Skip to main content
SpringerLink
Log in

Mehrlinge

  • Chapter
Die Geburtshilfe

  • 7517 Accesses

Zusammenfassung

Die Zahl der Mehrlingsgeburten ist weiter steigend. Dieser Trend wird auf die zunehmende Anwendung der Methoden der assistierten Reproduktion und das steigende Lebensalter der Gebärenden zurückgeführt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Literatur

  • American College of Obstetricians and Gynecologists (ACOG) (1999) ACOG educational bulletin. Special problems of multiple gestation. Number 253, November 1998 (replaces No 131, August 1989) Int J Gynaecol Obstet 64 (3): 323–333

    Google Scholar 

  • Asrat T (2001) Intra-amniotic infection in patients with preterm prelabor rupture of membranes. Pathophysiology, detection, and management. Clin Perinatol 28 (4): 735–751

    Article  CAS  PubMed  Google Scholar 

  • Baldwin VJ (1994) Anomalous development of twins. Pathology of multiple pregnancy. Springer, Berlin Heidelberg New York, pp 169–197

    Book  Google Scholar 

  • Barigye O, Pasquini L et al. (2005) High risk of unexpected late fetal death in monochorionic twins despite intensive ultrasound surveillance: a cohort study. PLoS Med 2 (6): e172

    Article  PubMed Central  PubMed  Google Scholar 

  • Beasley E Megerian G et al. (1999) Monoamniotic twins: case series and proposal for antenatal management. Obstet Gynecol 93 (1): 130–134

    Article  PubMed  Google Scholar 

  • Benachi A, Pons JC (1998) Is the route of delivery a meaningful issue in twins? Clin Obstet Gynecol 41 (1): 30–35

    Article  CAS  PubMed  Google Scholar 

  • Benirschke K, des Roches Harper V (1977) The acardiac anomaly. Teratology 15 (3): 311–316

    Article  CAS  PubMed  Google Scholar 

  • Benirschke K, Kim CK (1973) Multiple pregnancy. 1. N Engl J Med 288 (24): 1276–84

    Article  CAS  PubMed  Google Scholar 

  • Berghella V (2009) Novel developments on cervical length screening and progesterone for preventing preterm birth. Br J Obstet Gynaecol 116 (2): 182–187

    Article  CAS  Google Scholar 

  • Berghella V, Ness A et al. (2005) Cervical sonography in women with symptoms of preterm labor. Obstet Gynecol Clin North Am 32 (3): 383–96

    Article  PubMed  Google Scholar 

  • Bieber FR, Nance WE et al. (1981) Genetic studies of an acardiac monster: evidence of polar body twinning in man. Science 213 (4509): 775–777

    Article  CAS  PubMed  Google Scholar 

  • Blickstein I, Arabin B et al. (2007) The Istanbul international consensus statement on the perinatal care of multiple pregnancy. J Perinat Med 35 (6): 465–467

    PubMed  Google Scholar 

  • Boggess KA, Chisholm CA (1997) Delivery of the nonvertex second twin: a review of the literature. Obstet Gynecol Surv 52 (12): 728–735

    Article  CAS  PubMed  Google Scholar 

  • Caritis SN, Rouse DJ et al. (2009) Prevention of preterm birth in triplets using 17 alpha-hydroxyprogesterone caproate: a randomized controlled trial. Obstet Gynecol 113(2 Pt 1): 285–292

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Cirigliano VP, Canadas P et al. (2003) Rapid prenatal diagnosis of aneuploidies and zygosity in multiple pregnancies by amniocentesis with single insertion of the needle and quantitative fluorescent PCR. Prenat Diagn 23 (8): 629–633

    Article  CAS  PubMed  Google Scholar 

  • Cleary-Goldman J, D’Alton ME (2005) Uncomplicated monochorionic diamniotic twins and the timing of delivery. PLoS Med 2 (6): e180

    Article  PubMed Central  PubMed  Google Scholar 

  • Cousins LM, Smok DP et al. (2005) AmniSure placental alpha microglobulin- 1 rapid immunoassay versus standard diagnostic methods for detection of rupture of membranes. Am J Perinatol 22 (6): 317–320

    Article  PubMed  Google Scholar 

  • Cox M, Murphy K et al. (1992) Spontaneous cessation of umbilical blood flow in the acardiac fetus of a twin pregnancy. Prenat Diagn 12 (8): 689–693

    Article  CAS  PubMed  Google Scholar 

  • Cutting R, Morroll D et al. (2008) Elective single embryo transfer: guidelines for practice British Fertility Society and Association of Clinical Embryologists. Hum Fertil (Camb) 11 (3): 131–146

    Article  Google Scholar 

  • DeFalco LM, Sciscione AC et al. (2006) Inpatient versus outpatient management of monoamniotic twins and outcomes. Am J Perinatol 23 (4): 205–211

    Article  PubMed  Google Scholar 

  • Derom R, Orlebeke J et al. (1995) The epidemiology of multiple births in Europe. In: Keith LG, Papiernik E, Keith DM, Luke B Multiple pregnancy. Parthenon, Lancaster, pp 145–162

    Google Scholar 

  • Derom R, Vlietinck R et al. (1991) Perinatal mortality in the East Flanders Prospective Twin Survey (preliminary results) Eur J Obstet Gynecol Reprod Biol 41 (1): 25–26

    Article  CAS  PubMed  Google Scholar 

  • Durand-Reville M, Schumacker-Blay C et al. (2005) Monochorial monoamniotic twin pregnancies: targeted surveillance reduces the risks of cord entanglement. Eur J Obstet Gynecol Reprod Biol 119 (1): 130–131

    Article  PubMed  Google Scholar 

  • Evans MI, Britt DW (2008) Fetal reduction 2008. Curr Opin Obstet Gynecol 20 (4): 386–393

    Article  PubMed  Google Scholar 

  • Evans MI, Dommergues M et al. (1996) International, collaborative experience of 1789 patients having multifetal pregnancy reduction: a plateauing of risks and outcomes. J Soc Gynecol Investig 3 (1): 23–26

    Article  CAS  PubMed  Google Scholar 

  • Ezra Y, Shveiky D et al. (2005) Intensive management and early delivery reduce antenatal mortality in monoamniotic twin pregnancies. Acta Obstet Gynecol Scand 84 (5): 432–435

    Article  PubMed  Google Scholar 

  • Fisk NM, Ware M et al. (1996) Molecular genetic etiology of twin reversed arterial perfusion sequence. Am J Obstet Gynecol 174 (3): 891–4

    Article  CAS  PubMed  Google Scholar 

  • Fonseca EB, Celik E et al. (2007) Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med 357 (5): 462–469

    Article  CAS  PubMed  Google Scholar 

  • Garite TJ, Clark RH et al. (2004) Twins and triplets: the effect of plurality and growth on neonatal outcome compared with singleton infants. Am J Obstet Gynecol 191 (3): 700–707

    Article  PubMed  Google Scholar 

  • Gibson JY, D’Cruz CA et al. (1986) Acardiac anomaly: review of the subject with case report and emphasis on practical sonography. J Clin Ultrasound 14 (7): 541–545

    Article  CAS  PubMed  Google Scholar 

  • Gomez R, Romero R et al. (2005) Cervicovaginal fibronectin improves the prediction of preterm delivery based on sonographic cervical length in patients with preterm uterine contractions and intact membranes. Am J Obstet Gynecol 192 (2): 350–359

    Article  CAS  PubMed  Google Scholar 

  • Gratacos E, Lewi L et al. (2007) A classification system for selective intrauterine growth restriction in monochorionic pregnancies according to umbilical artery Doppler flow in the smaller twin. Ultrasound Obstet Gynecol 30 (1): 28–34

    Article  CAS  PubMed  Google Scholar 

  • Hack KE, Derks JB et al. (2008) Increased perinatal mortality and morbidity in monochorionic versus dichorionic twin pregnancies: clinical implications of a large Dutch cohort study. Br J Obstet Gynaecol 115 (1): 58–67

    Article  CAS  Google Scholar 

  • Hannelius U, Gherman L et al. (2007) Large-scale zygosity testing using single nucleotide polymorphisms. Twin Res Hum Genet 10 (4): 604–625

    Article  PubMed  Google Scholar 

  • Hartley RS, Emanuel I et al. (2001) Perinatal mortality and neonatal morbidity rates among twin pairs at different gestational ages: optimal delivery timing at 37 to 38 weeks’ gestation. Am J Obstet Gynecol 184 (3): 451–458

    Article  CAS  PubMed  Google Scholar 

  • Hecher K, Hackeloer BJ et al. (1997) Umbilical cord coagulation by operative microendoscopy at 16 weeks’ gestation in an acardiac twin. Ultrasound Obstet Gynecol 10 (2): 130–132

    Article  CAS  PubMed  Google Scholar 

  • Heyborne KD, Porreco RP et al. (2005) Improved perinatal survival of monoamniotic twins with intensive inpatient monitoring. Am J Obstet Gynecol 192 (1): 96–101

    Article  PubMed  Google Scholar 

  • Hirtenlehner K, Huber A et al. (2003) Reduction of preeclampsia in multiple pregnancies by a dedicated monitoring protocol. J Soc Gynecol Investig 10 (7): 418–422

    Article  PubMed  Google Scholar 

  • Hogle KL, Hutton EK et al. (2003) Cesarean delivery for twins: a systematic review and meta-analysis. Am J Obstet Gynecol 188 (1): 220–7

    Article  PubMed  Google Scholar 

  • Jauniaux E, Holmes A et al. (2001) Rapid and radical amniodrainage in the treatment of severe twin-twin transfusion syndrome. Prenat Diagn 21 (6): 471–476

    Article  CAS  PubMed  Google Scholar 

  • Kahn B, Lumey LH et al. (2003) Prospective risk of fetal death in singleton, twin, and triplet gestations: implications for practice. Obstet Gynecol 102 (4): 685–692

    Article  PubMed  Google Scholar 

  • Kalish RB, Gupta M et al. (2004) Clinical significance of first trimester crown-rump length disparity in dichorionic twin gestations. Am J Obstet Gynecol 191 (4): 1437–40

    Article  PubMed  Google Scholar 

  • Kiely JL (1990) The epidemiology of perinatal mortality in multiple births. Bull N Y Acad Med 66 (6): 618–637

    CAS  PubMed Central  PubMed  Google Scholar 

  • Liu S, Benirschke K et al. (1992) Intrauterine death in multiple gestation. Acta Genet Med Gemellol (Roma) 41 (1): 5–26

    CAS  Google Scholar 

  • Luke B, Minogue J et al. (1993) The ideal twin pregnancy: patterns of weight gain, discordancy, and length of gestation. Am J Obstet Gynecol 169 (3): 588–597

    Article  CAS  PubMed  Google Scholar 

  • Machin G (2009) Non-identical monozygotic twins, intermediate twin types, zygosity testing, and the non-random nature of monozygotic twinning: a review. Am J Med Genet C Semin Med Genet 151C (2): 110–127

    Article  PubMed  Google Scholar 

  • Middeldorp JM, Lopriore E et al. (2007) Twin-to-twin transfusion syndrome after 26 weeks of gestation: is there a role for fetoscopic laser surgery? Br J Obstet Gynaecol 114 (6): 694–698

    Article  CAS  Google Scholar 

  • Minakami H, Sato I (1996) Reestimating date of delivery in multifetal pregnancies. JAMA 275 (18): 1432–1434

    Article  CAS  PubMed  Google Scholar 

  • Moore TR, Gale S et al. (1990) Perinatal outcome of forty-nine pregnancies complicated by acardiac twinning. Am J Obstet Gynecol 163 (3): 907–912

    Article  CAS  PubMed  Google Scholar 

  • Myles TD, Espinoza R et al. (1997) Preterm premature rupture of membranes: comparison between twin and singleton gestations. J Matern Fetal Med 6 (3): 159–163

    CAS  PubMed  Google Scholar 

  • O’Donoghue K, Rutherford MA et al. (2009) Transfusional fetal complications after single intrauterine death in monochorionic multiple pregnancy are reduced but not prevented by vascular occlusion. Br J Obstet Gynaecol 116 (6): 804–812

    Article  Google Scholar 

  • Ong SS, Zamora J et al. (2006) Prognosis for the co-twin following single-twin death: a systematic review. Br J Obstet Gynaecol 113 (9): 992–998

    Article  CAS  Google Scholar 

  • Ozturk O, Templeton A (2002) In-vitro fertilisation and risk of multiple pregnancy. Lancet 359 (9302): 232

    Article  PubMed  Google Scholar 

  • Pandian Z, Bhattacharya S et al. (2009) Number of embryos for transfer following in-vitro fertilisation or intra-cytoplasmic sperm injection. Cochrane Database Syst Rev 2: CD003416

    Google Scholar 

  • Pasquini L, Wimalasundera RC et al. (2006) High perinatal survival in monoamniotic twins managed by prophylactic sulindac, intensive ultrasound surveillance, and Cesarean delivery at 32 weeks’ gestation. Ultrasound Obstet Gynecol 28 (5): 681–687

    Article  CAS  PubMed  Google Scholar 

  • Petersen BL, Broholm H et al. (2001) Acardiac twin with preserved brain. Fetal Diagn Ther 16 (4): 231–233

    Article  CAS  PubMed  Google Scholar 

  • Pretorius DH, Leopold GR et al. (1988) Acardiac twin. Report of Doppler sonography. J Ultrasound Med 7 (7): 413–416

    CAS  PubMed  Google Scholar 

  • Quintero R, Munoz H et al. (1995) [Fetal endoscopic surgery in a case of twin pregnancy complicated by reversed arterial perfusion sequence (TRAP sequence)]. Rev Chil Obstet Ginecol 60 (2): 112–6; discussion 116–117

    Google Scholar 

  • Quintero RA, Morales WJ et al. (1999) Staging of twin-twin transfusion syndrome. J Perinatol 19(8 Pt 1): 550–555

    Article  CAS  PubMed  Google Scholar 

  • Rodis JF, McIlveen PF et al. (1997) Monoamniotic twins: improved perinatal survival with accurate prenatal diagnosis and antenatal fetal surveillance. Am J Obstet Gynecol 177 (5): 1046–1049

    Article  CAS  PubMed  Google Scholar 

  • Rossi AC, D’Addario V (2009) Umbilical cord occlusion for selective feticide in complicated monochorionic twins: a systematic review of literature. Am J Obstet Gynecol 200 (2): 123–129

    Article  PubMed  Google Scholar 

  • Sairam S, Costeloe K et al. (2002) Prospective risk of stillbirth in multiple- gestation pregnancies: a population-based analysis. Obstet Gynecol 100 (4): 638–641

    Article  PubMed  Google Scholar 

  • Salomon LJ, Cavicchioni O et al. (2005) Growth discrepancy in twins in the first trimester of pregnancy. Ultrasound Obstet Gynecol 26 (5): 512–516

    Article  CAS  PubMed  Google Scholar 

  • Savvidou MD, Karanastasi E et al. (2001) Twin chorionicity and preeclampsia. Ultrasound Obstet Gynecol 18 (3): 228–231

    Article  CAS  PubMed  Google Scholar 

  • Sebire NJ, D’Ercole C et al. (1998) Intertwin disparity in fetal size in monochorionic and dichorionic pregnancies. Obstet Gynecol 91 (1): 82–5

    Article  CAS  PubMed  Google Scholar 

  • Sebire NJ, Snijders RJ et al. (1996) Screening for trisomy 21 in twin pregnancies by maternal age and fetal nuchal translucency thickness at 10–14 weeks of gestation. Br J Obstet Gynaecol 103 (10): 999–1003

    Article  CAS  PubMed  Google Scholar 

  • Sebire NJ, Snijders RJ et al. (1997) The hidden mortality of monochorionic twin pregnancies. Br J Obstet Gynaecol 104 (10): 1203–1207

    Article  CAS  PubMed  Google Scholar 

  • Sebire NJ, Souka A et al. (2000) First trimester diagnosis of monoamniotic twin pregnancies. Ultrasound Obstet Gynecol 16 (3): 223–5

    Article  CAS  PubMed  Google Scholar 

  • Seif MM, Edi-Osagie EC et al. (2006) Assisted hatching on assisted conception (IVF & ICSI) Cochrane Database Syst Rev 1: CD001894

    Google Scholar 

  • Senat MV, Deprest J et al. (2004) Endoscopic laser surgery versus serial amnioreduction for severe twin-to-twin transfusion syndrome. N Engl J Med 351 (2): 136–144

    Article  CAS  PubMed  Google Scholar 

  • Senat MV, Loizeau S et al. (2003) The value of middle cerebral artery peak systolic velocity in the diagnosis of fetal anemia after intrauterine death of one monochorionic twin. Am J Obstet Gynecol 189 (5): 1320–1324

    Article  CAS  PubMed  Google Scholar 

  • Sepulveda W, Bower S et al. (1995) Ablation of acardiac twin by alcohol injection into the intra-abdominal umbilical artery. Obstet Gynecol 86(4 Pt 2): 680–681

    Article  CAS  PubMed  Google Scholar 

  • Sepulveda WH, Quiroz VH et al. (1993) Prenatal ultrasonographic diagnosis of acardiac twin. J Perinat Med 21 (3): 241–6

    Article  CAS  PubMed  Google Scholar 

  • Sherer DM (2001) Adverse perinatal outcome of twin pregnancies according to chorionicity: review of the literature. Am J Perinatol 18 (1): 23–37

    Article  CAS  PubMed  Google Scholar 

  • Simoes T, Amaral N et al. (2006) Prospective risk of intrauterine death of monochorionic-diamniotic twins. Am J Obstet Gynecol 195 (1): 134–139

    Article  PubMed  Google Scholar 

  • Singer E, Pilpel S et al. (2007) Accuracy of fetal fibronectin to predict preterm birth in twin gestations with symptoms of labor. Obstet Gynecol 109 (5): 1083–1087

    Article  CAS  PubMed  Google Scholar 

  • Sogaard K, Skibsted L et al. (1999) Acardiac twins: pathophysiology, diagnosis, outcome and treatment. Six cases and review of the literature. Fetal Diagn Ther 14 (1): 53–59

    Article  CAS  PubMed  Google Scholar 

  • Spencer K (2000) Screening for trisomy 21 in twin pregnancies in the first trimester using free beta-hCG and PAPP-A, combined with fetal nuchal translucency thickness. Prenat Diagn 20 (2): 91–5

    Article  CAS  PubMed  Google Scholar 

  • Tita AT, Rouse DJ (2009) Progesterone for preterm birth prevention: an evolving intervention. Am J Obstet Gynecol 200 (3): 219–224

    Article  CAS  PubMed  Google Scholar 

  • To MS, Fonseca EB et al. (2006) Maternal characteristics and cervical length in the prediction of spontaneous early preterm delivery in twins. Am J Obstet Gynecol 194 (5): 1360–1365

    Article  PubMed  Google Scholar 

  • Tong S, Caddy D et al. (1997) Use of dizygotic to monozygotic twinning ratio as a measure of fertility. Lancet 349 (9055): 843–845

    Article  CAS  PubMed  Google Scholar 

  • Tsoi E, Akmal S et al. (2003) Ultrasound assessment of cervical length in threatened preterm labor. Ultrasound Obstet Gynecol 21 (6): 552–555

    Article  CAS  PubMed  Google Scholar 

  • Udom-Rice I, Inglis SR et al. (2000) Optimal gestational age for twin delivery. J Perinatol 20 (4): 231–234

    Article  CAS  PubMed  Google Scholar 

  • Van Allen MI, Smith DW et al. (1983) Twin reversed arterial perfusion (TRAP) sequence: a study of 14 twin pregnancies with acardius. Semin Perinatol 7 (4): 285–293

    CAS  PubMed  Google Scholar 

  • Vandecruys H, Avgidou K et al. (2006) Dilemmas in the management of twins discordant for anencephaly diagnosed at 11 + 0 to 13 + 6 weeks of gestation. Ultrasound Obstet Gynecol 28 (5): 653–658

    Article  CAS  PubMed  Google Scholar 

  • Weisz B, Pandya P et al. (2005) Scanning for chorionicity: comparison between sonographers and perinatologists. Prenat Diagn 25 (9): 835–838

    Article  PubMed  Google Scholar 

  • Wennerholm UB, Holm B et al. (1997) Fetal fibronectin, endotoxin, bacterial vaginosis and cervical length as predictors of preterm birth and neonatal morbidity in twin pregnancies. Br J Obstet Gynaecol 104 (12): 1398–404

    Article  CAS  PubMed  Google Scholar 

  • Wenstrom KD, Syrop CH et al. (1993) Increased risk of monochorionic twinning associated with assisted reproduction. Fertil Steril 60 (3): 510–514

    CAS  PubMed  Google Scholar 

  • Yamamoto M, Ville Y (2006) Recent findings on laser treatment of twin-to-twin transfusion syndrome. Curr Opin Obstet Gynecol 18 (2): 87–92

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Universitätsklinik für Frauenheilkunde Abt. für Geburtshilfe und feto-maternale Medizin, AKH, Währinger Gürtel 18–20, Wien, 1090, Österreich

    Univ.-Doz. Dr. med. E. Krampl-Bettelheim

Authors
  1. Univ.-Doz. Dr. med. E. Krampl-Bettelheim
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Univ.Klinikum Bern Frauenklinik, Bern, Schweiz

    Henning Schneider

  2. Klinische Abt. Geburtshilfe und Feto-maternale Medizin, Medizinische Universität Wien Universitätsklinik für Frauenheilkunde, Wien, Österreich

    Peter-Wolf Husslein

  3. Frauenklinik und Poliklinik Abt. Perinatalmedizin, TU München Klinikum Rechts der Isar, München, Deutschland

    Karl Theo Maria Schneider

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Krampl-Bettelheim, E. (2011). Mehrlinge. In: Schneider, H., Husslein, PW., Schneider, K. (eds) Die Geburtshilfe. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12974-2_42

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-12974-2_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-40181-7

  • Online ISBN: 978-3-642-12974-2

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation