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Prothesenregister und Langzeitergebnisse

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AE-Manual der Endoprothetik

Zusammenfassung

Die endoprothetische Versorgung im Bereich der Hüftgelenks- und Kniegelenkschirurgie ist ein weit verbreitetes Standardverfahren. Bei einer Reihe von Erkrankungen lassen sich so Beschwerden wie Schmerzen und Bewegungseinschränkungen effektiv behandeln. Im Erfassungsjahr 2008 wurden in der externen vergleichenden Qualitätssicherung unter anderem 156.887 Hüftgelenk-TEP-Primärimplantationen und 98.870 hüftgelenksnahe Frakturen, die überwiegend operativ, d. h. entweder endoprothetisch oder osteosynthetisch behandelt worden waren, bei der Bundesgeschäftsstelle Qualitätssicherung (BQS) analysiert. In keinem anderen europäischen Land werden somit mehr Hüftendoprothesen implantiert als in Deutschland. Da einerseits die erfolgreiche Methode der Endoprothetik auch bei immer jüngeren betroffenen Patienten angewandt wird und andererseits die Bevölkerung immer weiter altert, steigen auch die Ansprüche an die Funktionszeit einer implantierten Endoprothese. Die Zahl der gemeldeten Wechseloperationen (Revisionen) im Erfassungsjahr 2008 betrug 22.631 Fälle. Da Wechseloperationen mit einer erheblich höheren Morbidität (5,0 vs. 13,8 %) und Letalität (0,2 vs. 1,3 %) einhergehen, sind diese möglichst zu vermeiden (http://www.bqs-online.com).

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Literatur

  • Akhavan S, Matthiesen MM, Schulte L, Penoyar T, Kraay MJ, Rimnac CM, Goldberg VM (2006) Clinical and histologic results related to a low-modulus composite total hip replacement stem. J Bone Joint Surg Am 88-A:1308–1314

    Article  Google Scholar 

  • Arthursson AJ, Furnes O, Espehaug B, Havelin LI, Soreide JA (2007) Prosthesis survival after total hip arthroplasty – does surgical approach matter? Analysis of 19,304 Charnley and 6,002 exeter primary total hip arthroplasties reported to the Norwegian arthroplasty register. Acta Orthop 78:719–729

    Article  PubMed  Google Scholar 

  • Ballard WT, Callaghan JJ, Sullivan PM, Johnston RC (1994) The results of improved cementing techniques for total hip arthroplasty in patients less than fifty years old. A ten-year follow-up study. J Bone Joint Surg Am 76:959–964

    PubMed  CAS  Google Scholar 

  • Bhattacharyya T, Chang D, Meigs JB, Estok DM, Malchau H (2007) Mortality after periprosthetic fracture of the femur. J Bone Joint Surg Am 89:2658–2662

    Article  PubMed  Google Scholar 

  • Breusch S, Heisel C, Muller J, Borchers T, Mau H (2002) Influence of cement viscosity on cement interdigitation and venous fat content under in vivo conditions: a bilateral study of 13 sheep. Acta Orthop Scand 73:409–415

    Article  PubMed  Google Scholar 

  • Bystrom S, Espehaug B, Furnes O, Havelin LI (2003) Femoral head size is a risk factor for total hip luxation: a study of 42,987 primary hip arthroplasties from the Norwegian arthroplasty register. Acta Orthop Scand 74:514–524

    Article  PubMed  Google Scholar 

  • Chandler HP, Reineck FT, Wixson RL, McCarthy JC (1981) Total hip replacement in patients younger than thirty years old. A five-year follow-up study. J Bone Joint Surg Am 63:1426–1434

    PubMed  CAS  Google Scholar 

  • Charnley J (1960) Anchorage of the femoral head prosthesis to the shaft of the femur. J Bone Joint Surg Br 42-B:28–30

    PubMed  CAS  Google Scholar 

  • Christiansen T (1974) A combined endo- and total hip prosthesis with trunnion-bearing. The Christiansen prosthesis. Acta Chir Scand 140:185–188

    PubMed  CAS  Google Scholar 

  • Clarke MT, Lee PTH, Roberts CP, Gray J, Keene GS, Rusthon N (2004) Contamination of primary total hip replacements in standard and ultra-clean operating theaters detected by the polymerase chain reaction. Acta Orthop Scand 75:544–548

    Article  PubMed  Google Scholar 

  • Colville J, Raunio P (1978) Charnley low-friction arthroplasties of the hip in rheumatoid arthritis. A study of the complications and results of 378 arthroplasties. J Bone Joint Surg Br 60-B:498–503

    PubMed  CAS  Google Scholar 

  • D’Antonio JA, Capello WN, Manley MT, Feinberg J (1997) Hydroxyapatite coated implants. Total hip arthroplasty in the young patient and patients with avascular necrosis. Clin Orthop Relat Res 344:124–138

    Article  PubMed  Google Scholar 

  • Davis N, Curry A, Gambhir AK, Panigrahi H, Walker CR, Wilkins EGL, Worsley MA, Kay PR (1999) Intraoperative bacterial contamination in operations for joint replacement. J Bone Joint Surg Br 81:886–889

    Article  PubMed  CAS  Google Scholar 

  • Digas G (2005) New polymer materials in total hip arthroplasty. Evaluation with radiostereometry, bone densitometry, radiography and clinical parameters. Acta Orthop Suppl 76:3–82

    PubMed  Google Scholar 

  • Digas G, Thanner J, Nivbrant B, Rohrl S, Strom H, Karrholm J (2003) Increase in early polyethylene wear after sterilization with ethylene oxide: radiostereometric analyses of 201 total hips. Acta Orthop Scand 74:531–541

    Article  PubMed  Google Scholar 

  • Digas G, Karrholm J, Thanner J, Malchau H, Herberts P (2004) The Otto Aufranc award. Highly cross-linked polyethylene in total hip arthroplasty: randomized evaluation of penetration rate in cemented and uncemented sockets using radiostereometric analysis. Clin Orthop Relat Res 429:6–16

    Article  PubMed  Google Scholar 

  • Effenberger H (2007) Hüftendoprothetik – Konstruktion, Klassifikation, Implantate, Ergebnisse. http: //www.implantat-atlas.com/pdf/hueftendoprothetik.pdf

    Google Scholar 

  • Engesaeter LB, Lie SA, Espehaug B, Furnes O, Vollset SE, Havelin LI (2003) Antibiotic prophylaxis in total hip arthroplasty: effects of antibiotic prophylaxis systemically and in bone cement on the revision rate of 22,170 primary hip replacements followed 0–14 years in the Norwegian arthroplasty register. Acta Orthop Scand 74:644–651

    Article  PubMed  Google Scholar 

  • Engesaeter LB, Espehaug B, Lie SA, Furnes O, Havelin LI (2006) Does cement increase the risk of infection in primary total hip arthroplasty? Revision rates in 56,275 cemented and uncemented primary THAs followed for 0–16 years in the Norwegian arthroplasty register. Acta Orthop 77:351–358

    Article  PubMed  Google Scholar 

  • Engh CA, Griffin WL, Marx CL (1990) Cementless acetabular components. J Bone Joint Surg Br 72:53–59

    PubMed  CAS  Google Scholar 

  • Eskelinen A, Paavolainen P, Helenius I, Pulkkinen P, Remes V (2006) Total hip arthroplasty for rheumatoid arthritis in younger patients: 2,557 replacements in the Finnish arthroplasty register followed for 0–24 years. Acta Orthop 77:853–865

    Article  PubMed  Google Scholar 

  • Espehaug B, Havelin LI, Engesaeter LB, Langeland N, Vollset SE (1997) Patient-related risk factors for early revision of total hip replacements. A population register-based case-control study of 674 revised hips. Acta Orthop Scand 68:207–215

    Article  PubMed  CAS  Google Scholar 

  • Espehaug B, Havelin LI, Engesaeter LB, Vollset SE (1999) The effect of hospital-type and operating volume on the survival of hip replacements. A review of 39,505 primary total hip replacements reported to the Norwegian arthroplasty register, 1988–1996. Acta Orthop Scand 70:12–18

    Article  PubMed  CAS  Google Scholar 

  • Espehaug B, Furnes O, Havelin LI, Engesaeter LB, Vollset SE, Kindseth O (2006) Registration completeness in the Norwegian arthroplasty register. Acta Orthop 77:49–56

    Article  PubMed  Google Scholar 

  • Finnish Arthroplasty Register (2008) The 2006 implant yearbook on orthopedic endoprostheses – Finnish arthroplasty register. National Agency for Medicines, Helsinki

    Google Scholar 

  • Flugsrud GB, Nordsletten L, Espehaug B, Havelin LI, Meyer HE (2007) The effect of middle-age body weight and physical activity on the risk of early revision hip arthroplasty: a cohort study of 1,535 individuals. Acta Orthop 78:99–107

    Article  PubMed  Google Scholar 

  • Furnes O, Lie SA, Espehaug B, Vollset SE, Engesaeter LB, Havelin LI (2001) Hip disease and the prognosis of total hip replacements. A review of 53,698 primary total hip replacements reported to the Norwegian arthroplasty register 1987–99. J Bone Joint Surg Br 83:579–586

    Article  PubMed  CAS  Google Scholar 

  • Furnes O, Havelin LI, Espehaug B, Fenstad AM, Steindal K (2005) Report 2005. The Norwegian arthroplasty register, Bergen

    Google Scholar 

  • Furnes O, Havelin LI, Espehaug B, Steindal K, Soras TE (2008). Report 2008. The Norwegian arthroplasty register, Bergen

    Google Scholar 

  • Giannikas KA, Din R, Sadiq S, Dunningham TH (2002) Medium-term results of the ABG total hip arthroplasty in young patients. J Arthroplast 17:184–188

    Article  Google Scholar 

  • Gjertsen JE, Lie SA, Fevang JM, Havelin LI, Engesaeter LB, Vinje T, Furnes O (2007) Total hip replacement after femoral neck fractures in elderly patients: results of 8,577 fractures reported to the Norwegian Arthroplasty Register. Acta Orthop 78:491–497

    Article  PubMed  Google Scholar 

  • Goosen JHM, Castelein RM, Runne WC, Dartee DA, Verheyen CCPM (2006) Long-term results of a soft interface- (proplast-)coated femoral stem. Acta Orthop 77:585–590

    Article  PubMed  Google Scholar 

  • Harris WH, McGann WA (1986) Loosening of the femoral component after use of the medullary-plug cementing technique. Follow-up note with a minimum five-year follow-up. J Bone Joint Surg Am 68:1064–1066

    PubMed  CAS  Google Scholar 

  • Havelin LI, Gjerdet NR, Lunde OD, Rait M, Sudmann E (1986) Wear of the Christiansen hip prosthesis. Acta Orthop Scand 57:419–422

    Article  PubMed  CAS  Google Scholar 

  • Havelin LI, Espehaug B, Vollset SE, Engesaeter LB (1995) The effect of the type of cement on early revision of Charnley total hip prostheses. A review of eight thousand five hundred and seventy-nine primary arthroplasties from the Norwegian Arthroplasty Register. J Bone Joint Surg Am 77:1543–1550

    PubMed  CAS  Google Scholar 

  • Herberts P, Malchau H (1997) How outcome studies have changed total hip arthroplasty practices in Sweden. Clin Orthop Relat Res 344:44–60

    Article  PubMed  Google Scholar 

  • Herberts P, Malchau H (2000) Long-term registration has improved the quality of hip replacement: a review of the Swedish THR register comparing 160,000 cases. Acta Orthop Scand 71:111–121

    Article  PubMed  CAS  Google Scholar 

  • Johnsen SP, Sorensen HT, Lucht U, Soballe K, Overgaard S, Pedersen AB (2006) Patient-related predictors of implant failure after primary total hip replacement in the initial, short- and long-terms – a nationwide Danish follow-up study including 36,984 patients. J Bone Joint Surg Br 88-B:1303–1308

    Article  Google Scholar 

  • Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457–481

    Article  Google Scholar 

  • Karrholm J, Garellick G, Herberts P (2006) Annual report 2005. Swedish hip arthroplasty register, Gothenburg

    Google Scholar 

  • Karrholm J, Garellick G, Herberts P (2007) Annual Report 2006. Swedish hip arthroplasty register, Gothenburg

    Google Scholar 

  • Karrholm J, Garellick G, Rogmark C, Herberts P (2008) Annual report 2007. Swedish hip arthroplasty register, Gothenburg

    Google Scholar 

  • Keisu KS, Orozco F, McCallum JD, III, Bissett G, Hozack WJ, Sharkey PF, Rothman RH (2001) Cementless femoral fixation in the rheumatoid patient undergoing total hip arthroplasty: minimum 5-year results. J Arthroplast 16:415–421

    Article  CAS  Google Scholar 

  • Kienapfel H, Koller M, Wust A, Sprey C, Merte H, Engenhart-Cabillic R, Griss P (1999) Prevention of heterotopic bone formation after total hip arthroplasty: a prospective randomised study comparing postoperative radiation therapy with indomethacin medication. Arch Orthop Trauma Surg 119:296–302

    Article  PubMed  CAS  Google Scholar 

  • Kienapfel H, Niethard FU, Langendorff HU, Gabel M, Güttler T, Willmann G, Lang I (2003) Externe Qualitätssicherung Chirurgie und Orthopädie, 1.Treffen der Fach- und Arbeitsgruppen Bund/Land 30./31.10.2003– Deutsches Endoprothesenregister e. V. 2003. Münster

    Google Scholar 

  • Kleimann KH, Markefka B, Holfelder G (1996) Zusammenfassung der Potentialentwicklung für Hüft- und Kniegelenkoperationen in Allgemeinkrankenhäusern der Bundesrepublik Deutschland. Orthopädie 5:445–448

    Google Scholar 

  • Kreutzer J, Schneider M, Schlegel U, Ewerbeck V, Breusch SJ (2005) Cemented total hip arthroplasty in Germany – an update. Z Orthop Ihre Grenzgeb 143:48–55

    Article  PubMed  CAS  Google Scholar 

  • Lachiewicz PF, McCaskill B, Inglis A, Ranawat CS, Rosenstein BD (1986) Total hip arthroplasty in juvenile rheumatoid arthritis. Two to eleven-year results. J Bone Joint Surg Am 68:502–508

    PubMed  CAS  Google Scholar 

  • Lehtimaki MY, Lehto MU, Kautiainen H, Savolainen HA, Hamalainen MM (1997) Survivorship of the Charnley total hip arthroplasty in juvenile chronic arthritis. A follow-up of 186 cases for 22 years. J Bone Joint Surg Br 79:792–795

    Article  PubMed  CAS  Google Scholar 

  • Lehtimaki MY, Kautiainen H, Lehto UK, Hamalainen MM (1999) Charnley low-friction arthroplasty in rheumatoid patients: a survival study up to 20 years. J Arthroplast 14:657–661

    Article  CAS  Google Scholar 

  • Lindahl H, Garellick G, Regner H, Herberts P, Malchau H (2006) Three hundred and twenty-one periprosthetic femoral fractures. J Bone Joint Surg Am 88:1215–1222

    Article  PubMed  Google Scholar 

  • Lindahl H, Oden A, Garellick G, Malchau H (2007) The excess mortality due to periprosthetic femur fracture. A study from the Swedish national hip arthroplasty register. Bone 40:1294–1298

    Article  PubMed  CAS  Google Scholar 

  • Lucht U (2000) The Danish hip arthroplasty register. Acta Orthop Scand 71:433–439

    Article  PubMed  CAS  Google Scholar 

  • Lyback CC, Lyback CO, Kyro A, Kautiainen HJ, Belt EA (2004) Survival of bi-metric femoral stems in 77 total hip arthroplasties for juvenile chronic arthritis. Int Orthop 28:357–361

    Article  PubMed  CAS  Google Scholar 

  • Maathuis PGM, Neut D, Busscher HJ, Mei HC van der, Horn JR van (2005) Perioperative contamination in primary total hip arthroplasty. Clin Orthop 433:136–139

    PubMed  Google Scholar 

  • Malchau H, Herberts P, Eisler T, Garellick G, Soderman P (2002) The Swedish total hip replacement register. J Bone Joint Surg Am 84-A(Suppl 2):2–20

    PubMed  Google Scholar 

  • Malchau H, Garellick G, Eisler T, Karrholm J, Herberts P (2005) Presidential guest address: the Swedish hip registry: increasing the sensitivity by patient outcome data. Clin Orthop Relat Res 441:19–29

    Article  PubMed  Google Scholar 

  • Maloney WJ, Jasty M, Rosenberg A, Harris WH (1990) Bone lysis in well-fixed cemented femoral components. J Bone Joint Surg Br 72:966–970

    PubMed  CAS  Google Scholar 

  • Mau H, Schelling K, Heisel C, Wang JS, Breusch SJ (2004) Comparison of various vacuum mixing systems and bone cements as regards reliability, porosity and bending strength. Acta Orthop Scand 75:160–172

    Article  PubMed  Google Scholar 

  • McLaughlin GM, Lee KR (2006) The outcome of total hip replacement in obese and non-obese patients at 10- to 18-years. J Bone Joint Surg Br 88-B:1286–1292

    Article  Google Scholar 

  • Morscher EW (1983) Cementless total hip arthroplasty. Clin Orthop Relat Res 181:76–91

    PubMed  Google Scholar 

  • Morshed S, Bozic KJ, Ries MD, Malchau H, Colford JM Jr (2007) Comparison of cemented and uncemented fixation in total hip replacement: a meta-analysis. Acta Orthop 78:315–326

    Article  PubMed  Google Scholar 

  • Münger P, Röder C, Ackermann-Liebrich U, Busato A (2006) Patient-related risk factors leading to aseptic stem loosening in total hip arthroplasty – A case-control study of 5,035 patients. Acta Orthop 77:567–574

    Article  PubMed  Google Scholar 

  • Nevalainen J, Hirvonen A, Pulkkinen P (2000) Appendix: a study of the outcome of arthroplasty surgery in Finland, commissioned by the Ministry of Social Affairs and Health. The 1998 implant yearbook on orthopaedic endoprotheses. National Agency for Medicines, Helsinki

    Google Scholar 

  • Nixon M, Taylor G, Sheldon P, Iqbal SJ, Harper W (2007) Does bone quality predict loosening of cemented total hip replacements? J Bone Joint Surg Br 89:1303–1308

    Article  PubMed  CAS  Google Scholar 

  • Pitto RP, Lang I, Kienapfel H, Willert HG (2002) The German arthroplasty register. Acta Orthop Scand Suppl 73:30–33

    Article  PubMed  CAS  Google Scholar 

  • Porsch M, Siegel A (1998) Artificial hip replacement in young patients with hip dysplasia – long-term outcome after 10 years. Z Orthop Ihre Grenzgeb 136:548–553

    Article  PubMed  CAS  Google Scholar 

  • Poss R, Maloney JP, Ewald FC, Thomas WH, Batte NJ, Hartness C, Sledge CB (1984) Six- to 11-year results of total hip arthroplasty in rheumatoid arthritis. Clin Orthop Relat Res 182:109–116

    PubMed  Google Scholar 

  • Puolakka TJ, Pajamaki KJ, Halonen PJ, Pulkkinen PO, Paavolainen P, Nevalainen JK (2001) The Finnish arthroplasty register: report of the hip register. Acta Orthop Scand 72:433–441

    Article  PubMed  CAS  Google Scholar 

  • Ranawat CS, Dorr LD, Inglis AE (1980) Total hip arthroplasty in protrusio acetabuli of rheumatoid arthritis. J Bone Joint Surg Am 62:1059–1065

    PubMed  CAS  Google Scholar 

  • Roder C, El Kerdi A, Frigg A, Kolling C, Staub LP, Bach B, Muller U (2005) The Swiss orthopaedic registry. Bull Hosp Jt Dis 63:15–19

    PubMed  Google Scholar 

  • Saito S, Saito M, Nishina T, Ohzono K, Ono K (1989) Long-term results of total hip arthroplasty for osteonecrosis of the femoral head. A comparison with osteoarthritis. Clin Orthop Relat Res 244:198–207

    PubMed  Google Scholar 

  • Schlegel UJ, Sturm M, Ewerbeck V, Breusch SJ (2004) Efficacy of vacuum bone cement mixing systems in reducing methylmethacrylate fume exposure: comparison of 7 different mixing devices and handmixing. Acta Orthop Scand 75:559–566

    Article  PubMed  Google Scholar 

  • Schmalzried TP, Jasty M, Harris WH (1992) Periprosthetic bone loss in total hip arthroplasty. Polyethylene wear debris and the concept of the effective joint space. J Bone Joint Surg Am 74:849–863

    CAS  Google Scholar 

  • Schneider W, Knahr K (2004) Total hip replacement in younger patients: survival rate after avascular necrosis of the femoral head. Acta Orthop Scand 75:142–146

    Article  PubMed  Google Scholar 

  • Simank HG, Brocai DR, Reiser D, Thomsen M, Sabo D, Lukoschek M (1997) Middle-term results of threaded acetabular cups. High failure rates five years after surgery. J Bone Joint Surg Br 79:366–370

    Article  PubMed  CAS  Google Scholar 

  • Smabrekke A, Espehaug B, Havelin LI, Furnes O (2004) Operating time and survival of primary total hip replacements: an analysis of 31,745 primary cemented and uncemented total hip replacements from local hospitals reported to the Norwegian arthroplasty register 1987–2001. Acta Orthop Scand 75:524–532

    Article  PubMed  Google Scholar 

  • Sochart DH, Porter ML (1997) The long-term results of Charnley low-friction arthroplasty in young patients who have congenital dislocation, degenerative osteoarthrosis, or rheumatoid arthritis. J Bone Joint Surg Am 79:1599–1617

    PubMed  CAS  Google Scholar 

  • Soderman P, Malchau H, Herberts P, Johnell O (2000) Are the findings in the Swedish national total hip arthroplasty register valid? A comparison between the Swedish national total hip arthroplasty register, the national discharge register, and the national death register. J Arthroplast 15:884–889

    Article  CAS  Google Scholar 

  • Thanner J, Freij-Larsson C, Karrholm J, Malchau H, Wesslen B (1995) Evaluation of Boneloc. Chemical and mechanical properties, and a randomized clinical study of 30 total hip arthroplasties. Acta Orthop Scand 66:207–214

    Article  PubMed  CAS  Google Scholar 

  • Wilson-MacDonald J, Morscher E, Masar Z (1990) Cementless uncoated polyethylen acetabular components in total hip replacement – review of five- to 10-years results. J Bone Joint Surg Br 72-B:423–430

    Google Scholar 

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Authors and Affiliations

  1. Klinik für Spezielle Orthopädische Chirurgie und Unfallchirurgie, Auguste-Viktoria-Klinikum, Rubensstraße 125, 12157, Berlin, Deutschland

    Prof. Dr. Heino Kienapfel & Dr. med. Andreas Becker

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  1. Prof. Dr. Heino Kienapfel
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  2. Dr. med. Andreas Becker
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Correspondence to Heino Kienapfel .

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Editors and Affiliations

  1. Forschung und Biomechanik, Universität Ulm / Inst. für Unfallchir., Helmholtzstraße 14, Ulm, 89081, Germany

    Lutz Claes

  2. St. Vinzenz- und Elisabeth-Hospital, Katholisches Klinikum Mainz, An der Goldgrube 11, Mainz, 55131, Germany

    Peter Kirschner

  3. Campus Charité Mitte (CCM), Centrum f. Muskuloskeletale Chirurgie, Charitéplatz 1, Berlin, 10117, Germany

    Carsten Perka

  4. Orthopädische Klinik, König Ludwig Haus, Universität Würzburg, Brettreichstraße 11, Würzburg, 97074, Germany

    Maximilian Rudert

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Kienapfel, H., Becker, A. (2012). Prothesenregister und Langzeitergebnisse. In: Claes, L., Kirschner, P., Perka, C., Rudert, M. (eds) AE-Manual der Endoprothetik. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14646-6_13

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