J.E., Butler, M.O., Sandweiss, L., et al.: Anal intraepithelial neoplasia: correlation of grade with p16INK4a immunohistochemistry and HPV in situ hybridization. Appl. Immunohistochem. Mol. Morphol. 16, 215–220 (2008)

    PubMed  CAS  Google Scholar 

  62. Kreuter, A., Wieland, U., Gambichler, T., et al.: p16ink4a expression decreases during imiquimod treatment of anal intraepithelial neoplasia in human immunodeficiency virus-infected men and correlates with the decline of lesional high-risk human papillomavirus DNA load. Br. J. Dermatol. 157, 523–530 (2007)

    PubMed  CAS  Google Scholar 

  63. Walts, A.E., Lechago, J., Bose, S.: P16 and Ki67 immunostaining is a useful adjunct in the assessment of biopsies for HPV-associated anal intraepithelial neoplasia. Am. J. Surg. Pathol. 30, 795–801 (2006)

    PubMed  Google Scholar 

  64. Darvishian, F., Stier, E.A., Soslow, R.A., et al.: Immunoreactivity of p16 in anal cytology specimens: histologic correlation. Cancer 108, 66–71 (2006)

    PubMed  Google Scholar 

  65. Gross, G., Tyring, S., von Krogh, G., et al.: External genitalia: treatment. In: Gross G, Barrasso R (eds.) Human Papilloma Virus Infection – A Clinical Atlas, pp. 365–376. Ullstein Mosby, Berlin/Wiesbaden (1997)

    Google Scholar 

  66. Mayeaux Jr., E.J., Dunton, C.: Modern management of external genital warts. J. Low. Genit. Tract Dis. 12, 185–192 (2008)

    PubMed  Google Scholar 

  67. Kreuter, A., Wieland, U.: Human papillomavirus-associated diseases in HIV-infected men who have sex with men. Curr. Opin. Infect. Dis. 22(2), 109–114 (2009)

    PubMed  Google Scholar 

  68. Pineda, C.E., Berry, J.M., Jay, N., et al.: High-resolution anoscopy targeted surgical destruction of anal high-grade squamous intraepithelial lesions: a ten-year experience. Dis. Colon Rectum 51, 829–835 (2008). discussion 835–827

    PubMed  Google Scholar 

  69. Nathan, M., Hickey, N., Mayuranathan, L., et al.: Treatment of anal human papillomavirus-associated disease: a long term outcome study. Int. J. STD AIDS 19, 445–449 (2008)

    PubMed  CAS  Google Scholar 

  70. Goldstone, S.E., Hundert, J.S., Huyett, J.W.: Infrared coagulator ablation of high-grade anal squamous intraepithelial lesions in HIV-negative males who have sex with males. Dis. Colon Rectum 50, 565–575 (2007)

    PubMed  Google Scholar 

  71. Goldstone, S.E., Kawalek, A.Z., Huyett, J.W.: Infrared coagulator: a useful tool for treating anal squamous intraepithelial lesions. Dis. Colon Rectum 48, 1042–1054 (2005)

    PubMed  Google Scholar 

  72. Wieland, U., Brockmeyer, N.H., Weissenborn, S.J., et al.: Imiquimod treatment of anal intraepithelial neoplasia in HIV-positive men. Arch. Dermatol. 142, 1438–1444 (2006)

    PubMed  CAS  Google Scholar 

  73. Cranston, R.D., Hirschowitz, S.L., Cortina, G., et al.: A retrospective clinical study of the treatment of high-grade anal dysplasia by infrared coagulation in a population of HIV-positive men who have sex with men. Int. J. STD AIDS 19, 118–120 (2008)

    PubMed  CAS  Google Scholar 

  74. Stier, E.A., Goldstone, S.E., Berry, J.M., et al.: Infrared coagulator treatment of high-grade anal dysplasia in HIV-infected individuals: an AIDS malignancy consortium pilot study. J. Acquir. Immune Defic. Syndr. 47, 56–61 (2008)

    PubMed  Google Scholar 

  75. Kreuter, A., Potthoff, A., Brockmeyer, N.H., et al.: Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV-infected men. J. Invest. Dermatol. 128, 2078–2083 (2008)

    PubMed  CAS  Google Scholar 

  76. Klencke, B., Matijevic, M., Urban, R.G., et al.: Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: a Phase I study of ZYC101. Clin. Cancer Res. 8, 1028–1037 (2002)

    PubMed  CAS  Google Scholar 

  77. Palefsky, J.M., Berry, J.M., Jay, N., et al.: A trial of SGN-00101 (HspE7) to treat high-grade anal intraepithelial neoplasia in HIV-positive individuals. AIDS 20, 1151–1155 (2006)

    PubMed  CAS  Google Scholar 

  78. Ajani, J.A., Winter, K.A., Gunderson, L.L., et al.: Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA 299, 1914–1921 (2008)

    PubMed  CAS  Google Scholar 

  79. Blazy, A., Hennequin, C., Gornet, J.M., et al.: Anal carcinomas in HIV-positive patients: high-dose chemoradiotherapy is feasible in the era of highly active antiretroviral therapy. Dis. Colon Rectum 48, 1176–1181 (2005)

    PubMed  Google Scholar 

  80. Kauh, J., Koshy, M., Gunthel, C., et al.: Management of anal cancer in the HIV-positive population. Oncology (Williston Park) 19, 1634–1638 (2005). discussion 1638–1640, 1645 passim

    Google Scholar 

  81. Palefsky, J.M.: HPV infection in men. Dis. Markers 23, 261–272 (2007)

    PubMed  Google Scholar 

  82. Oehler-Janne, C., Huguet, F., Provencher, S., et al.: HIV-specific differences in outcome of squamous cell carcinoma of the anal canal: a multicentric cohort study of HIV-pos­itive patients receiving highly active antiretroviral therapy. J. Clin. Oncol. 26, 2550–2557 (2008)

    PubMed  Google Scholar 

  83. Wexler, A., Berson, A.M., Goldstone, S.E., et al.: Invasive anal squamous-cell carcinoma in the HIV-positive patient: outcome in the era of highly active antiretroviral therapy. Dis. Colon Rectum 51, 73–81 (2008)

    PubMed  Google Scholar 

  84. Salama, J.K., Mell, L.K., Schomas, D.A., et al.: Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: a multicenter experience. J. Clin. Oncol. 25, 4581–4586 (2007)

    PubMed  CAS  Google Scholar 

  85. Giuliano, A.R., Lazcano, E., Villa, L.L., et al.: Circumcision and sexual behavior: factors independently associated with human papillomavirus detection among men in the HIM study. Int. J. Cancer 124, 1251–1257 (2009)

    PubMed  CAS  Google Scholar 

  86. Giuliano, A.R., Lazcano-Ponce, E., Villa, L.L., et al.: The human papillomavirus infection in men study: human papillomavirus prevalence and type distribution among men residing in Brazil, Mexico, and the United States. Cancer Epidemiol. Biomarkers Prev. 17, 2036–2043 (2008)

    PubMed  CAS  Google Scholar 

  87. Giuliano, A.R., Lu, B., Nielson, C.M., et al.: Age-specific prevalence, incidence, and duration of human papillomavirus infections in a cohort of 290 US men. J. Infect. Dis. 198, 827–835 (2008)

    PubMed  Google Scholar 

  88. Sirera, G., Videla, S., Pinol, M., et al.: High prevalence of human papillomavirus infection in the anus, penis and mouth in HIV-positive men. AIDS 20, 1201–1204 (2006)

    PubMed  Google Scholar 

  89. van der Snoek, E.M., Niesters, H.G., Mulder, P.G., et al.: Human papillomavirus infection in men who have sex with men participating in a Dutch gay-cohort study. Sex. Transm. Dis. 30, 639–644 (2003)

    PubMed  Google Scholar 

  90. Giovannelli, L., Migliore, M.C., Capra, G., et al.: Penile, urethral, and seminal sampling for diagnosis of human papillomavirus infection in men. J. Clin. Microbiol. 45, 248–251 (2007)

    PubMed  Google Scholar 

  91. Weaver, B.A., Feng, Q., Holmes, K.K., et al.: Evaluation of genital sites and sampling techniques for detection of human papillomavirus DNA in men. J. Infect. Dis. 189, 677–685 (2004)

    PubMed  CAS  Google Scholar 

  92. Dillner, J., von Krogh, G., Horenblas, S., et al.: Etiology of squamous cell carcinoma of the penis. Scand. J. Urol. Nephrol. 205(suppl), 189–193 (2000)

    Google Scholar 

  93. Gomousa-Michael, M., Gialama, E., Gomousas, N., et al.: Genital human papillomavirus infection and associated penile intraepithelial neoplasia in males infected with the human immunodeficiency virus. Acta Cytol. 44, 305–309 (2000)

    PubMed  CAS  Google Scholar 

  94. Gross, G., Pfister, H.: Role of human papillomavirus in penile cancer, penile intraepithelial squamous cell neoplasias and in genital warts. Med. Microbiol. Immunol. 193, 35–44 (2004)

    PubMed  CAS  Google Scholar 

  95. Porter, W.M., Francis, N., Hawkins, D., et al.: Penile intraepithelial neoplasia: clinical spectrum and treatment of 35 cases. Br. J. Dermatol. 147, 1159–1165 (2002)

    PubMed  CAS  Google Scholar 

  96. Backes, D.M., Kurman, R.J., Pimenta, J.M., et al.: Systematic review of human papillomavirus prevalence in invasive penile cancer. Cancer Causes Control 100, 405–407 (2008)

    Google Scholar 

  97. Rubin, M.A., Kleter, B., Zhou, M., et al.: Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesis. Am. J. Pathol. 159, 1211–1218 (2001)

    PubMed  CAS  Google Scholar 

  98. Heideman, D.A., Waterboer, T., Pawlita, M., et al.: Human papillomavirus-16 is the predominant type etiologically involved in penile squamous cell carcinoma. J. Clin. Oncol. 25, 4550–4556 (2007)

    PubMed  Google Scholar 

  99. Madsen, B.S., van den Brule, A.J., Jensen, H.L., et al.: Risk factors for squamous cell carcinoma of the penis–population-based case-control study in Denmark. Cancer Epidemiol. Biomarkers Prev. 17, 2683–2691 (2008)

    PubMed  CAS  Google Scholar 

  100. Engels, E.A., Pfeiffer, R.M., Goedert, J.J., et al.: Trends in cancer risk among people with AIDS in the United States 1980–2002. AIDS 20, 1645–1654 (2006)

    PubMed  Google Scholar 

  101. de Lima Rocha, M.G., Faria, F.L., Souza Mdo, C., et al.: Detection of human papillomavirus infection in penile samples through liquid-based cytology and polymerase chain reaction. Cancer 114, 489–493 (2008)

    PubMed  Google Scholar 

  102. Cardamakis, E., Kotoulas, I.G., Relakis, K., et al.: Peoscopic diagnosis of flat condyloma and penile intraepithelial neoplasia. Clinical manifestation. Gynecol. Obstet. Invest. 43, 255–260 (1997)

    PubMed  CAS  Google Scholar 

  103. Nicolau, S.M., Martins, N.V., Ferraz, P.E., et al.: Importance of peniscopy, oncologic cytology and histopathology in the diagnosis of penile infection by human papillomavirus. São Paulo Med. J. 115, 1330–1335 (1997)

    PubMed  CAS  Google Scholar 

  104. Aboulafia, D.M., Gibbons, R.: Penile cancer and human papilloma virus (HPV) in a human immunodeficiency virus (HIV)-infected patient. Cancer Invest. 19, 266–272 (2001)

    PubMed  CAS  Google Scholar 

  105. Theodore, C., Androulakis, N., Spatz, A., et al.: An explosive course of squamous cell penile cancer in an AIDS patient. Ann. Oncol. 13, 475–479 (2002)

    PubMed  CAS  Google Scholar 

  106. Markos, A.R.: The management of penile intraepithelial neoplasia in genitourinary medicine. Int. J. STD AIDS 14, 314–319 (2003)

    PubMed  CAS  Google Scholar 

  107. Micali, G., Nasca, M.R., Innocenzi, D., et al.: Penile cancer. J. Am. Acad. Dermatol. 54, 369–391 (2006). quiz 391–364

    PubMed  Google Scholar 

  108. Cameron, J.E., Mercante, D., O’Brien, M., et al.: The impact of highly active antiretroviral therapy and immunodeficiency on human papillomavirus infection of the oral cavity of human immunodeficiency virus-seropositive adults. Sex. Transm. Dis. 32, 703–709 (2005)

    PubMed  Google Scholar 

  109. Coutlee, F., Trottier, A.M., Ghattas, G., et al.: Risk factors for oral human papillomavirus in adults infected and not infected with human immunodeficiency virus. Sex. Transm. Dis. 24, 23–31 (1997)

    PubMed  CAS  Google Scholar 

  110. D’Souza, G., Fakhry, C., Sugar, E.A., et al.: Six-month natural history of oral versus cervical human papillomavirus infection. Int. J. Cancer 121, 143–150 (2007)

    PubMed  Google Scholar 

  111. Fakhry, C., D’Souza, G., Sugar, E., et al.: Relationship between prevalent oral and cervical human papillomavirus infections in human immunodeficiency virus-positive and -negative women. J. Clin. Microbiol. 44, 4479–4485 (2006)

    PubMed  Google Scholar 

  112. Kreimer, A.R., Alberg, A.J., Daniel, R., et al.: Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus. J. Infect. Dis. 189, 686–698 (2004)

    PubMed  Google Scholar 

  113. Marais, D.J., Passmore, J.A., Denny, L., et al.: Cervical and oral human papillomavirus types in HIV-1 positive and negative women with cervical disease in South Africa. J. Med. Virol. 80, 953–959 (2008)

    PubMed  Google Scholar 

  114. Hagensee, M.E., Cameron, J.E., Leigh, J.E., et al.: Human papillomavirus infection and disease in HIV-infected individuals. Am. J. Med. Sci. 328, 57–63 (2004)

    PubMed  Google Scholar 

  115. Kreuter, A., Brockmeyer, N.H., Altmeyer, P., et al.: Rapid onset of multifocal human papillomavirus 72-associated oral intraepithelial neoplasia in a human immunodeficiency virus-infected patient. Br. J. Dermatol. 157, 826–828 (2007)

    PubMed  CAS  Google Scholar 

  116. Chaturvedi, A.K., Engels, E.A., Anderson, W.F., et al.: Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J. Clin. Oncol. 26, 612–619 (2008)

    PubMed  Google Scholar 

  117. Ryerson, A.B., Peters, E.S., Coughlin, S.S., et al.: Burden of potentially human papillomavirus-associated cancers of the oropharynx and oral cavity in the US, 1998–2003. Cancer 113, 2901–2909 (2008)

    PubMed  Google Scholar 

  118. Cameron, J.E., Hagensee, M.E.: Oral HPV complications in HIV-infected patients. Curr. HIV/AIDS Rep. 5, 126–131 (2008)

    PubMed  Google Scholar 

  119. Greenspan, D., Canchola, A.J., MacPhail, L.A., et al.: Effect of highly active antiretroviral therapy on frequency of oral warts. Lancet 357, 1411–1412 (2001)

    PubMed  CAS  Google Scholar 

  120. King, M.D., Reznik, D.A., O’Daniels, C.M., et al.: Human papillomavirus-associated oral warts among human immunodeficiency virus-seropositive patients in the era of highly active antiretroviral therapy: an emerging infection. Clin. Infect. Dis. 34, 641–648 (2002)

    PubMed  Google Scholar 

  121. Leigh, J.: Oral warts rise dramatically with use of new agents in HIV. HIV Clin. 12, 7 (2000)

    PubMed  CAS  Google Scholar 

  122. Ramirez-Amador, V., Esquivel-Pedraza, L., Sierra-Madero, J., et al.: The changing clinical spectrum of human immunodeficiency virus (HIV)-related oral lesions in 1, 000 consecutive patients: a 12-year study in a referral center in Mexico. Medicine (Baltimore) 82, 39–50 (2003)

    Google Scholar 

  123. Greenspan, D., de Villiers, E.M., Greenspan, J.S., et al.: Unusual HPV types in oral warts in association with HIV infection. J. Oral Pathol. 17, 482–488 (1988)

    PubMed  CAS  Google Scholar 

  124. Volter, C., He, Y., Delius, H., et al.: Novel HPV types present in oral papillomatous lesions from patients with HIV infection. Int. J. Cancer 66, 453–456 (1996)

    PubMed  CAS  Google Scholar 

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Wieland, U., Kreuter, A., Pfister, H. (2011). HPV-Infection in HIV-Positive Men Who Have Sex with Men (MSM). In: Gross, G., Tyring, S. (eds) Sexually Transmitted Infections and Sexually Transmitted Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14663-3_38

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