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Adipocyte–Brain: Crosstalk

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Sensory and Metabolic Control of Energy Balance

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 52))

Abstract

The initial discovery of leptin, an appetite-suppressing hormone originating from fat tissue, substantially supported the idea that fat-borne factors act on the brain to regulate food intake and energy expenditure. Since then, a growing number of cytokines have been found to be released from adipose tissue, thus acting in an endocrine manner. These adipocytokines include not only, e.g., adiponectin, apelin, resistin, and visfatin, but also inflammatory cytokines and steroid hormones such as estrogens and glucocorticoids. They are secreted from their adipose depots and differ in terms of release stimuli, downstream signaling, and their action on the brain. Clearly, adipocytokines play a prominent role in the central control of body weight, and the deregulation of this circuit may lead to the development of obesity and related disorders. In this chapter, we will focus on crosstalk mechanisms and the deregulation of adipocytokines at the expression level and/or sites of central action that eventually will lead to the development and perpetuation of obesity and diabetes.

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Authors and Affiliations

  1. Department of Internal Medicine I, Luebeck University, Ratzeburger Allee 160, 23538, Luebeck, Germany

    Carla Schulz, Kerstin Paulus & Hendrik Lehnert

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  1. Carla Schulz
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  2. Kerstin Paulus
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  3. Hendrik Lehnert
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Correspondence to Hendrik Lehnert .

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  1. Potsdam-Rehbrücke (DIFE), Abt. Molekulare Genetik, Deutsches Institut für Ernährungsforschu, Arthur-Scheunert-Allee 114-116, Nuthetal, 14558, Brandenburg, Germany

    Wolfgang Meyerhof

  2. Martinistr. 52, Hamburg, 20246, Germany

    Ulrike Beisiegel

  3. German Institute of Human Nutrition Pots, Arthur-Scheunert-Allee 114-116, Nuthetal, 14558, Germany

    Hans-Georg Joost

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Schulz, C., Paulus, K., Lehnert, H. (2011). Adipocyte–Brain: Crosstalk. In: Meyerhof, W., Beisiegel, U., Joost, HG. (eds) Sensory and Metabolic Control of Energy Balance. Results and Problems in Cell Differentiation, vol 52. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14426-4_16

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