NF-κB Signalling and Lymphoid Tissue Organogenesis
The development of secondary lymphoid organs is initiated by crosstalk interactions between bone marrow-derived cells and stromal cells. Several of the molecules mediating this cell–cell communication are members of the Tumour Necrosis Factor (TNF) family of ligands and receptors that induce changes in the gene expression program through activation of different members of the Nuclear Factor kappa B (NF-кB) family of transcription factors. Engagement of TNF receptors by their specific ligands results in the activation of the canonical and non-canonical NF-кB pathways that ultimately induce the expression of cytokines, chemokines and cell adhesion molecules required for lymphorganogenesis, organization of specific areas in these organs and their long-term maintenance. Analysis of transgenic mice with impairments in these pathways have underlined the important function of different NF-кB family members, their cell specificity and requirement during lymphoid tissue organogenesis and helped to define some of their transcriptional targets.
KeywordsGene Expression Program Secondary Lymphoid Organ Marginal Sinus Lymphoid Tissue Inducer Lymphoid Tissue Inducer Cell
This work was supported by a BBSRC project grant and a EU FP7 INFLACARE Collaborative Project grant to J. Caamaño and Deutsche Forschungsgemeinschaft (WE-2224/2, WE 2224/4, and WE-2224/5) grants to F. Weih.
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