Homeostatic Chemokines, Cytokines and Their Receptors in Peripheral Lymphoid Organ Development

  • Péter Balogh


The tissue structure of secondary lymphoid organs is characterized by a highly compartmentalized distribution of its haematopoietic and stromal cells. The ordered arrangement of mobile lymphoid cells is assisted by the sessile stromal tissue constituents, whose cytokine production provides survival stimuli for lymphocytes as well as positioning cues within the various lymphocyte compartments. In this part, the developmental aspects of essential cytokines and homeostatic chemokines that also profoundly affect the embryonic formation of secondary lymphoid tissues are presented. Importantly, the same soluble factors may operate during the initiation as well as the maintenance of organized lymphoid structure, although the interacting haemopoietic and stromal cellular partners are substantially different between the two conditions. This part describes the main soluble factors and their combined effects on the development of peripheral lymphoid tissues.


Secondary Lymphoid Organ Secondary Lymphoid Tissue Mature Lymphocyte Peripheral Lymphoid Organ Lymphoid Neogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Berlin Heidelberg 2011

Authors and Affiliations

  • Péter Balogh
    • 1
  1. 1.Department of Immunology and Biotechnology, Faculty of MedicineUniversity of PécsPécsHungary

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