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Extracellular Nucleic Acids pp 1–14Cite as

Extracellular DNA as Matrix Component in Microbial Biofilms

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Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 25))

Abstract

Bacteria in nature primarily live in surface-associated communities commonly known as biofilms. Because bacteria in biofilms, in many cases, display tolerance to host immune systems, antibiotics, and biocides, they are often difficult or impossible to eradicate. Biofilm formation, therefore, leads to various persistent infections in humans and animals, and to a variety of complications in industry, where solid–water interfaces occur. Knowledge about the molecular mechanisms involved in biofilm formation is necessary for creating strategies to control biofilms. Recent studies have shown that extracellular DNA is an important component of the extracellular matrix of microbial biofilms. The present chapter is focussed on extracellular DNA as matrix component in biofilms formed by Pseudomonas aeruginosa as an example from the Gram-negative bacteria, and Streptococcus and Staphylococcus as examples from the Gram-positive bacteria. Besides the role of extracellular DNA in biofilm formation, the mechanisms involved in DNA release from P. aeruginosa, Streptococcus, and Staphylococcus are addressed.

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Authors and Affiliations

  1. Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark

    Wen-Chi Chiang & Tim Tolker-Nielsen

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  1. Wen-Chi Chiang
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Correspondence to Tim Tolker-Nielsen .

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Editors and Affiliations

  1. , Dept. of Environmental and Life Sciences, Toyohashi University of Technology, Toyohashi-city, 441-8580, Japan

    Yo Kikuchi

  2. Fundamental Medicine, Institute of Chemical Biology and, Lavrentjeva Prospect 8, Novosibirsk, 630090, Russian Federation

    Elena Y. Rykova

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Chiang, WC., Tolker-Nielsen, T. (2010). Extracellular DNA as Matrix Component in Microbial Biofilms. In: Kikuchi, Y., Rykova, E. (eds) Extracellular Nucleic Acids. Nucleic Acids and Molecular Biology, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12617-8_1

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