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Poly(n-butylcyanoacrylate) Submicron Particles Loaded with Ciprofloxacin for Potential Treatment of Bacterial Infections

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Book cover Trends in Colloid and Interface Science XXIII

Part of the book series: Progress in Colloid and Polymer Science ((PROGCOLLOID,volume 137))

Abstract

Poly(n-butylcyanoacrylate) submicron colloidal particles loaded with the antibiotic ciprofloxacin are prepared by emulsion polymerization and characterized by scanning electron microscopy, dynamic light scattering, nuclear magnetic resonance and gel-permeation chromatography. The entrapment efficiency for ciprofloxacin in the polymer particles is investigated as a function of the monomer and drug concentrations in the polymerization medium. The kinetics of ciprofloxacin release from the polymer particles is found to depend on the pH of the release medium. Studies by gel-permeation chromatography indicate for a possible drug-polymer association. The antibacterial activity of the obtained formulation is tested on a clinical isolate of Escherichia coli bacterium and is found to be similar to that of the free drug.

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Acknowledgements

G.Y. and C.D. are thankful to COST Action D43 of the European Community.

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Authors and Affiliations

  1. Laboratory of Nanoparticle Science and Technology, Department of General and Inorganic Chemistry, Faculty of Chemistry, Sofia University ‘St.Kliment Ohridski’, 1 “James Bourchier” Blvd., 1164, Sofia, Bulgaria

    Georgi Yordanov & Ceco Dushkin

  2. Microbiological Laboratory, Multiprofile Hospital for Active Treatment ‘Dr. Nikola Vasiliev’, 1 “17-th January” Sqr., 2500, Kyustendil, Bulgaria

    Nikola Abrashev

Authors
  1. Georgi Yordanov
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  2. Nikola Abrashev
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  3. Ceco Dushkin
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Correspondence to Georgi Yordanov .

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Yordanov, G., Abrashev, N., Dushkin, C. (2010). Poly(n-butylcyanoacrylate) Submicron Particles Loaded with Ciprofloxacin for Potential Treatment of Bacterial Infections. In: Trends in Colloid and Interface Science XXIII. Progress in Colloid and Polymer Science, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13461-6_11

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