Homeostatic Chemokines, Cytokines and Their Receptors in Peripheral Lymphoid Organ Development
The tissue structure of secondary lymphoid organs is characterized by a highly compartmentalized distribution of its haematopoietic and stromal cells. The ordered arrangement of mobile lymphoid cells is assisted by the sessile stromal tissue constituents, whose cytokine production provides survival stimuli for lymphocytes as well as positioning cues within the various lymphocyte compartments. In this part, the developmental aspects of essential cytokines and homeostatic chemokines that also profoundly affect the embryonic formation of secondary lymphoid tissues are presented. Importantly, the same soluble factors may operate during the initiation as well as the maintenance of organized lymphoid structure, although the interacting haemopoietic and stromal cellular partners are substantially different between the two conditions. This part describes the main soluble factors and their combined effects on the development of peripheral lymphoid tissues.
KeywordsSecondary Lymphoid Organ Secondary Lymphoid Tissue Mature Lymphocyte Peripheral Lymphoid Organ Lymphoid Neogenesis
- Cupedo T, Lund FE, Ngo VN, Randall TD, Jansen W, Greuter MJ, de Waal-Malefyt R, Kraal G, Cyster JG, Mebius RE (2004) Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13. J Immunol 173:4889–4896PubMedGoogle Scholar
- Fujimoto M, Naka T, Nakagawa R, Kawazoe Y, Morita Y, Tateishi A, Okumura K, Narazaki M, Kishimoto T (2000) Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice. J Immunol 165:1799–1806PubMedGoogle Scholar
- Ozawa T, Koyama K, Ando T, Ohnuma Y, Hatsushika K, Ohba T, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A (2007) Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors/nuclear factor-kappaB pathway and interferon-gamma/dexamethasone. Mod Rheumatol 17:459–463CrossRefPubMedGoogle Scholar