Comparing a New Volumetric Breast Density Method (VolparaTM) to Cumulus

  • Mona Jeffreys
  • Jennifer Harvey
  • Ralph Highnam
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6136)

Abstract

Computer-aided thresholding programs, such as Cumulus, are seen as the gold standard for breast density measurement. In this paper we compare a new volumetric breast density software package, VolparaTM to an expert’s BI-RADS visual assessment and Cumulus and show that all are closely related, whilst there is a less close relationship between Cumulus percent breast density and absolute volume of dense tissue. These results support the further validation of this new method against breast cancer outcomes.

Keywords

Breast density volumetric Volpara 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Byng, J.W., Boyd, N.F., Fishell, E., Jong, R.A., Yaffe, M.J.: The quantitative analysis of mammographic densities. Phys. Med. Biol. 39, 1629–1638 (1994)CrossRefGoogle Scholar
  2. 2.
    McCormack, V., dos Santos Silva, I.: Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 15, 1159–1169 (2006)CrossRefGoogle Scholar
  3. 3.
    Prevrhal, S., Shepherd, J., Smith-Bindman, R., Cummings, S., Kerlikowske, K.: Accuracy of Mammographic Breast Density Analysis: Results of Formal Operator Training. Cancer Epidemiol. Biomarkers Prev. 11, 1389–1393 (2002)Google Scholar
  4. 4.
    Martin, K.E., Helvie, M.A., Zhou, C., Roubidoux, M.A., Bailey, J.E., Paramagul, C., Blane, C.E., Klein, K.A., Sonnad, S.S., Chan, H.P.: Mammographic density measured with quantitative computer-aided method: comparison with radiologists’ estimates and BI-RADS categories. Radiology 240, 656–665 (2006)CrossRefGoogle Scholar
  5. 5.
    Highnam, R., Brady, M.: Mammographic Image Analysis. Kluwer Academic Publishers, Dortrecht (1999)MATHGoogle Scholar
  6. 6.
    Highnam, R., Pan, X., Warren, R., Jeffreys, M., Davey Smith, G., Brady, M.: Breast composition measurements using retrospective standard mammogram form (SMF). Phys. Med. Biol. 51, 2695–2713 (2006)CrossRefGoogle Scholar
  7. 7.
    Highnam, R., Brady, M., Yaffe, M., Karssemeijer, N., Harvey, J.: Robust Breast Composition Measurements - Volpara. In: IWDM Proceedings (in press, 2010)Google Scholar
  8. 8.
    Pisano, E., Gatsonis, C., Yaffe, M., Hendrick, R., Tosteson, A., Fryback, D., Bassett, L., Baum, J., Conant, E., Jong, R., Rebner, M., D’Orsi, C.: American College of Radiology Imaging Network digital mammographic imaging screening trial: objectives and methodology. Radiology 236, 404–412 (2005)CrossRefGoogle Scholar
  9. 9.
    Harvey, J.A.: Quantitative assessment of percent breast density: analog versus digital acquisition. Technol. Cancer Res. Treat. 3, 611–616 (2004)MathSciNetGoogle Scholar
  10. 10.
    Jeffreys, M., Warren, R., Highnam, R., Davey Smith, G.: Initial experiences of using an automated volumetric measure of breast density: the standard mammogram form. Br. J. Radiol. 79, 378–382 (2006)CrossRefGoogle Scholar
  11. 11.
    Aitken, Z., McCormack, V.A., Highnam, R.P., Martin, L., Gunasekara, A., Melnichouk, O., Mawdsley, G., Peressotti, C., Yaffe, M., Boyd, N.F., Dos Santos, S.I.: Screen-film mammographic density and breast cancer risk: a comparison of the volumetric standard mammogram form and the interactive threshold measurement methods. Cancer Epidemiol. Biomarkers Prev. 19, 418–428 (2010)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Mona Jeffreys
    • 1
  • Jennifer Harvey
    • 2
  • Ralph Highnam
    • 3
  1. 1.Department of Social MedicineUniversity of BristolBristolUK
  2. 2.Department of RadiologyUniversity of Virginia Health SystemCharlottesvilleUS
  3. 3.Matakina Technology LimitedWellington

Personalised recommendations