Lymphotoxin/Tumour Necrosis Factor Family Members as Morphogenic Factors

  • Péter Balogh


Initially described as potent soluble mediators involved in inflammation, Tumour Necrosis Factor (TNF) and lymphotoxin alpha and beta (LTα/β) are now also appreciated as cardinal morphogenic regulators in secondary lymphoid organ formation, in addition to related activities of other members of the same TNF/LT family. Their developmental effects simultaneously show both substantial overlaps and remarkable tissue-specific differences. This part details the receptor–ligand relationship and developmental roles of those members of this large group of soluble or membrane-bound cytokines that have been associated with secondary lymphoid organ formation.


Tumour Necrosis Factor Lymphoid Organ Tumour Necrosis Factor Receptor Tumour Necrosis Factor Family Peripheral Lymphoid Organ 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Berlin Heidelberg 2011

Authors and Affiliations

  • Péter Balogh
    • 1
  1. 1.Department of Immunology and Biotechnology, Faculty of MedicineUniversity of PécsPécsHungary

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