Zusammenfassung
Es ist vielleicht gerechtfertigt zu sagen, dass die Befunde der funktionellen Bildgebung der letzten 10 Jahre bei Schlaganfallpatienten viele Gedanken der Rehabilitation auf eine neue neurobiologische Basis gestellt haben und dadurch der Rehabilitation Schwung, Interesse und neuen Enthusiasmus gebracht haben und auch Wege aufgezeigt haben, wie rehabilitative Techniken auf neurobiologischer Basis evaluiert werden könnten. Man versteht besser, was im Gehirn eines Schlaganfallpatienten vorgeht. Man »sieht« den ipsilateralen Kortex aufblitzen, wenn Mitbewegungen der gesunden Seite bei der Visite zu beobachten sind und kann vielleicht die Rückbildung der Diaschisis vermuten, wenn sich die Sprache innerhalb der ersten Woche plötzlich von einem auf den anderen Tag deutlich bessert. Gerade erst scheint die Zeit zu beginnen, in der Messungen am Patienten eine konkrete Anpassung der Behandlung bringen.
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Literatur
Basso A, Gardelli M, Grassi MP, Mariotti M. The role of the right hemisphere in recovery from aphasia: two case studies. Cortex 1989;25:555–566.
Benecke R, Meyer BU, Freund HJ. Reorganization of descending motor pathways in patients after hemispherectomy and severe hemispheric lesions demonstrated by magnetic brain stimulation. Exp Brain Res 1991;83:419–426.
Binder J. Functional magnetic resonance imaging. Language mapping. Neurosurg Clin N Am 1997;8:383–92.
Binkofski F, Seitz R, Arnold S, Claben J, Hackländer T, Tyercha D et al. Motor recovery after hemiparetic stroke: relation to pyramidal tract damage and thalamic hypometabolism. J Cereb Blood Flow Metab 1995;15, Suppl. I:S689.
Binkofski F, Seitz RJ, Arnold S, Classen J, Benecke R, Freund HJ. Thalamic metbolism and corticospinal tract integrity determine motor recovery in stroke. Ann Neurol 1996;39:460–470.
Birbaumer N, Lutzenberger W, Montoya P, Larbig W, Unertl K, Topfner S et al. Effects of regional anesthesia on phantom limb pain are mirrored in changes in cortical reorganization. J Neurosci 1997;17:5503–8.
Boroojerdi B, Diefenbach K, Ferbert A. Transcallosal inhibition in cortical and subcortical cerebral vascular lesions. J Neurol Sci 1996;144:160–170.
Büchel C. Functional neuroimaging studies of Braille reading: cross- modal reorganization and its implications. Brain 1998;121:1193–4.
Bülau P, Smetanay M, Weiller C, Solymosi L. Wallersche Degeneration des Pyramidenbahntraktes nach Schlaganfall. Neurologie & Rehabilitation 1995;1:44–49.
Bütefisch C, Netz J, Wessling M, Seitz R, Hömberg V. Remote changes in cortical excitability after stroke. Brain 2003;126:470–481.
Calauti C, Leroy F, Guincestre JY, Marie RM, Baron JC. Sequential activation brain mapping after subcortical stroke. NeuroReport 2001;12:3883–3886.
Cao Y, D'Olhaberriague L, Vikingstad EM, Levine SR, Welch KMA. Pilot study of functional MRI to assess cerebral activation of motor function after poststroke hemiparesis. Stroke 1998;29:112–122.
Cappa SF, Vallar G. The role of the left and the right hemishere in recovery from aphasia. Aphasiology 1992;6.
Caramia MD, Iani C, Bernardi G. Cerebral plasticity after stroke as revealed by ipsilateral response to magnetic stimulation. NeuroReport 1996;7:1756–1760.
Catano A, Houa M, Caroyer JM, Ducarne H, Noel P. Magnetic trancranial stimulation in stroke: early excitation thresholds and functional prognosis. Electroenceph Clin Neurophysiol 1996;101:233–239.
Chollet F, DiPiero V, Wise RJS, Brooks DJ, Dolan RJ, Frackowiak RSJ. The functional anatomy of motor recovery after stroke in humans: a study with positron emission tomography. Ann Neurol 1991;29:63–71.
Classen J, Liepert J, Wise SP, Hallett M, Cohen LG. Rapid plasticity of human cortical movement representation induced by practice. J Neurophysiol 1998;79:1117–1123.
Darian-Smith I, Burman K, Darian-Smith C. Parallel pathways mediating manual dexterity in the macaque. Exp Brain Res 1999; present volume.
Dettmers C, Stephan KM, Lemon RN, Frackowiak RSJ. Reorganization of the executive motor system after stroke. Cerebrovasc Dis 1997;7:187–200.
Dettmers C, Liepert J, Adler T, Rzanny R, Rijntjes M, van Schayck R et al. Abnormal motor cortex organization contralateral to early upper limb amputation in humans. Neurosci Lett 1999;263:41–44.
DiPiero V, Chollet F, MacCarthy P, Lenzi GL, Frackowiak RSJ. Motor recovery after acute ischaemic stroke: a metabolic study. J Neurol Neurosurg Psychiatry 1992;55:960–966.
Dum RP, Strick PL. The origin of corticospinal projections from the premotor areas in the frontal lobe. J Neurosci 1991;11:667–689.
Elbert T, Pantev C, Wienbruch C, Rockstroh B, Taub E. Increased cortical representation of the fingers of the left hand in string players. Science 1995;270:305–307.
Feeney DM, Baron JC. Diaschisis. Stroke 1986;17:817–830.
Feydy A, Carlier R, Roby-Brami A, Bussel B, Cazalis F, Pierot L et al. Longitudinal study of motor recovery after stroke: recruitment and focusing of brain activation. Stroke 2002;33:1610–1617.
Fink GR, Frackowiak RS, Pietrzyk U, Passingham RE. Multiple nonprimary motor areas in the human cortex. J Neurophysiol 1997;77:2164–74.
Fisher CM. Concerning the mechanism of recovery in stroke hemiplegia. Can J Neurol Sci 1992;19:57–63.
Floel A, Breitenstein C, Knecht S. The role of the left frontal lobe in action naming. rTMS evidence. Neurology 2003;60:1052.
Flor H, Elbert T, Knecht S, Wienbruch C, Pantev C, Birbaumer N et al. Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature 1995;375:482–4.
Fries W, Danek A, Scheidtmann K, Hamburger C. Motor recovery following capsular stroke. Brain 1993;116:369–382.
Frost SB, Barbay S, Friel KM, Plautz EJ, Nudo RJ. Reorganization of remote cortical regions after ischemic brain injury: a potential source for stroke recovery. J Neurophysiol 2003;89:3205–3214.
Garcia JH, Lassen NA, Weiller C, Sperling B, Nakagawara J. Incomplete brain infarction: Clinical and experimental evidence demonstrating its existence (Editorial). Stroke 1995;26.
Goldstein L. Common drugs may influence motor recovery after stroke. Neurology 1995;45:865–870.
Guerreiro M, Castro-Caldas A, Martins I. Aphasia Following Right Hemisphere Lesion in a Woman with Left Hemisphere Injury in Childhood. Brain Lang 1995;49:280–288.
Hamzei F, Liepert J, Dettmers C, Weiller C, Rijntjes M. Two different reorganization patterns after rehabilitative therapy: an exploratory study with fMRI and TMS. Neuroimage 2006;31:710–20.
Hamzei F, Dettmers C, Rijntjes M, Weiller C. The effect of cortico-spinal tract damage on primary sensorimotor cortex activation after rehabilitation therapy. Exp Brain Res 2008;190:329–36.
Heald A, Bates D, Cartlidge NEF, French JM, Miller S. Longitudinal study of central motor conduction time following stroke. 2. Central motor conduction measured within 72 hours after stroke as a predictor of cuntional outcome at 12 months. Brain 1993;116:1371–1385.
Heiss WD, Kessler J, Thiel A, Ghaemi M, Karbe H. Differential Capacity of Left and Right Hemispheric Areas for Compensation of poststroke aphasia. Ann Neurol 1999;45:430–438.
Heiss WD, Pawlik G, Dietz E. Hypometabolism and functional recruitment as related to prognosis in poststroke aphasia. J Cereb Blood Flow Metab 1991;11:660.
Hennig J, Speck O, Koch MA, Weiller C. Functional magnetic resonance imaging: a review of methodological aspects and clinical applications. J Magn Reson Imaging 2003;18:1–15.
Johansen-Berg H, Rushworth M, Bogdanovic M, Kischka U, Wimalaratna S, Matthews PM. The role of ipsilateral premotor cortex in hand movement after stroke. PNAS 2002;99:4518–14523.
Kaas JH. Plasticity of sensory and motor maps in adult mammals. Ann Rev Neurosci 1991;14:137–167.
Kaas J, Florence S, Jain N. Reorganization of sensory systems of primates after injury. Neuroscientist 1997;3:123–130.
Karbe HHSPWH. Regional metabolic correlates of token test results in cortical and subcortical left hemispheric infartion. Neurology 1989;39:1083–1088.
Kinsbourne M. The minor hemisphere as a source of aphasic speech. Trans Amer Neurol Assoc 1971;96:141–145.
Lemon RN. Stroke recovery. Current Opinion in Neurobiology 1993;3:463–465.
Lichtheim L. On aphasia. Brain 1885;7:433–484.
Liepert J, Tegenthoff M, Malin JP. Changes of cortical motor area size during immobilization. Electroencephalogr Clin Neurophysiol 1995;97:382–386.
Liepert J, Miltner WH, Bauder H, Sommer M, Dettmers C, Taub E et al. Motor cortex plasticity during constraint-induced movement therapy in stroke patients. Neurosci Lett 1998;250:5–8.
Liepert J, Terborg C, Weiller C. Cerebral plasticity induced by synchronous thumb and foot movements. Exp Brain Res 1999;125:435–439.
Liepert J, Bauder H, Wolfgang HR, Miltner WH, Taub E, Weiller C. Treatment- induced cortical reorganization after stroke in humans. Stroke 2000;31:1210–6.
Liepert J, Schardt S, Weiller C. Orally administered atropine enhances motor cortex excitability: a transcranial magnetic stimulation study in human subjects. Neuro Sci Let 2001;300:149–152.
Liu Y, Rouiller EM. Mechanisms of recovery of dexterity following unilateral lesion of the sensorimotor cortex in adult monkeys. Exp Brain Res 1999; present volume.
Loubinoux I, Boulanouar K, Ranjeva JP, Carel C, Berry I, Rascol O et al. Cerebral functional magnetic resonance imaging activation modulated by a single dose of the monoamine neurotransmission enhancers fluoxetine and fenozolone during hand sensormotor tasks. J Cereb Blood Flow Metab 1999;19:1365–1375.
Manganotti P, Patuzzo S, Cortese F, Palermo A, Smania N, Fiaschi A. Motor disinhibition in affected and unaffected hemisphere in the early period of recovery after stroke. Clin Neurophysiol 2002;113:939–943.
Marie P. Travaux et memoires. Paris: Masson et Cie; 1926.
Marshall RS, Perera GM, Lazar RM, Krakauer JW, Constantine RC, DeLa-Paz RL. Evolution of cortical activation during recovery from corticospinal tract infarction. Stroke 2000;31:656–661.
Merzenich MM, Nelson RJ, Stryker MP, Cynader MS, Shoppmann A, Zook JM. Somatosensory cortical map changes following digital amputation in adult monkey. J Comp Neurol 1982;224:591–605.
Mesulam MM. A cortical network for directed attention and unilateral neglect. Ann Neurol 1981;10:309–25.
Mesulam MM. Large-scale neurocognitive networks and distributed processing for attention, language, and memory. Ann Neurol 1990;28:597–613.
Metter EJ, Wasterlain CG, Kuhl DE, Hanson WR, Phelps ME. 18FDG-positron emission computed tomography in a study of aphasia. Annals of Neurology 1981;10:173–183.
Mimura M, Kato M, Kata M, Sano Y, Kojima T, Naeser M et al. Prospective and retrospective studies of recovery in aphasia. Brain 1998;121:2083–2094.
Musso M, Weiller C, Kiebel S, Müller S, Bülau P, Rijntjes M. Training induced plasticity in aphasia. Brain 1999;122:1781–1790.
Nagata K, Shinohara T, Yokoyama E, Satoh Y, Watahiki Y, Sato M et al. Possible vicarious functioning of the unaffected hemisphere for recovery from unilateral cerebral infarction. J Cereb Blood Flow Metab 1995;15:695.
Nakagawara J, Sperling B, Lassen NA. Incomplete brain infarction of reperfused cortex may be quantitated with iomazenil. Stroke 1997;28:124–32.
Nelles G, Jentzen W, Jueptner M, Muller SHCD. Arm training induced brain plasticity in stroke studied with serial positron emission tomography. NeuroImage 2001;13:1146–1154.
Nelles G, Spiekermann G, Jüptner M, Leonhardt G, Müller S, Gerhard H et al. Evolution of functional reorganisation in hemiplegic stroke: a serial positro emission tomographic activation study. Ann Neurol 1999;46:901–909.
Netz J, Lammers T, Hömberg V. Reorganization of motor output in the non-affected hemisphere after stroke. Brain 1997;120:1579–1587.
Niehaus L, Bajbouj M, Meyer BU. Impact of interhemispheric inhibition on excitability of the non-lesioned motor cortex after acute stroke. Cin Neurophysiol 2003;56(Suppl):181–186.
Nudo RJ. Remodeling of cortical motor representations after stroke: implications for recovery from brain damage [news]. Mol Psychiatry 1997;2:188–91.
Ohyama M, Senda M, Terashi A, Kitamura S, Toyama H, Ishii K et al. A follow up PET activation study in aphasia due to cerebral infarction evaluates functional reorganization. J Cereb Blood Flow Metab 1995;15:697.
Palmer E, Ashby P, Hajek VE. Ipsilateral fast corticospinal pathways do not account for recovery in stroke. Ann Neurol 1992;32:519–525.
Pantano P, Formisano R, Ricci M, Di Piero V, Sabatini U, Barbanti P et al. Prolonged muscular flacidity after stroke: morphological and functional brain alterations. J Cereb Blood Flow Metab 1995;15:688.
Papanicolaou AC, Moore BD, Deutsch G, Levin HS, Eisenberg HM. Evidence for right-hemisphere involvement in recovery from aphasia. Arch Neurol 1988;45:1025–1029.
Pariente J, Loubinoux I, Carel C, Albucher JF, Leger A, Manelfe C et al. Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke. Ann Neurol 2001;50:718–729.
Price CJ, Wise RJ, Watson JD, Patterson K, Howard D, Frackowiak RS. Brain activity during reading. The effects of exposure duration and task. Brain 1994;117:1255–69.
Price C, Warburton E, Swinburn K, Wise R, Frackowiak R. Monitoring the recovery of aphasia using positron emission tomography. J Cereb Blood Flow Metab 1995;15:696.
Reinecke S, Lutzenburg M, Hagemann G, Bruehl C, Neumann-Haefelin T, Witte OW. Electrophysiological transcortical diaschisis after middle cerebral artery occlusion (MCAO) in rats. Neurosci Let 1999;261:85–88.
Rijntjes M. Mitbewegungen der Gegenseite nach Schlaganfall. Neurologie & Rehabilitation 1999;5:15–18.
Rijntjes M. Two types of reorganization in recovery from chronic stroke, depending in the involvement of primary motor cortex. Neuroimage 2003;19:53.
Rijntjes M. Mechanisms of recovery in stroke patients with hemiparesis or aphasia: new insights, old questions and the meaning of therapies. Curr Opin Neurol 2006;19:76–83.
Rijntjes M, Tegenthoff M, Liepert J, Leonhardt G, Kotterba S, Muller S et al. Cortical reorganization in patients with facial palsy. Ann Neurol 1997;41:621–630.
Rijntjes M, Dettmers C, Buchel C, Kiebel S, Frackowiak RS, Weiller C. A blueprint for movement: functional and anatomical representations in the human motor system. J Neurosci 1999;19:8043–8.
Rijntjes M, Weiller C. Recovery of motor and language abilities after stroke: the contribution of functional imaging. Progress Neurobiology 2002;66:109–122.
Rouiller EM, Yu XH, Moret V, Tempini A, Wiesendanger M, Liang F. Dexterity in adult monkeys following early lesion of the motor cortical hand area: the role of cortex adjacent to the lesion. Eur J Neurosci 1998;10:729–740.
Saur D, Lange R, Baumgaertner A, Schraknepper V, Willmes K, Rijntjes M et al. Dynamics of language reorganization after stroke. Brain 2006;129:1371–84.
Seitz R, Schlaug G, Kleinschmidt A, Knorr U, Nebeling B, Wirrwar A et al. Remote depressions of cerebral metabolism in hemiparetic stroke: Topography and relation to motor and somatosensory functions. Human Brain Mapping 1994;1:81–100.
Seitz RJ, Höflich P, Binkofski F, Tellmann L, Herzog H, Freund HJ. Role of the premotor cortex in recovery from middle cerebral artery infarction. Arch Neurol 1998;55:1081–1088.
Shimizu T, Hosaki A, Hino T, Sato M, Komori T, Hirai S et al. Motor cortical disinhibition in the unaffected hemisphere after unilateral cortical stroke. Brain 2002;125:1896–1907.
Siebner HR, Willoch F, Peller M, Auer C, Boecker H, Conrad B et al. Imaging brain activation induced by long trains of repetitive transcranial magnetic stimulation [In Process Citation]. Neuroreport 1998;9:943–8.
Small SL. Pharmacotherapy of aphasia: a critical review. Stroke 1994;25:1282–1289.
Stephan K, Fink G, Passingham R, Silbersweig D, Ceballos-Baumann A, Frith C et al. Motor Imagery and performance of hand-movements. J Neurol 1994;241:suppl 1.
Taub E, Crago JE, Burgio LD, Groomes TE, Cook EWr, DeLuca SC et al. An operant approach to rehabilitation medicine: overcoming learned nonuse by shaping. J Exp Anal Behav 1994;61:281–293.
Timmerhuis TP, Hagemann G, Oosterloo SJ, Rozeboom AR. The prognostic value of cortical magnetic stimulation in acute middle cerebral artery infarction compared to other parameters. Clin Neurol Neurosurg 1996;98:231–236.
Thomalla G, Glauche V, Restemeyer C, Hamzei F, Rijntjes M, Liepert J et al. Pyramidenbahnschädigung, Reorganisation und Wiederherstellung motorischer FUnktion nach Hirninfarkt, untersucht mit DTI und fMRT. Aktuelle Neurologie 2003;30:88.
Trompetto C, Assini A, Buccolieri A, Marchese R, Abbruzzese G. Motor recovery following stroke: a transcranial magnetic stimulation study. Clin Neurophysiol 2000;111:1860–1867.
Turton A, Wroe SJ, Trepte N, Fraser C, Lemon RN. Contralateral and ispilateral EMG responses to trancranial magnetic stimulation during recovery of arm and hand function after stroke. Electroenceph Clin Neurophysiol 1996;101:316–328.
Ungerleider L, Doyon J, Karni A. Imaging brain plasticity during motor skill learning. Neurobiol Learn Mem 2002;78:553–564.
Warburton E, Price C, Swinburn K, Wise RJS. Mechanisms of recovery from aphasia: evidence from positron emission tomography studies. J Neurol Neurosurg Psychiatry 1999;66:155–161.
Ward NS, Brown MM, Thompson AJ, Frackowiak RS. Neural correlates of motor recovery after stroke: a longitudinal fMRI study. Brain 2003;126:2476–96.
Watson JDG, Myers R, Frackowiak RSJ, Hajnal JV, Woods RP, Mazziotta JC et al. Area V5 of the human brain: Evidence from a combined Study using Positron Emission Tomography and Magnetic Resonance Imaging. Cereb Cortex 1993;3:79–94.
Weder B, Seitz RJ. Deficient cerebral activation pattern in stroke recovery. NeuroReport 1994;5:457–460.
Weiller C. Brain representation of active and passive movements. NeuroImage 1996;4:105–110.
Weiller C, Chollet F, Friston KJ, Wise RJ, Frackowiak RS. Functional reorganization of the brain in recovery from striatocapsular infarction in man. Ann Neurol 1992;31:463–72.
Weiller C, Ramsay SC, Wise RJS, Friston KJ, Frackowiak RSJ. Individual patterns of functional reorganization in the human cerebral cortex after capsular infarction. Ann Neurol 1993;33:181–189.
Weiller C, Isensee C, Rijntjes M, Huber W, Muller S, Bier D et al. Recovery from Wernicke's aphasia: a positron emission tomographic study. Ann Neurol 1995;37:723–32.
Weiller C, Rijntjes M. Learning, plasticity, and recovery in the central nervous system. Exp Brain Res 1999;128:134–8.
Winhuisen L, Thiel A, Schumacher B, Kessler J, Rudolf J, Haupt WF et al. Role of the contralateral inferior frontal gyrus in recovery of language function in poststroke aphasia: a combined repetitive transcranial magnetic stimulation and positron emission tomography study. Stroke 2005;36:1759–63.
Witte OW, Buchkremer-Ratzmann I, Schiene K, Neumann-Haefelin T, Hagemann G, Kraemer M et al. Lesion-induced network plasticity in remote brain areas [letter; comment]. Trends Neurosci 1997;20:348–9.
Zaidel E. Language in the right hemisphere. In: Benson DF, Zaidel E (eds). The dual brain. New York: Guilford; 1985. S. 205–231.
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Rijntjes, M., Weiller, C., Liepert, J. (2010). Funktionelle Bildgebung in der Neurorehabilitation. In: NeuroRehabilitation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12915-5_6
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